Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 45 studies | 37% ± 16% | |
natural killer cell | 28 studies | 26% ± 9% | |
macrophage | 22 studies | 32% ± 17% | |
pericyte | 21 studies | 30% ± 11% | |
fibroblast | 17 studies | 29% ± 11% | |
CD16-positive, CD56-dim natural killer cell, human | 14 studies | 29% ± 11% | |
endothelial cell of lymphatic vessel | 12 studies | 32% ± 14% | |
classical monocyte | 12 studies | 29% ± 11% | |
capillary endothelial cell | 12 studies | 29% ± 9% | |
endothelial cell of artery | 12 studies | 29% ± 9% | |
astrocyte | 12 studies | 28% ± 12% | |
endothelial cell of vascular tree | 12 studies | 30% ± 16% | |
monocyte | 11 studies | 36% ± 18% | |
smooth muscle cell | 11 studies | 24% ± 8% | |
oligodendrocyte precursor cell | 11 studies | 31% ± 15% | |
microglial cell | 11 studies | 28% ± 11% | |
type I pneumocyte | 9 studies | 33% ± 14% | |
CD16-negative, CD56-bright natural killer cell, human | 9 studies | 24% ± 5% | |
glutamatergic neuron | 9 studies | 39% ± 24% | |
myeloid cell | 9 studies | 34% ± 12% | |
adipocyte | 9 studies | 25% ± 8% | |
vein endothelial cell | 9 studies | 34% ± 15% | |
oligodendrocyte | 9 studies | 27% ± 11% | |
alveolar macrophage | 8 studies | 39% ± 18% | |
GABAergic neuron | 8 studies | 40% ± 16% | |
basal cell | 8 studies | 26% ± 12% | |
platelet | 7 studies | 27% ± 10% | |
epithelial cell | 7 studies | 37% ± 15% | |
non-classical monocyte | 6 studies | 26% ± 8% | |
neuron | 6 studies | 37% ± 14% | |
interneuron | 6 studies | 39% ± 20% | |
dendritic cell | 6 studies | 30% ± 8% | |
mononuclear phagocyte | 6 studies | 25% ± 13% | |
type II pneumocyte | 6 studies | 39% ± 11% | |
neutrophil | 5 studies | 21% ± 7% | |
conventional dendritic cell | 5 studies | 22% ± 11% | |
ciliated cell | 5 studies | 27% ± 11% | |
lymphocyte | 5 studies | 23% ± 4% | |
club cell | 5 studies | 31% ± 10% | |
mature NK T cell | 4 studies | 25% ± 9% | |
myofibroblast cell | 4 studies | 26% ± 9% | |
megakaryocyte | 4 studies | 37% ± 15% | |
mesothelial cell | 4 studies | 25% ± 6% | |
Mueller cell | 4 studies | 21% ± 2% | |
abnormal cell | 4 studies | 25% ± 8% | |
goblet cell | 4 studies | 32% ± 24% | |
hematopoietic precursor cell | 3 studies | 30% ± 15% | |
glomerular endothelial cell | 3 studies | 26% ± 3% | |
GABAergic interneuron | 3 studies | 24% ± 11% | |
glial cell | 3 studies | 32% ± 2% | |
granule cell | 3 studies | 21% ± 2% | |
squamous epithelial cell | 3 studies | 33% ± 20% | |
muscle cell | 3 studies | 23% ± 10% | |
connective tissue cell | 3 studies | 27% ± 8% | |
hematopoietic stem cell | 3 studies | 22% ± 4% | |
Schwann cell | 3 studies | 41% ± 22% | |
secretory cell | 3 studies | 21% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 6173.71 | 1445 / 1445 | 100% | 81.75 | 183 / 183 |
lung | 100% | 10742.97 | 578 / 578 | 100% | 70.35 | 1155 / 1155 |
ovary | 100% | 5359.63 | 180 / 180 | 100% | 43.86 | 429 / 430 |
breast | 100% | 8414.18 | 459 / 459 | 100% | 72.08 | 1114 / 1118 |
brain | 99% | 2796.14 | 2624 / 2642 | 100% | 49.96 | 705 / 705 |
uterus | 100% | 6311.78 | 170 / 170 | 99% | 55.60 | 455 / 459 |
thymus | 100% | 5487.17 | 653 / 653 | 99% | 46.51 | 598 / 605 |
bladder | 100% | 6260.57 | 21 / 21 | 99% | 48.95 | 497 / 504 |
intestine | 100% | 6229.67 | 966 / 966 | 98% | 51.02 | 519 / 527 |
stomach | 99% | 3651.16 | 355 / 359 | 98% | 51.64 | 281 / 286 |
skin | 100% | 6090.27 | 1809 / 1809 | 96% | 71.54 | 453 / 472 |
kidney | 100% | 3953.55 | 89 / 89 | 96% | 55.25 | 863 / 901 |
prostate | 99% | 4595.09 | 243 / 245 | 96% | 27.98 | 483 / 502 |
adrenal gland | 100% | 3778.98 | 258 / 258 | 94% | 28.18 | 217 / 230 |
pancreas | 85% | 1776.35 | 280 / 328 | 99% | 60.84 | 176 / 178 |
liver | 85% | 1741.22 | 191 / 226 | 83% | 23.41 | 338 / 406 |
adipose | 100% | 9736.03 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 7484.75 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 7751.39 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 53.01 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 14.37 | 1 / 1 |
heart | 100% | 3738.26 | 859 / 861 | 0% | 0 | 0 / 0 |
muscle | 95% | 2219.15 | 762 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 94% | 4086.17 | 869 / 929 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 86% | 27.38 | 25 / 29 |
eye | 0% | 0 | 0 / 0 | 70% | 19.47 | 56 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006470 | Biological process | protein dephosphorylation |
GO_0071364 | Biological process | cellular response to epidermal growth factor stimulus |
GO_0035335 | Biological process | peptidyl-tyrosine dephosphorylation |
GO_0042246 | Biological process | tissue regeneration |
GO_0042058 | Biological process | regulation of epidermal growth factor receptor signaling pathway |
GO_1901185 | Biological process | negative regulation of ERBB signaling pathway |
GO_2000587 | Biological process | negative regulation of platelet-derived growth factor receptor-beta signaling pathway |
GO_0002102 | Cellular component | podosome |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0005925 | Cellular component | focal adhesion |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0042995 | Cellular component | cell projection |
GO_0004726 | Molecular function | non-membrane spanning protein tyrosine phosphatase activity |
GO_0004721 | Molecular function | phosphoprotein phosphatase activity |
GO_0005515 | Molecular function | protein binding |
GO_0017124 | Molecular function | SH3 domain binding |
GO_0004725 | Molecular function | protein tyrosine phosphatase activity |
Gene name | PTPN12 |
Protein name | Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1) protein-tyrosine-phosphatase (EC 3.1.3.48) Protein tyrosine phosphatase non-receptor type 12 |
Synonyms | |
Description | FUNCTION: Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades . Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 . Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' . . |
Accessions | ENST00000435495.6 [Q05209-2] ENST00000418110.5 ENST00000440186.5 ENST00000433369.6 Q05209 ENST00000407343.3 C9JJC1 H0YB59 ENST00000447995.2 ENST00000415482.6 [Q05209-3] H3BM04 H0YC15 ENST00000523952.5 C9JYA4 F8WB51 ENST00000248594.11 [Q05209-1] C9J1X8 ENST00000522115.6 |