FERMT2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	39 studies	31% ± 12%	Explore
fibroblast	39 studies	29% ± 11%	Explore
pericyte	34 studies	38% ± 14%	Explore
smooth muscle cell	30 studies	38% ± 14%	Explore
astrocyte	17 studies	37% ± 17%	Explore
myofibroblast cell	14 studies	33% ± 10%	Explore
capillary endothelial cell	13 studies	24% ± 7%	Explore
connective tissue cell	12 studies	35% ± 13%	Explore
mast cell	11 studies	26% ± 11%	Explore
oligodendrocyte	11 studies	30% ± 12%	Explore
endothelial cell of artery	10 studies	23% ± 6%	Explore
oligodendrocyte precursor cell	10 studies	27% ± 12%	Explore
adipocyte	10 studies	55% ± 13%	Explore
endothelial cell of vascular tree	10 studies	28% ± 11%	Explore
endothelial cell of lymphatic vessel	9 studies	24% ± 5%	Explore
type I pneumocyte	9 studies	32% ± 9%	Explore
vein endothelial cell	8 studies	25% ± 10%	Explore
GABAergic neuron	5 studies	27% ± 9%	Explore
neuron	5 studies	28% ± 14%	Explore
adventitial cell	5 studies	24% ± 7%	Explore
cardiac muscle cell	5 studies	25% ± 2%	Explore
podocyte	4 studies	36% ± 6%	Explore
glial cell	4 studies	24% ± 5%	Explore
glutamatergic neuron	4 studies	33% ± 8%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	31% ± 9%	Explore
glomerular endothelial cell	3 studies	22% ± 2%	Explore
abnormal cell	3 studies	33% ± 7%	Explore
Mueller cell	3 studies	24% ± 3%	Explore
rod bipolar cell	3 studies	25% ± 6%	Explore
basal cell	3 studies	30% ± 5%	Explore
hepatocyte	3 studies	47% ± 18%	Explore
muscle cell	3 studies	53% ± 23%	Explore
chondrocyte	3 studies	28% ± 2%	Explore
interneuron	3 studies	31% ± 13%	Explore
myoepithelial cell	3 studies	34% ± 19%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	11 studies	24% ± 11%	Explore
heart	4 studies	23% ± 3%	Explore
eye	4 studies	22% ± 9%	Explore
kidney	3 studies	19% ± 2%	Explore
lung	3 studies	25% ± 5%	Explore
uterus	3 studies	24% ± 4%	Explore
adipose	3 studies	37% ± 14%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	100%	6672.79	180 / 180	97%	17.60	419 / 430
liver	100%	4086.39	225 / 226	97%	17.45	395 / 406
breast	100%	10432.06	459 / 459	96%	21.81	1069 / 1118
kidney	99%	4472.71	88 / 89	96%	24.58	868 / 901
prostate	96%	7120.16	235 / 245	97%	21.56	488 / 502
thymus	99%	5517.69	648 / 653	93%	21.56	560 / 605
lung	100%	8924.27	576 / 578	90%	17.05	1044 / 1155
brain	82%	3335.60	2178 / 2642	100%	52.12	703 / 705
bladder	100%	13921.24	21 / 21	66%	10.68	332 / 504
uterus	99%	13854.61	168 / 170	62%	18.97	286 / 459
adrenal gland	72%	2009.66	185 / 258	86%	13.88	197 / 230
esophagus	78%	12119.51	1122 / 1445	77%	14.79	140 / 183
skin	62%	4895.91	1118 / 1809	92%	20.65	433 / 472
intestine	85%	12297.95	819 / 966	64%	9.52	338 / 527
stomach	71%	7092.09	255 / 359	73%	16.48	210 / 286
pancreas	17%	420.63	56 / 328	93%	20.77	166 / 178
adipose	100%	13151.91	1204 / 1204	0%	0	0 / 0
blood vessel	100%	19972.53	1335 / 1335	0%	0	0 / 0
heart	94%	5679.30	812 / 861	0%	0	0 / 0
muscle	94%	3518.54	756 / 803	0%	0	0 / 0
spleen	90%	3833.67	218 / 241	0%	0	0 / 0
eye	0%	0	0 / 0	65%	6.52	52 / 80
tonsil	0%	0	0 / 0	42%	3.74	19 / 45
lymph node	0%	0	0 / 0	24%	1.76	7 / 29
peripheral blood	0%	3.00	1 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0034334	Biological process	adherens junction maintenance
GO_0043547	Biological process	positive regulation of GTPase activity
GO_0051496	Biological process	positive regulation of stress fiber assembly
GO_0007160	Biological process	cell-matrix adhesion
GO_0043116	Biological process	negative regulation of vascular permeability
GO_0022604	Biological process	regulation of cell morphogenesis
