ITGB8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0033627Biological processcell adhesion mediated by integrin
GO_0010629Biological processnegative regulation of gene expression
GO_0001573Biological processganglioside metabolic process
GO_0045766Biological processpositive regulation of angiogenesis
GO_0007160Biological processcell-matrix adhesion
GO_0009615Biological processresponse to virus
GO_0010628Biological processpositive regulation of gene expression
GO_0001570Biological processvasculogenesis
GO_0007155Biological processcell adhesion
GO_0006955Biological processimmune response
GO_0007229Biological processintegrin-mediated signaling pathway
GO_0060674Biological processplacenta blood vessel development
GO_0060022Biological processhard palate development
GO_0098609Biological processcell-cell adhesion
GO_0007179Biological processtransforming growth factor beta receptor signaling pathway
GO_0051216Biological processcartilage development
GO_0016477Biological processcell migration
GO_0061520Biological processLangerhans cell differentiation
GO_0005886Cellular componentplasma membrane
GO_0008305Cellular componentintegrin complex
GO_0070062Cellular componentextracellular exosome
GO_0005925Cellular componentfocal adhesion
GO_0034686Cellular componentintegrin alphav-beta8 complex
GO_0009986Cellular componentcell surface
GO_1990430Molecular functionextracellular matrix protein binding
GO_0005178Molecular functionintegrin binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameITGB8
Protein nameIntegrin beta
Integrin beta-8
SynonymshCG_37311
DescriptionFUNCTION: Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin . It recognizes the sequence R-G-D in its ligands . Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (Probable). Required during vasculogenesis (By similarity). .

AccessionsP26012
ENST00000537992.5 [P26012-2]
Q9BUG9
ENST00000222573.5 [P26012-1]