ATAT1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ATAT1 at tissue level.

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_0007283Biological processspermatogenesis
GO_0044546Biological processNLRP3 inflammasome complex assembly
GO_0021542Biological processdentate gyrus development
GO_1900227Biological processpositive regulation of NLRP3 inflammasome complex assembly
GO_0048265Biological processresponse to pain
GO_0048666Biological processneuron development
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_0071929Biological processalpha-tubulin acetylation
GO_0045598Biological processregulation of fat cell differentiation
GO_0009612Biological processresponse to mechanical stimulus
GO_0070507Biological processregulation of microtubule cytoskeleton organization
GO_0005874Cellular componentmicrotubule
GO_0072686Cellular componentmitotic spindle
GO_0005794Cellular componentGolgi apparatus
GO_0097427Cellular componentmicrotubule bundle
GO_0005925Cellular componentfocal adhesion
GO_0005829Cellular componentcytosol
GO_0005905Cellular componentclathrin-coated pit
GO_0030424Cellular componentaxon
GO_0019799Molecular functiontubulin N-acetyltransferase activity
GO_0004468Molecular functionlysine N-acetyltransferase activity, acting on acetyl phosphate as donor
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameATAT1
Protein nameAlpha-tubulin N-acetyltransferase 1 (Alpha-TAT) (Alpha-TAT1) (TAT) (EC 2.3.1.108) (Acetyltransferase mec-17 homolog)
SynonymsNbla00487
MEC17
C6orf134
DescriptionFUNCTION: Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly. .

FUNCTION: Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly. .

FUNCTION: Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly. .

FUNCTION: Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly. .

AccessionsENST00000425448.2 [Q5SQI0-2]
B7Z4Q7
ENST00000424121.5 [Q5SQI0-6]
ENST00000449905.5 [Q5SQI0-7]
ENST00000450003.6 [Q5SQI0-4]
ENST00000383583.8 [Q5SQI0-4]
ENST00000411724.5 [Q5SQI0-5]
ENST00000423654.5 [Q5SQI0-5]
ENST00000330083.6 [Q5SQI0-2]
Q5SQI0
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ENST00000457334.2 [Q5SQI0-2]
ENST00000445973.5 [Q5SQI0-6]
B7Z5C8
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ENST00000432643.6 [Q5SQI0-2]
ENST00000445486.6 [Q5SQI0-1]
ENST00000416435.2 [Q5SQI0-2]
ENST00000428764.6 [Q5SQI0-4]
ENST00000454794.6 [Q5SQI0-1]
ENST00000448670.2 [Q5SQI0-2]
ENST00000423338.5 [Q5SQI0-7]
ENST00000418248.5 [Q5SQI0-5]
ENST00000376483.8 [Q5SQI0-5]
ENST00000450220.2 [Q5SQI0-4]
ENST00000416917.5 [Q5SQI0-7]
ENST00000456215.6 [Q5SQI0-4]
ENST00000383582.4 [Q5SQI0-2]
ENST00000400575.5 [Q5SQI0-5]
ENST00000430611.5 [Q5SQI0-6]
ENST00000417183.5 [Q5SQI0-7]
ENST00000329992.12 [Q5SQI0-4]
ENST00000383585.8 [Q5SQI0-1]
ENST00000446100.5 [Q5SQI0-5]
ENST00000376485.9 [Q5SQI0-1]
ENST00000318999.11 [Q5SQI0-7]
ENST00000319027.9 [Q5SQI0-6]