ATP6V0A2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006955Biological processimmune response
GO_0036295Biological processcellular response to increased oxygen levels
GO_0006879Biological processintracellular iron ion homeostasis
GO_0007035Biological processvacuolar acidification
GO_0061795Biological processGolgi lumen acidification
GO_0016241Biological processregulation of macroautophagy
GO_1902600Biological processproton transmembrane transport
GO_0001669Cellular componentacrosomal vesicle
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_1902495Cellular componenttransmembrane transporter complex
GO_0033176Cellular componentproton-transporting V-type ATPase complex
GO_0005925Cellular componentfocal adhesion
GO_0000139Cellular componentGolgi membrane
GO_0030670Cellular componentphagocytic vesicle membrane
GO_0000220Cellular componentvacuolar proton-transporting V-type ATPase, V0 domain
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0010008Cellular componentendosome membrane
GO_0016471Cellular componentvacuolar proton-transporting V-type ATPase complex
GO_0005765Cellular componentlysosomal membrane
GO_0046961Molecular functionproton-transporting ATPase activity, rotational mechanism
GO_0051117Molecular functionATPase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameATP6V0A2
Protein nameV-type proton ATPase subunit a
V-type proton ATPase 116 kDa subunit a 2 (V-ATPase 116 kDa subunit a 2) (Lysosomal H(+)-transporting ATPase V0 subunit a 2) (TJ6) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2)
SynonymshCG_1786229
DescriptionFUNCTION: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Essential component of the endosomal pH-sensing machinery . May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH . In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation . .

FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. .

FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. .

FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. .

FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. .

FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. .

FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. .

AccessionsENST00000544833.1
A0A6Q8PHG7
ENST00000675344.1
F5H847
ENST00000674794.1
ENST00000330342.8
A0A6Q8PFU6
F5H5F3
ENST00000504192.2
ENST00000534943.5
Q8TBM3
ENST00000613625.5
Q9Y487
F5GX48