PPIB | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	39 studies	44% ± 17%	Explore
natural killer cell	39 studies	62% ± 18%	Explore
fibroblast	38 studies	68% ± 21%	Explore
endothelial cell	37 studies	56% ± 21%	Explore
macrophage	35 studies	58% ± 17%	Explore
CD8-positive, alpha-beta T cell	35 studies	58% ± 22%	Explore
T cell	30 studies	53% ± 18%	Explore
pericyte	29 studies	63% ± 21%	Explore
CD4-positive, alpha-beta T cell	29 studies	60% ± 18%	Explore
conventional dendritic cell	28 studies	70% ± 14%	Explore
plasmacytoid dendritic cell	27 studies	86% ± 13%	Explore
plasma cell	26 studies	71% ± 26%	Explore
smooth muscle cell	26 studies	54% ± 19%	Explore
classical monocyte	25 studies	57% ± 18%	Explore
regulatory T cell	25 studies	61% ± 17%	Explore
dendritic cell	24 studies	58% ± 26%	Explore
non-classical monocyte	23 studies	59% ± 18%	Explore
mature NK T cell	22 studies	57% ± 20%	Explore
epithelial cell	21 studies	62% ± 22%	Explore
mast cell	20 studies	43% ± 16%	Explore
memory B cell	20 studies	46% ± 18%	Explore
basal cell	20 studies	59% ± 19%	Explore
monocyte	19 studies	51% ± 16%	Explore
connective tissue cell	19 studies	74% ± 17%	Explore
endothelial cell of lymphatic vessel	18 studies	59% ± 17%	Explore
gamma-delta T cell	18 studies	63% ± 16%	Explore
naive B cell	18 studies	42% ± 12%	Explore
mucosal invariant T cell	16 studies	64% ± 21%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	16 studies	51% ± 15%	Explore
ciliated cell	16 studies	49% ± 23%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	62% ± 21%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	70% ± 18%	Explore
myofibroblast cell	14 studies	68% ± 22%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	63% ± 15%	Explore
myeloid cell	13 studies	59% ± 20%	Explore
plasmablast	12 studies	87% ± 11%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	62% ± 21%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	63% ± 20%	Explore
secretory cell	12 studies	67% ± 17%	Explore
capillary endothelial cell	12 studies	54% ± 16%	Explore
endothelial cell of artery	12 studies	55% ± 17%	Explore
mesothelial cell	11 studies	72% ± 28%	Explore
vein endothelial cell	11 studies	59% ± 16%	Explore
endothelial cell of vascular tree	11 studies	51% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	65% ± 16%	Explore
progenitor cell	10 studies	68% ± 23%	Explore
goblet cell	10 studies	51% ± 19%	Explore
type I pneumocyte	9 studies	49% ± 21%	Explore
type II pneumocyte	9 studies	61% ± 24%	Explore
leukocyte	9 studies	52% ± 16%	Explore
abnormal cell	9 studies	67% ± 15%	Explore
innate lymphoid cell	8 studies	57% ± 14%	Explore
club cell	8 studies	59% ± 22%	Explore
IgG plasma cell	8 studies	64% ± 16%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	75% ± 22%	Explore
astrocyte	7 studies	32% ± 16%	Explore
epithelial cell of proximal tubule	7 studies	45% ± 20%	Explore
IgA plasma cell	7 studies	71% ± 19%	Explore
hematopoietic stem cell	7 studies	60% ± 23%	Explore
neuron	7 studies	54% ± 24%	Explore
T follicular helper cell	7 studies	55% ± 13%	Explore
alveolar macrophage	6 studies	52% ± 16%	Explore
hematopoietic precursor cell	6 studies	63% ± 20%	Explore
respiratory goblet cell	6 studies	55% ± 22%	Explore
platelet	6 studies	30% ± 11%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	72% ± 25%	Explore
mononuclear phagocyte	6 studies	53% ± 24%	Explore
kidney loop of Henle epithelial cell	6 studies	46% ± 18%	Explore
renal alpha-intercalated cell	6 studies	66% ± 10%	Explore
oligodendrocyte	6 studies	26% ± 12%	Explore
enterocyte	6 studies	48% ± 14%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	71% ± 17%	Explore
CD4-positive helper T cell	5 studies	49% ± 17%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	66% ± 14%	Explore
exhausted T cell	5 studies	81% ± 8%	Explore
ionocyte	5 studies	55% ± 10%	Explore
