PTPN12 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006470Biological processprotein dephosphorylation
GO_0071364Biological processcellular response to epidermal growth factor stimulus
GO_0035335Biological processpeptidyl-tyrosine dephosphorylation
GO_0042246Biological processtissue regeneration
GO_0042058Biological processregulation of epidermal growth factor receptor signaling pathway
GO_1901185Biological processnegative regulation of ERBB signaling pathway
GO_2000587Biological processnegative regulation of platelet-derived growth factor receptor-beta signaling pathway
GO_0002102Cellular componentpodosome
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0005925Cellular componentfocal adhesion
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0042995Cellular componentcell projection
GO_0004726Molecular functionnon-membrane spanning protein tyrosine phosphatase activity
GO_0004721Molecular functionphosphoprotein phosphatase activity
GO_0005515Molecular functionprotein binding
GO_0017124Molecular functionSH3 domain binding
GO_0004725Molecular functionprotein tyrosine phosphatase activity

IV. Literature review

[source]
Gene namePTPN12
Protein nameTyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1)
protein-tyrosine-phosphatase (EC 3.1.3.48)
Protein tyrosine phosphatase non-receptor type 12
Synonyms
DescriptionFUNCTION: Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades . Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 . Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' . .

AccessionsENST00000435495.6 [Q05209-2]
ENST00000418110.5
ENST00000440186.5
ENST00000433369.6
Q05209
ENST00000407343.3
C9JJC1
H0YB59
ENST00000447995.2
ENST00000415482.6 [Q05209-3]
H3BM04
H0YC15
ENST00000523952.5
C9JYA4
F8WB51
ENST00000248594.11 [Q05209-1]
C9J1X8
ENST00000522115.6