CHP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006813Biological processpotassium ion transport
GO_0006469Biological processnegative regulation of protein kinase activity
GO_0006611Biological processprotein export from nucleus
GO_0070885Biological processnegative regulation of calcineurin-NFAT signaling cascade
GO_0031122Biological processcytoplasmic microtubule organization
GO_0010923Biological processnegative regulation of phosphatase activity
GO_0071073Biological processpositive regulation of phospholipid biosynthetic process
GO_0061025Biological processmembrane fusion
GO_0042308Biological processnegative regulation of protein import into nucleus
GO_0061024Biological processmembrane organization
GO_0071468Biological processcellular response to acidic pH
GO_0032088Biological processnegative regulation of NF-kappaB transcription factor activity
GO_0032417Biological processpositive regulation of sodium:proton antiporter activity
GO_0001933Biological processnegative regulation of protein phosphorylation
GO_0031397Biological processnegative regulation of protein ubiquitination
GO_0051222Biological processpositive regulation of protein transport
GO_0050821Biological processprotein stabilization
GO_0022406Biological processmembrane docking
GO_0007264Biological processsmall GTPase-mediated signal transduction
GO_0090314Biological processpositive regulation of protein targeting to membrane
GO_0060050Biological processpositive regulation of protein glycosylation
GO_0051453Biological processregulation of intracellular pH
GO_0031953Biological processnegative regulation of protein autophosphorylation
GO_0001578Biological processmicrotubule bundle formation
GO_0035725Biological processsodium ion transmembrane transport
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0070062Cellular componentextracellular exosome
GO_0005925Cellular componentfocal adhesion
GO_0000139Cellular componentGolgi membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0005793Cellular componentendoplasmic reticulum-Golgi intermediate compartment
GO_0005737Cellular componentcytoplasm
GO_0030133Cellular componenttransport vesicle
GO_1990351Cellular componenttransporter complex
GO_0005634Cellular componentnucleus
GO_0004860Molecular functionprotein kinase inhibitor activity
GO_0019900Molecular functionkinase binding
GO_0015385Molecular functionsodium:proton antiporter activity
GO_0048306Molecular functioncalcium-dependent protein binding
GO_0015459Molecular functionpotassium channel regulator activity
GO_0008017Molecular functionmicrotubule binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCHP1
Protein nameCalcineurin B homologous protein 1 (Calcineurin B-like protein) (Calcium-binding protein CHP) (Calcium-binding protein p22) (EF-hand calcium-binding domain-containing protein p22)
Calcineurin like EF-hand protein 1
SynonymsCHP
DescriptionFUNCTION: Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent manner. .

AccessionsENST00000560784.5
ENST00000392151.6
ENST00000560965.1
ENST00000560397.5
H0YLX1
Q99653
H0YLY7
H0YNG9
H0YKE7
ENST00000560411.5
ENST00000334660.10
F5GX29