ANXA6 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	39 studies	41% ± 17%	Explore
CD8-positive, alpha-beta T cell	35 studies	40% ± 18%	Explore
B cell	31 studies	35% ± 14%	Explore
fibroblast	30 studies	33% ± 15%	Explore
CD4-positive, alpha-beta T cell	30 studies	37% ± 15%	Explore
T cell	26 studies	34% ± 15%	Explore
pericyte	26 studies	39% ± 18%	Explore
smooth muscle cell	26 studies	38% ± 19%	Explore
regulatory T cell	23 studies	36% ± 14%	Explore
mature NK T cell	19 studies	43% ± 17%	Explore
memory B cell	19 studies	38% ± 12%	Explore
naive B cell	18 studies	36% ± 13%	Explore
gamma-delta T cell	16 studies	41% ± 18%	Explore
conventional dendritic cell	15 studies	26% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	51% ± 15%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	45% ± 16%	Explore
endothelial cell	14 studies	27% ± 10%	Explore
dendritic cell	14 studies	44% ± 17%	Explore
classical monocyte	13 studies	27% ± 10%	Explore
myofibroblast cell	13 studies	45% ± 15%	Explore
mucosal invariant T cell	12 studies	36% ± 14%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	32% ± 12%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	37% ± 12%	Explore
plasma cell	12 studies	37% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	37% ± 17%	Explore
connective tissue cell	12 studies	36% ± 16%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	36% ± 18%	Explore
mast cell	10 studies	20% ± 4%	Explore
plasmablast	10 studies	41% ± 22%	Explore
adipocyte	10 studies	28% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	45% ± 15%	Explore
innate lymphoid cell	8 studies	29% ± 17%	Explore
plasmacytoid dendritic cell	7 studies	23% ± 5%	Explore
monocyte	7 studies	22% ± 10%	Explore
glutamatergic neuron	6 studies	37% ± 22%	Explore
retinal rod cell	6 studies	28% ± 5%	Explore
T follicular helper cell	6 studies	29% ± 9%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	50% ± 24%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	46% ± 16%	Explore
hematopoietic precursor cell	5 studies	29% ± 9%	Explore
exhausted T cell	5 studies	54% ± 12%	Explore
neuron	5 studies	29% ± 14%	Explore
retinal ganglion cell	5 studies	75% ± 26%	Explore
T-helper 17 cell	5 studies	40% ± 23%	Explore
immature B cell	5 studies	45% ± 17%	Explore
astrocyte	5 studies	24% ± 8%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	50% ± 20%	Explore
macrophage	4 studies	28% ± 6%	Explore
lymphocyte	4 studies	36% ± 8%	Explore
myeloid cell	4 studies	24% ± 4%	Explore
adventitial cell	4 studies	28% ± 8%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	64% ± 8%	Explore
CD4-positive helper T cell	3 studies	24% ± 5%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	47% ± 18%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	38% ± 19%	Explore
pancreatic A cell	3 studies	36% ± 18%	Explore
non-classical monocyte	3 studies	20% ± 2%	Explore
progenitor cell	3 studies	25% ± 7%	Explore
precursor B cell	3 studies	39% ± 2%	Explore
intraepithelial lymphocyte	3 studies	31% ± 20%	Explore
abnormal cell	3 studies	23% ± 10%	Explore
epithelial cell	3 studies	24% ± 6%	Explore
muscle cell	3 studies	42% ± 21%	Explore
GABAergic neuron	3 studies	45% ± 7%	Explore
granulocyte	3 studies	23% ± 9%	Explore
leukocyte	3 studies	25% ± 4%	Explore
group 3 innate lymphoid cell	3 studies	40% ± 18%	Explore
T-helper 1 cell	3 studies	49% ± 16%	Explore
hematopoietic stem cell	3 studies	30% ± 2%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	42% ± 20%	Explore
double negative thymocyte	3 studies	53% ± 6%	Explore
interneuron	3 studies	36% ± 20%	Explore
hepatocyte	3 studies	37% ± 20%	Explore
oligodendrocyte precursor cell	3 studies	29% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	17 studies	33% ± 10%	Explore
lung	8 studies	27% ± 12%	Explore
eye	8 studies	20% ± 2%	Explore
brain	6 studies	29% ± 13%	Explore
intestine	5 studies	25% ± 11%	Explore
kidney	4 studies	29% ± 10%	Explore
bone marrow	4 studies	23% ± 10%	Explore
lymph node	4 studies	26% ± 9%	Explore
liver	4 studies	19% ± 3%	Explore
pancreas	3 studies	30% ± 14%	Explore
adipose	3 studies	32% ± 13%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	22066.25	459 / 459	99%	200.94	1111 / 1118
thymus	100%	10723.81	651 / 653	99%	111.56	601 / 605
adrenal gland	100%	14791.15	257 / 258	99%	185.23	227 / 230