GO_0060173	Biological process	limb development
GO_0045599	Biological process	negative regulation of fat cell differentiation
GO_0035505	Biological process	positive regulation of myosin light chain kinase activity
GO_1902414	Biological process	protein localization to cell junction
GO_0007155	Biological process	cell adhesion
GO_1902462	Biological process	positive regulation of mesenchymal stem cell proliferation
GO_0045669	Biological process	positive regulation of osteoblast differentiation
GO_1903691	Biological process	positive regulation of wound healing, spreading of epidermal cells
GO_0007229	Biological process	integrin-mediated signaling pathway
GO_0034446	Biological process	substrate adhesion-dependent cell spreading
GO_0030335	Biological process	positive regulation of cell migration
GO_0051894	Biological process	positive regulation of focal adhesion assembly
GO_0048041	Biological process	focal adhesion assembly
GO_0010718	Biological process	positive regulation of epithelial to mesenchymal transition
GO_1900026	Biological process	positive regulation of substrate adhesion-dependent cell spreading
GO_0051897	Biological process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0008360	Biological process	regulation of cell shape
GO_0016055	Biological process	Wnt signaling pathway
GO_0033622	Biological process	integrin activation
GO_0070374	Biological process	positive regulation of ERK1 and ERK2 cascade
GO_0007179	Biological process	transforming growth factor beta receptor signaling pathway
GO_0033625	Biological process	positive regulation of integrin activation
GO_0072657	Biological process	protein localization to membrane
GO_1900182	Biological process	positive regulation of protein localization to nucleus
GO_0005886	Cellular component	plasma membrane
GO_0009898	Cellular component	cytoplasmic side of plasma membrane
GO_0005654	Cellular component	nucleoplasm
GO_0005925	Cellular component	focal adhesion
GO_0009986	Cellular component	cell surface
GO_0001725	Cellular component	stress fiber
GO_0031674	Cellular component	I band
GO_0031258	Cellular component	lamellipodium membrane
GO_0005829	Cellular component	cytosol
GO_0005912	Cellular component	adherens junction
GO_0005938	Cellular component	cell cortex
GO_0005737	Cellular component	cytoplasm
GO_0030054	Cellular component	cell junction
GO_0005634	Cellular component	nucleus
GO_0005547	Molecular function	phosphatidylinositol-3,4,5-trisphosphate binding
GO_0019901	Molecular function	protein kinase binding
GO_0051015	Molecular function	actin filament binding
GO_0046332	Molecular function	SMAD binding
GO_0005178	Molecular function	integrin binding
GO_0034713	Molecular function	type I transforming growth factor beta receptor binding
GO_0005515	Molecular function	protein binding
GO_0003779	Molecular function	actin binding

IV. Literature review

[source]

Gene name	FERMT2
Protein name	FERM domain containing kindlin 2 Fermitin family homolog 2 (Kindlin-2) (Mitogen-inducible gene 2 protein) (MIG-2) (Pleckstrin homology domain-containing family C member 1) (PH domain-containing family C member 1)
Synonyms	KIND2 PLEKHC1 MIG2
Description	FUNCTION: Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. .
Accessions	ENST00000554152.5 ENST00000554712.5 ENST00000557562.1 Q96AC1 ENST00000395631.6 [Q96AC1-1] ENST00000343279.8 [Q96AC1-3] G3V5R2 H0YJ34 ENST00000399304.7 [Q96AC1-2] ENST00000554288.1 G3V281 G3V3J0 H0YJB6 ENST00000341590.8 [Q96AC1-1] ENST00000555692.5 G3V379 A0A0U1RRM8 ENST00000553373.5 [Q96AC1-3] ENST00000553663.5 ENST00000635305.1

FERMT2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review