MISP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0090307Biological processmitotic spindle assembly
GO_0000132Biological processestablishment of mitotic spindle orientation
GO_0051301Biological processcell division
GO_1904776Biological processregulation of protein localization to cell cortex
GO_0016477Biological processcell migration
GO_0051660Biological processestablishment of centrosome localization
GO_0051640Biological processorganelle localization
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0031616Cellular componentspindle pole centrosome
GO_1905721Cellular componentmitotic spindle astral microtubule end
GO_0030864Cellular componentcortical actin cytoskeleton
GO_0005886Cellular componentplasma membrane
GO_0005884Cellular componentactin filament
GO_0005925Cellular componentfocal adhesion
GO_0051015Molecular functionactin filament binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMISP
Protein nameMitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein)
SynonymsC19orf21
DescriptionFUNCTION: Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytospkeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus. .

AccessionsQ8IVT2
ENST00000215582.8