PIK3R2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PIK3R2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PIK3R2 at tissue level.

III. Associated gene sets

GO_0032869Biological processcellular response to insulin stimulus
GO_0030833Biological processregulation of actin filament polymerization
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_0042307Biological processpositive regulation of protein import into nucleus
GO_0046854Biological processphosphatidylinositol phosphate biosynthetic process
GO_0045785Biological processpositive regulation of cell adhesion
GO_0001678Biological processintracellular glucose homeostasis
GO_0006955Biological processimmune response
GO_0030217Biological processT cell differentiation
GO_0008286Biological processinsulin receptor signaling pathway
GO_0010506Biological processregulation of autophagy
GO_0051492Biological processregulation of stress fiber assembly
GO_0043409Biological processnegative regulation of MAPK cascade
GO_0043491Biological processphosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0015031Biological processprotein transport
GO_1903076Biological processregulation of protein localization to plasma membrane
GO_0030183Biological processB cell differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005942Cellular componentphosphatidylinositol 3-kinase complex
GO_0005925Cellular componentfocal adhesion
GO_0005943Cellular componentphosphatidylinositol 3-kinase complex, class IA
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0019903Molecular functionprotein phosphatase binding
GO_0046935Molecular function1-phosphatidylinositol-3-kinase regulator activity
GO_0046982Molecular functionprotein heterodimerization activity
GO_0036312Molecular functionphosphatidylinositol 3-kinase regulatory subunit binding
GO_0001784Molecular functionphosphotyrosine residue binding
GO_0005515Molecular functionprotein binding
GO_0030971Molecular functionreceptor tyrosine kinase binding

IV. Literature review

[source]
Gene namePIK3R2
Protein namePhosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
PIK3R2 protein
Phosphoinositide-3-kinase regulatory subunit 2
Synonyms
DescriptionFUNCTION: Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy . Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity). .

AccessionsQ96CK7
Q05BV6
A0A7I2U3A3
Q96EV4
A0A5F9ZHY3
ENST00000617642.2
E9PFP1
ENST00000464016.3
ENST00000426902.5
ENST00000222254.13
ENST00000617130.5
O00459
A0A087X257
V9GYJ4
ENST00000672815.1