YWHAZ report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042149Biological processcellular response to glucose starvation
GO_0001525Biological processangiogenesis
GO_0008039Biological processsynaptic target recognition
GO_0030324Biological processlung development
GO_0070372Biological processregulation of ERK1 and ERK2 cascade
GO_0007165Biological processsignal transduction
GO_0051683Biological processestablishment of Golgi localization
GO_0090128Biological processregulation of synapse maturation
GO_0090168Biological processGolgi reassembly
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0035148Biological processtube formation
GO_0006605Biological processprotein targeting
GO_0045824Biological processnegative regulation of innate immune response
GO_0070371Biological processERK1 and ERK2 cascade
GO_0043066Biological processnegative regulation of apoptotic process
GO_0003016Biological processrespiratory system process
GO_1900181Biological processnegative regulation of protein localization to nucleus
GO_0008104Biological processprotein localization
GO_0006468Biological processprotein phosphorylation
GO_1904262Biological processnegative regulation of TORC1 signaling
GO_0031647Biological processregulation of protein stability
GO_0098978Cellular componentglutamatergic synapse
GO_0005615Cellular componentextracellular space
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0098686Cellular componenthippocampal mossy fiber to CA3 synapse
GO_0005925Cellular componentfocal adhesion
GO_0072562Cellular componentblood microparticle
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0042470Cellular componentmelanosome
GO_0031982Cellular componentvesicle
GO_0005634Cellular componentnucleus
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0019904Molecular functionprotein domain specific binding
GO_0045296Molecular functioncadherin binding
GO_0019901Molecular functionprotein kinase binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0042802Molecular functionidentical protein binding
GO_0044325Molecular functiontransmembrane transporter binding
GO_0003723Molecular functionRNA binding
GO_0140311Molecular functionprotein sequestering activity
GO_0050815Molecular functionphosphoserine residue binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameYWHAZ
Protein name14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
14-3-3 protein zeta/delta
SynonymsHEL-S-3
HEL4
HEL-S-93
DescriptionFUNCTION: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways . Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif . Binding generally results in the modulation of the activity of the binding partner . Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB . Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation . In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity). .

AccessionsE7EVZ2
ENST00000418997.1
E7EX29
P63104
D0PNI1
ENST00000522542.5 [P63104-2]
ENST00000395953.6 [P63104-1]
ENST00000523848.5
B0AZS6
E5RIR4
ENST00000395956.7 [P63104-1]
B7Z2E6
ENST00000523131.1
ENST00000395957.6 [P63104-1]
ENST00000395951.7 [P63104-1]
ENST00000437293.5
ENST00000521328.5
E9PD24
ENST00000521309.5
E5RGE1
ENST00000419477.6 [P63104-1]
ENST00000523938.1
ENST00000395948.6
ENST00000521607.5
ENST00000353245.7 [P63104-1]
ENST00000522819.5
H0YB80
ENST00000457309.2 [P63104-1]
E7ESK7
ENST00000395958.6 [P63104-1]