liver	99%	10774.58	224 / 226	96%	107.73	388 / 406
kidney	98%	7629.39	87 / 89	95%	100.50	860 / 901
prostate	98%	11932.17	241 / 245	94%	75.16	471 / 502
brain	90%	9139.60	2387 / 2642	100%	153.28	705 / 705
intestine	99%	17016.87	952 / 966	89%	67.84	469 / 527
lung	100%	15840.08	577 / 578	88%	61.99	1013 / 1155
skin	86%	13861.53	1564 / 1809	97%	134.59	456 / 472
ovary	100%	18331.12	180 / 180	79%	41.39	340 / 430
stomach	92%	10631.01	329 / 359	87%	67.56	248 / 286
pancreas	83%	4064.57	271 / 328	95%	117.96	169 / 178
uterus	99%	19038.14	169 / 170	74%	87.53	339 / 459
bladder	100%	23524.81	21 / 21	69%	52.87	349 / 504
esophagus	85%	15896.36	1230 / 1445	56%	25.48	102 / 183
adipose	100%	24795.61	1204 / 1204	0%	0	0 / 0
blood vessel	100%	22357.82	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	169.43	80 / 80
lymph node	0%	0	0 / 0	100%	219.35	29 / 29
spleen	100%	16726.80	241 / 241	0%	0	0 / 0
muscle	100%	13594.64	802 / 803	0%	0	0 / 0
peripheral blood	97%	21286.27	901 / 929	0%	0	0 / 0
heart	96%	12410.95	824 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	89%	62.42	40 / 45
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0097190	Biological process	apoptotic signaling pathway
GO_0051283	Biological process	negative regulation of sequestering of calcium ion
GO_0006937	Biological process	regulation of muscle contraction
GO_0034220	Biological process	monoatomic ion transmembrane transport
GO_0051560	Biological process	mitochondrial calcium ion homeostasis
GO_0006816	Biological process	calcium ion transport
GO_0031902	Cellular component	late endosome membrane
GO_0012506	Cellular component	vesicle membrane
GO_0016020	Cellular component	membrane
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005739	Cellular component	mitochondrion
GO_0042383	Cellular component	sarcolemma
GO_0070062	Cellular component	extracellular exosome
GO_0062023	Cellular component	collagen-containing extracellular matrix
GO_0005925	Cellular component	focal adhesion
GO_0005737	Cellular component	cytoplasm
GO_0042470	Cellular component	melanosome
GO_0005765	Cellular component	lysosomal membrane
GO_0015485	Molecular function	cholesterol binding
GO_0005544	Molecular function	calcium-dependent phospholipid binding
GO_0008289	Molecular function	lipid binding
GO_0015276	Molecular function	ligand-gated monoatomic ion channel activity
GO_0001786	Molecular function	phosphatidylserine binding
GO_0042802	Molecular function	identical protein binding
GO_0005525	Molecular function	GTP binding
GO_0048306	Molecular function	calcium-dependent protein binding
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	ANXA6
Protein name	Annexin A6 Annexin A7 (Annexin VII) (Annexin-7) Annexin Annexin A6 (67 kDa calelectrin) (Annexin VI) (Annexin-6) (Calphobindin-II) (CPB-II) (Chromobindin-20) (Lipocortin VI) (Protein III) (p68) (p70)
Synonyms	hCG_39152 ANX6
Description	FUNCTION: May associate with CD21. May regulate the release of Ca(2+) from intracellular stores. FUNCTION: May associate with CD21. May regulate the release of Ca(2+) from intracellular stores. . FUNCTION: May associate with CD21. May regulate the release of Ca(2+) from intracellular stores. . FUNCTION: May associate with CD21. May regulate the release of Ca(2+) from intracellular stores. . FUNCTION: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. . FUNCTION: May associate with CD21. May regulate the release of Ca(2+) from intracellular stores. . FUNCTION: May associate with CD21. May regulate the release of Ca(2+) from intracellular stores. . FUNCTION: May associate with CD21. May regulate the release of Ca(2+) from intracellular stores. . FUNCTION: May associate with CD21. May regulate the release of Ca(2+) from intracellular stores. . FUNCTION: May associate with CD21. May regulate the release of Ca(2+) from intracellular stores. .
Accessions	ENST00000700367.1 A0A0S2Z377 ENST00000519644.6 E5RI05 E5RK69 ENST00000517677.5 E5RFF0 ENST00000523164.1 E7EMC6 A0A0S2Z2Z6 ENST00000517757.5 E5RK63 ENST00000521512.5 ENST00000517486.5 ENST00000377751.9 ENST00000354546.10 [P08133-1] A0A0S2Z301 E5RJF5 E5RIU8 H0YC77 E5RJR0 P08133 ENST00000522664.5 ENST00000521749.5 ENST00000523714.5 [P08133-2]

ANXA6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review