intestinal crypt stem cell	5 studies	45% ± 20%	Explore
precursor B cell	5 studies	60% ± 10%	Explore
neuroendocrine cell	5 studies	68% ± 21%	Explore
T-helper 17 cell	5 studies	65% ± 24%	Explore
group 3 innate lymphoid cell	5 studies	72% ± 11%	Explore
immature B cell	5 studies	63% ± 10%	Explore
mucus secreting cell	5 studies	43% ± 18%	Explore
double negative thymocyte	5 studies	72% ± 15%	Explore
granulocyte	5 studies	42% ± 10%	Explore
oligodendrocyte precursor cell	5 studies	47% ± 19%	Explore
erythrocyte	5 studies	53% ± 14%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	64% ± 15%	Explore
deuterosomal cell	4 studies	39% ± 14%	Explore
duct epithelial cell	4 studies	69% ± 8%	Explore
pancreatic A cell	4 studies	71% ± 24%	Explore
glomerular endothelial cell	4 studies	57% ± 8%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	73% ± 17%	Explore
enteroendocrine cell	4 studies	73% ± 17%	Explore
transit amplifying cell	4 studies	57% ± 18%	Explore
erythroblast	4 studies	37% ± 17%	Explore
pro-B cell	4 studies	48% ± 15%	Explore
brush cell	4 studies	33% ± 19%	Explore
microglial cell	4 studies	46% ± 18%	Explore
adventitial cell	4 studies	76% ± 14%	Explore
neutrophil	4 studies	23% ± 7%	Explore
intermediate monocyte	4 studies	76% ± 9%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	66% ± 11%	Explore
luminal cell of prostate epithelium	4 studies	40% ± 13%	Explore
hepatocyte	4 studies	48% ± 29%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	78% ± 13%	Explore
precursor cell	3 studies	88% ± 8%	Explore
type B pancreatic cell	3 studies	78% ± 14%	Explore
monocyte-derived dendritic cell	3 studies	57% ± 28%	Explore
podocyte	3 studies	72% ± 16%	Explore
neural crest cell	3 studies	70% ± 0%	Explore
renal principal cell	3 studies	65% ± 18%	Explore
extravillous trophoblast	3 studies	97% ± 1%	Explore
placental villous trophoblast	3 studies	97% ± 2%	Explore
common myeloid progenitor	3 studies	69% ± 18%	Explore
lymphocyte	3 studies	70% ± 12%	Explore
megakaryocyte	3 studies	44% ± 4%	Explore
retinal cone cell	3 studies	28% ± 11%	Explore
serous secreting cell	3 studies	56% ± 2%	Explore
tissue-resident macrophage	3 studies	46% ± 22%	Explore
intraepithelial lymphocyte	3 studies	54% ± 17%	Explore
Mueller cell	3 studies	34% ± 8%	Explore
acinar cell	3 studies	51% ± 13%	Explore
endothelial cell of sinusoid	3 studies	42% ± 23%	Explore
muscle cell	3 studies	43% ± 10%	Explore
germinal center B cell	3 studies	44% ± 9%	Explore
myoepithelial cell	3 studies	69% ± 22%	Explore
inflammatory macrophage	3 studies	32% ± 15%	Explore
IgM plasma cell	3 studies	73% ± 7%	Explore
GABAergic neuron	3 studies	28% ± 5%	Explore
glutamatergic neuron	3 studies	34% ± 6%	Explore
granulocyte monocyte progenitor cell	3 studies	83% ± 10%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	60% ± 33%	Explore
glial cell	3 studies	62% ± 25%	Explore
keratinocyte	3 studies	33% ± 9%	Explore
interneuron	3 studies	42% ± 26%	Explore
T-helper 1 cell	3 studies	79% ± 14%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	69% ± 14%	Explore
double-positive, alpha-beta thymocyte	3 studies	77% ± 8%	Explore
progenitor cell of mammary luminal epithelium	3 studies	66% ± 11%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	19 studies	60% ± 13%	Explore
lung	18 studies	54% ± 17%	Explore
intestine	12 studies	54% ± 23%	Explore
kidney	9 studies	54% ± 19%	Explore
brain	9 studies	33% ± 16%	Explore
bone marrow	6 studies	36% ± 22%	Explore
liver	6 studies	42% ± 15%	Explore
pancreas	5 studies	57% ± 29%	Explore
eye	5 studies	33% ± 11%	Explore
uterus	5 studies	65% ± 23%	Explore
lymph node	5 studies	59% ± 16%	Explore
placenta	4 studies	73% ± 30%	Explore
adipose	4 studies	35% ± 19%	Explore
prostate	4 studies	47% ± 13%	Explore
breast	4 studies	60% ± 4%	Explore
heart	3 studies	31% ± 13%	Explore
adrenal gland	3 studies	47% ± 15%	Explore
