NECTIN2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0033005Biological processpositive regulation of mast cell activation
GO_0050862Biological processpositive regulation of T cell receptor signaling pathway
GO_0045954Biological processpositive regulation of natural killer cell mediated cytotoxicity
GO_0060370Biological processsusceptibility to T cell mediated cytotoxicity
GO_0002891Biological processpositive regulation of immunoglobulin mediated immune response
GO_0007010Biological processcytoskeleton organization
GO_0007289Biological processspermatid nucleus differentiation
GO_0051649Biological processestablishment of localization in cell
GO_0046718Biological processsymbiont entry into host cell
GO_0009566Biological processfertilization
GO_0019064Biological processfusion of virus membrane with host plasma membrane
GO_0007156Biological processhomophilic cell adhesion via plasma membrane adhesion molecules
GO_0001675Biological processacrosome assembly
GO_0044782Biological processcilium organization
GO_0044406Biological processadhesion of symbiont to host
GO_0030382Biological processsperm mitochondrion organization
GO_0002860Biological processpositive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO_0046814Biological processcoreceptor-mediated virion attachment to host cell
GO_0042271Biological processsusceptibility to natural killer cell mediated cytotoxicity
GO_0046596Biological processregulation of viral entry into host cell
GO_0007286Biological processspermatid development
GO_0051654Biological processestablishment of mitochondrion localization
GO_0005915Cellular componentzonula adherens
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0044291Cellular componentcell-cell contact zone
GO_0005925Cellular componentfocal adhesion
GO_0005911Cellular componentcell-cell junction
GO_0009986Cellular componentcell surface
GO_0043296Cellular componentapical junction complex
GO_0015026Molecular functioncoreceptor activity
GO_0042803Molecular functionprotein homodimerization activity
GO_0042802Molecular functionidentical protein binding
GO_0001618Molecular functionvirus receptor activity
GO_0050839Molecular functioncell adhesion molecule binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNECTIN2
Protein namePoliovirus receptor related 2
Nectin cell adhesion molecule 2
Nectin-2 (Herpes virus entry mediator B) (Herpesvirus entry mediator B) (HveB) (Nectin cell adhesion molecule 2) (Poliovirus receptor-related protein 2) (CD antigen CD112)
SynonymsPRR2
HVEB
PVRL2
DescriptionFUNCTION: Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive . Probable cell adhesion protein . .; FUNCTION: (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV). .

AccessionsENST00000592018.1
Q7Z456
ENST00000591581.1
Q7Z458
ENST00000252483.10 [Q92692-1]
Q92692
K7EKE8
Q7Z457
K7EK87
K7ERL3
ENST00000252485.8 [Q92692-2]
ENST00000585601.1