PPIA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060352Biological processcell adhesion molecule production
GO_0006469Biological processnegative regulation of protein kinase activity
GO_0032148Biological processactivation of protein kinase B activity
GO_0035307Biological processpositive regulation of protein dephosphorylation
GO_0070527Biological processplatelet aggregation
GO_0030593Biological processneutrophil chemotaxis
GO_1902176Biological processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0030595Biological processleukocyte chemotaxis
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0042118Biological processendothelial cell activation
GO_0045069Biological processregulation of viral genome replication
GO_0045070Biological processpositive regulation of viral genome replication
GO_0030168Biological processplatelet activation
GO_0032873Biological processnegative regulation of stress-activated MAPK cascade
GO_0050714Biological processpositive regulation of protein secretion
GO_0006457Biological processprotein folding
GO_0001933Biological processnegative regulation of protein phosphorylation
GO_0030182Biological processneuron differentiation
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0034599Biological processcellular response to oxidative stress
GO_0034389Biological processlipid droplet organization
GO_0019076Biological processviral release from host cell
GO_0006915Biological processapoptotic process
GO_1903901Biological processnegative regulation of viral life cycle
GO_2001233Biological processregulation of apoptotic signaling pathway
GO_0061944Biological processnegative regulation of protein K48-linked ubiquitination
GO_0000413Biological processprotein peptidyl-prolyl isomerization
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0032991Cellular componentprotein-containing complex
GO_0005925Cellular componentfocal adhesion
GO_0034774Cellular componentsecretory granule lumen
GO_1904813Cellular componentficolin-1-rich granule lumen
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0031982Cellular componentvesicle
GO_0005634Cellular componentnucleus
GO_0003755Molecular functionpeptidyl-prolyl cis-trans isomerase activity
GO_1904399Molecular functionheparan sulfate binding
GO_0005178Molecular functionintegrin binding
GO_0051082Molecular functionunfolded protein binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_0046790Molecular functionvirion binding
GO_0016018Molecular functioncyclosporin A binding

IV. Literature review

[source]
Gene namePPIA
Protein namePeptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) [Cleaved into: Peptidyl-prolyl cis-trans isomerase A, N-terminally processed]
Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8)
Peptidylprolyl isomerase A
SynonymsCYPA
DescriptionFUNCTION: Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides . Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation . Activates endothelial cells (ECs) in a pro-inflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 . Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis . In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 . Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 . Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates . Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans . Inhibits replication of influenza A virus (IAV) . Inhibits ITCH/AIP4-mediated ubiquitination of matrix protein 1 (M1) of IAV by impairing the interaction of ITCH/AIP4 with M1, followed by the suppression of the nuclear export of M1, and finally reduction of the replication of IAV . .; FUNCTION: (Microbial infection) May act as a mediator between human SARS coronavirus nucleoprotein and BSG/CD147 in the process of invasion of host cells by the virus . .; FUNCTION: (Microbial infection) Stimulates RNA-binding ability of HCV NS5A in a peptidyl-prolyl cis-trans isomerase activity-dependent manner. .

FUNCTION: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. .

FUNCTION: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. .

FUNCTION: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. .

AccessionsENST00000677107.1 [P62937-2]
ENST00000678789.1 [P62937-2]
ENST00000415933.5
ENST00000676977.1
C9J5S7
A0A7P0S768
E5RIZ5
A0A7I2V5J5
ENST00000620047.5
ENST00000480603.1
ENST00000355968.10 [P62937-2]
ENST00000678805.1 [P62937-2]
ENST00000451562.5
P62937
ENST00000479021.1
ENST00000468812.6 [P62937-1]
ENST00000677022.1 [P62937-2]
A0A7I2V4V1
F8WE65
ENST00000489459.5 [P62937-2]