esophagus	3 studies	56% ± 26%	Explore
skin	3 studies	38% ± 5%	Explore
thymus	3 studies	61% ± 21%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
pancreas	100%	6680.57	328 / 328	100%	240.72	178 / 178
skin	100%	7529.50	1808 / 1809	100%	276.52	472 / 472
thymus	100%	9478.70	653 / 653	100%	285.47	604 / 605
prostate	100%	5365.59	245 / 245	100%	395.26	501 / 502
uterus	100%	6801.44	170 / 170	100%	259.54	458 / 459
ovary	100%	7235.22	180 / 180	100%	201.70	429 / 430
kidney	100%	5113.09	89 / 89	100%	186.00	898 / 901
liver	100%	6628.21	225 / 226	100%	268.62	406 / 406
intestine	100%	4409.85	966 / 966	99%	230.44	524 / 527
lung	100%	7013.32	577 / 578	100%	226.06	1150 / 1155
stomach	100%	4527.75	359 / 359	99%	177.24	284 / 286
breast	100%	6133.56	459 / 459	99%	224.38	1109 / 1118
esophagus	100%	4132.39	1444 / 1445	99%	106.39	181 / 183
bladder	100%	5387.14	21 / 21	99%	251.87	497 / 504
adrenal gland	100%	6754.39	258 / 258	98%	185.25	226 / 230
brain	92%	1875.65	2437 / 2642	99%	157.22	700 / 705
adipose	100%	6489.70	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	209.98	29 / 29
spleen	100%	6319.05	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	164.16	45 / 45
ureter	0%	0	0 / 0	100%	169.82	1 / 1
blood vessel	100%	6793.29	1333 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	99%	219.67	79 / 80
peripheral blood	98%	4737.36	907 / 929	0%	0	0 / 0
heart	90%	2780.07	779 / 861	0%	0	0 / 0
muscle	20%	297.40	162 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0061077	Biological process	chaperone-mediated protein folding
GO_0044829	Biological process	positive regulation by host of viral genome replication
GO_0030593	Biological process	neutrophil chemotaxis
GO_0044794	Biological process	positive regulation by host of viral process
GO_0006457	Biological process	protein folding
GO_0050821	Biological process	protein stabilization
GO_1901873	Biological process	regulation of post-translational protein modification
GO_0060348	Biological process	bone development
GO_0040018	Biological process	positive regulation of multicellular organism growth
GO_0000413	Biological process	protein peptidyl-prolyl isomerization
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0016020	Cellular component	membrane
GO_0005790	Cellular component	smooth endoplasmic reticulum
GO_0070062	Cellular component	extracellular exosome
GO_0032991	Cellular component	protein-containing complex
GO_0005654	Cellular component	nucleoplasm
GO_0005925	Cellular component	focal adhesion
GO_0005788	Cellular component	endoplasmic reticulum lumen
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005829	Cellular component	cytosol
GO_0034663	Cellular component	endoplasmic reticulum chaperone complex
GO_0005737	Cellular component	cytoplasm
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0042470	Cellular component	melanosome
GO_0005634	Cellular component	nucleus
GO_0070063	Molecular function	RNA polymerase binding
GO_0003755	Molecular function	peptidyl-prolyl cis-trans isomerase activity
GO_0051082	Molecular function	unfolded protein binding
GO_0003723	Molecular function	RNA binding
GO_0005518	Molecular function	collagen binding
GO_0005515	Molecular function	protein binding
GO_0016018	Molecular function	cyclosporin A binding

IV. Literature review

[source]

Gene name	PPIB
Protein name	Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8)
Synonyms	CYPB
Description	FUNCTION: PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. . FUNCTION: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. . FUNCTION: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. . FUNCTION: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. .
Accessions	A0A7P0TB45 ENST00000680158.1 ENST00000300026.4 P23284 ENST00000681658.1 ENST00000681397.1 A0A7P0T7U3 A0A7P0Z497

PPIB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review