FLII report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051014Biological processactin filament severing
GO_0051016Biological processbarbed-end actin filament capping
GO_0030239Biological processmyofibril assembly
GO_0008154Biological processactin polymerization or depolymerization
GO_0005903Cellular componentbrush border
GO_0015629Cellular componentactin cytoskeleton
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005925Cellular componentfocal adhesion
GO_0034451Cellular componentcentriolar satellite
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005546Molecular functionphosphatidylinositol-4,5-bisphosphate binding
GO_0051015Molecular functionactin filament binding
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding

IV. Literature review

[source]
Gene nameFLII
Protein nameProtein flightless-1 homolog
FLII actin remodeling protein
FLII actin remodeling protein (Protein flightless-1 homolog)
SynonymsFLIL
DescriptionFUNCTION: May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development (By similarity). May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation. .

AccessionsA0A1W2PP30
ENST00000577485.1
Q13045
ENST00000577626.1
A0A1W2PR04
J3KS54
ENST00000639036.1
K7EP37
ENST00000327031.9 [Q13045-1]
A0A1W2PPD5
ENST00000639299.1
ENST00000581858.5
ENST00000639967.1
ENST00000640276.1
ENST00000638812.1 [Q13045-3]
ENST00000628188.1
K7EP27
J3KS39
ENST00000578558.5
A0A1W2PQI6
A0A1W2PS03
ENST00000545457.6 [Q13045-2]
ENST00000578101.5
ENST00000488932.5
ENST00000640595.1
J3QLR6
ENST00000638404.1 [Q13045-2]
K7EQZ7
ENST00000581401.1
ENST00000581349.5
ENST00000579294.5 [Q13045-3]
ENST00000638207.2 [Q13045-1]
ENST00000639646.1
J3QQU5
A0A1W2PNT9
ENST00000638982.1
ENST00000638637.1
ENST00000473425.2
A0A1W2PPN0
J3QQQ2
ENST00000638796.1
A0A1W2PSB1
J3KT47
ENST00000577398.6
ENST00000639125.1
ENST00000640412.1
K7EJJ7