SYNE2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051642Biological processcentrosome localization
GO_0031022Biological processnuclear migration along microfilament
GO_1902017Biological processregulation of cilium assembly
GO_0030335Biological processpositive regulation of cell migration
GO_0007097Biological processnuclear migration
GO_0021817Biological processnucleokinesis involved in cell motility in cerebral cortex radial glia guided migration
GO_0030018Cellular componentZ disc
GO_0005739Cellular componentmitochondrion
GO_0070062Cellular componentextracellular exosome
GO_0005634Cellular componentnucleus
GO_0005654Cellular componentnucleoplasm
GO_0005640Cellular componentnuclear outer membrane
GO_0005635Cellular componentnuclear envelope
GO_0005925Cellular componentfocal adhesion
GO_0045111Cellular componentintermediate filament cytoskeleton
GO_0034993Cellular componentmeiotic nuclear membrane microtubule tethering complex
GO_0031527Cellular componentfilopodium membrane
GO_0031258Cellular componentlamellipodium membrane
GO_0016529Cellular componentsarcoplasmic reticulum
GO_0031981Cellular componentnuclear lumen
GO_0005737Cellular componentcytoplasm
GO_0033017Cellular componentsarcoplasmic reticulum membrane
GO_0031965Cellular componentnuclear membrane
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding
GO_0140444Molecular functioncytoskeleton-nuclear membrane anchor activity

IV. Literature review

[source]
Gene nameSYNE2
Protein nameNesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2)
Spectrin repeat containing nuclear envelope protein 2
Nesprin-2
SynonymsNUA
KIAA1011
DescriptionFUNCTION: Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning . Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome; SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis. Facilitates the relaxation of mechanical stress imposed by compressive actin fibers at the rupture site through its nteraction with SYN2 . .

AccessionsG3V3D4
Q8WXH0
ENST00000555002.6 [Q8WXH0-2]
G3V2Q0
A0A669KB61
A0A669KB22
ENST00000344113.8 [Q8WXH0-1]
ENST00000555002
ENST00000673869.1
G3V4T3
ENST00000458046.6 [Q8WXH0-5]
G3V5N1
A0A1W2PS37
ENST00000555612.5
G3V5X4
ENST00000553801.1
ENST00000553455.1
ENST00000673797.1
A0A669KBG2
A0A669KBH2
A0A1W2PRN9
ENST00000553289.5
ENST00000358025.7 [Q8WXH0-2]
ENST00000555241.5
ENST00000341472.9 [Q8WXH0-8]
A0A0C4DGK3
ENST00000674144.1
ENST00000554584.5
ENST00000557084.1
ENST00000674003.1