NCSTN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050673Biological processepithelial cell proliferation
GO_0007220Biological processNotch receptor processing
GO_0002262Biological processmyeloid cell homeostasis
GO_0031293Biological processmembrane protein intracellular domain proteolysis
GO_1900271Biological processregulation of long-term synaptic potentiation
GO_0007219Biological processNotch signaling pathway
GO_0042098Biological processT cell proliferation
GO_0007611Biological processlearning or memory
GO_0016485Biological processprotein processing
GO_1990926Biological processshort-term synaptic potentiation
GO_0022010Biological processcentral nervous system myelination
GO_0071277Biological processcellular response to calcium ion
GO_0034205Biological processamyloid-beta formation
GO_0051402Biological processneuron apoptotic process
GO_0042983Biological processamyloid precursor protein biosynthetic process
GO_0006508Biological processproteolysis
GO_0030534Biological processadult behavior
GO_0021549Biological processcerebellum development
GO_0042986Biological processpositive regulation of amyloid precursor protein biosynthetic process
GO_0042982Biological processamyloid precursor protein metabolic process
GO_0007215Biological processglutamate receptor signaling pathway
GO_0007212Biological processG protein-coupled dopamine receptor signaling pathway
GO_0010950Biological processpositive regulation of endopeptidase activity
GO_0042987Biological processamyloid precursor protein catabolic process
GO_0006509Biological processmembrane protein ectodomain proteolysis
GO_0070765Cellular componentgamma-secretase complex
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005769Cellular componentearly endosome
GO_0035577Cellular componentazurophil granule membrane
GO_0042383Cellular componentsarcolemma
GO_0070062Cellular componentextracellular exosome
GO_0005794Cellular componentGolgi apparatus
GO_0042734Cellular componentpresynaptic membrane
GO_0005925Cellular componentfocal adhesion
GO_0000139Cellular componentGolgi membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0008021Cellular componentsynaptic vesicle
GO_0010008Cellular componentendosome membrane
GO_0042470Cellular componentmelanosome
GO_0005765Cellular componentlysosomal membrane
GO_0042500Molecular functionaspartic endopeptidase activity, intramembrane cleaving
GO_0070851Molecular functiongrowth factor receptor binding
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0051117Molecular functionATPase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNCSTN
Protein nameNicastrin
SynonymsKIAA0253
UNQ1874/PRO4317
DescriptionFUNCTION: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) . The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. .

AccessionsENST00000294785.10 [Q92542-1]
A0A8V8TNU8
ENST00000424645.6
A0A8V8TPR8
H0Y6T7
A0A8V8TNI3
ENST00000699549.1
Q92542
ENST00000437169.5
ENST00000699530.1
ENST00000467837.5
Q5T210
A0A2R8YCK1
ENST00000699532.1
Q5T209
ENST00000699554.1
A0A8V8TNV3
ENST00000459963.6
ENST00000699543.1
ENST00000699540.1
ENST00000699538.1
A0A8V8TNV7
ENST00000438008.5
A0A2R8YE20
ENST00000368063.6
A0A8V8TNI9
ENST00000699546.1
ENST00000699553.1
H0Y3Z4
ENST00000699528.1
A0A8V8TPQ8
ENST00000421914.6
A0A8V8TNC8
Q5T211
A0A2U3TZL9
ENST00000699541.1
ENST00000699527.1
ENST00000435149.1
A0A8V8TQ51
Q5T205
ENST00000424754.5
ENST00000699545.1
A0A8V8TQ61