ARF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006886Biological processintracellular protein transport
GO_0002090Biological processregulation of receptor internalization
GO_0060292Biological processlong-term synaptic depression
GO_1990386Biological processmitotic cleavage furrow ingression
GO_0098586Biological processcellular response to virus
GO_0016192Biological processvesicle-mediated transport
GO_0097061Biological processdendritic spine organization
GO_0006878Biological processintracellular copper ion homeostasis
GO_0034315Biological processregulation of Arp2/3 complex-mediated actin nucleation
GO_0005886Cellular componentplasma membrane
GO_0032991Cellular componentprotein-containing complex
GO_0070062Cellular componentextracellular exosome
GO_0043005Cellular componentneuron projection
GO_0031252Cellular componentcell leading edge
GO_0005925Cellular componentfocal adhesion
GO_0000139Cellular componentGolgi membrane
GO_0030017Cellular componentsarcomere
GO_0005829Cellular componentcytosol
GO_0014069Cellular componentpostsynaptic density
GO_0005737Cellular componentcytoplasm
GO_0019904Molecular functionprotein domain specific binding
GO_0000287Molecular functionmagnesium ion binding
GO_0005525Molecular functionGTP binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameARF1
Protein nameADP-ribosylation factor 1
ADP ribosylation factor 1
ADP-ribosylation factor
ADP-ribosylation factor 1 (EC 3.6.5.2)
Synonyms
DescriptionFUNCTION: Small GTPase involved in protein trafficking between different compartments . Modulates vesicle budding and uncoating within the Golgi complex . In its GTP-bound form, triggers the recruitment of coatomer proteins to the Golgi membrane . The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles . The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasticity of excitatory synapses and spine shrinkage during long-term depression (LTD) (By similarity). Plays a key role in the regulation of intestinal stem cells and gut microbiota, and is essential for maintaining intestinal homeostasis (By similarity). Plays also a critical role in mast cell expansion but not in mast cell maturation by facilitating optimal mTORC1 activation (By similarity). .; FUNCTION: (Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. .

FUNCTION: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus. .

FUNCTION: GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus. .

AccessionsENST00000473949.5
A0A8V8TP92
A0A8V8TNZ5
P84077
ENST00000272102.10
ENST00000469235.5
ENST00000482962.5
ENST00000478336.5
ENST00000478424.5
A0A8V8TNZ0
ENST00000497165.5
ENST00000490705.2
A0A8V8TP99
ENST00000477451.5
ENST00000473546.1
A0A8V8TQC0
A0A8V8TPG9
ENST00000470558.5
A0A8V8TQP8