ADAM10 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0099173Biological processpostsynapse organization
GO_0034332Biological processadherens junction organization
GO_0042117Biological processmonocyte activation
GO_0007219Biological processNotch signaling pathway
GO_0001701Biological processin utero embryonic development
GO_0010629Biological processnegative regulation of gene expression
GO_0030307Biological processpositive regulation of cell growth
GO_0038004Biological processepidermal growth factor receptor ligand maturation
GO_0010820Biological processpositive regulation of T cell chemotaxis
GO_0008593Biological processregulation of Notch signaling pathway
GO_0051089Biological processconstitutive protein ectodomain proteolysis
GO_0007162Biological processnegative regulation of cell adhesion
GO_0016485Biological processprotein processing
GO_0022617Biological processextracellular matrix disassembly
GO_0034612Biological processresponse to tumor necrosis factor
GO_0046931Biological processpore complex assembly
GO_0007267Biological processcell-cell signaling
GO_0140249Biological processprotein catabolic process at postsynapse
GO_0007229Biological processintegrin-mediated signaling pathway
GO_0030335Biological processpositive regulation of cell migration
GO_0090102Biological processcochlea development
GO_0098696Biological processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0006468Biological processprotein phosphorylation
GO_1901342Biological processregulation of vasculature development
GO_0042987Biological processamyloid precursor protein catabolic process
GO_0006509Biological processmembrane protein ectodomain proteolysis
GO_0099175Biological processregulation of postsynapse organization
GO_0098978Cellular componentglutamatergic synapse
GO_0035579Cellular componentspecific granule membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0097060Cellular componentsynaptic membrane
GO_0070062Cellular componentextracellular exosome
GO_0030136Cellular componentclathrin-coated vesicle
GO_0005794Cellular componentGolgi apparatus
GO_0097038Cellular componentperinuclear endoplasmic reticulum
GO_0005925Cellular componentfocal adhesion
GO_0030425Cellular componentdendrite
GO_0009986Cellular componentcell surface
GO_0000139Cellular componentGolgi membrane
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005912Cellular componentadherens junction
GO_0070821Cellular componenttertiary granule membrane
GO_0046930Cellular componentpore complex
GO_0014069Cellular componentpostsynaptic density
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0030424Cellular componentaxon
GO_0005798Cellular componentGolgi-associated vesicle
GO_0097197Cellular componenttetraspanin-enriched microdomain
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0004175Molecular functionendopeptidase activity
GO_1902945Molecular functionmetalloendopeptidase activity involved in amyloid precursor protein catabolic process
GO_0060090Molecular functionmolecular adaptor activity
GO_0008237Molecular functionmetallopeptidase activity
GO_0070573Molecular functionmetallodipeptidase activity
GO_0019901Molecular functionprotein kinase binding
GO_0005102Molecular functionsignaling receptor binding
GO_0005178Molecular functionintegrin binding
GO_0046872Molecular functionmetal ion binding
GO_0004222Molecular functionmetalloendopeptidase activity
GO_0005515Molecular functionprotein binding
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene nameADAM10
Protein nameDisintegrin and metalloproteinase domain-containing protein 10 (ADAM 10) (EC 3.4.24.81) (CDw156) (Kuzbanian protein homolog) (Mammalian disintegrin-metalloprotease) (CD antigen CD156c)
Disintegrin and metalloproteinase domain-containing protein 10 (Kuzbanian protein homolog)
ADAM metallopeptidase domain 10
Alternative protein ADAM10
SynonymsMADM
KUZ
DescriptionFUNCTION: Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins, including adhesion proteins, growth factor precursors and cytokines being essential for development and tissue homeostasis . Associates with six members of the tetraspanin superfamily TspanC8 which regulate its exit from the endoplasmic reticulum and its substrate selectivity . Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface . Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) . Contributes to the normal cleavage of the cellular prion protein . Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity . Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity). Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form . Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B . Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3 (By similarity). Mediates the proteolytic cleavage of IL6R and IL11RA, leading to the release of secreted forms of IL6R and IL11RA . Enhances the cleavage of CHL1 by BACE1 (By similarity). Cleaves NRCAM (By similarity). Cleaves TREM2, resulting in shedding of the TREM2 ectodomain . Involved in the development and maturation of glomerular and coronary vasculature (By similarity). During development of the cochlear organ of Corti, promotes pillar cell separation by forming a ternary complex with CADH1 and EPHA4 and cleaving CADH1 at adherens junctions (By similarity). May regulate the EFNA5-EPHA3 signaling . Regulates leukocyte transmigration as a sheddase for the adherens junction protein VE-cadherin/CDH5 in endothelial cells . .; FUNCTION: (Microbial infection) Promotes the cytotoxic activity of S.aureus hly by binding to the toxin at zonula adherens and promoting formation of toxin pores. .

AccessionsH3BS53
ENST00000396136.6
ENST00000561288.1
C9J9B4
ENST00000559053.1
ENST00000402627.5
B5MC71
ENST00000439637.5
H0YK87
ENST00000558004.1
ENST00000461408.2
H0YK32
L8E9R5
H0YNC5
O14672
A0AV88
ENST00000260408.8 [O14672-1]
A0A087WYG1