PTPRA | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	31 studies	32% ± 15%	Explore
fibroblast	25 studies	27% ± 10%	Explore
pericyte	24 studies	27% ± 12%	Explore
natural killer cell	23 studies	26% ± 9%	Explore
astrocyte	20 studies	46% ± 18%	Explore
smooth muscle cell	17 studies	23% ± 8%	Explore
ciliated cell	15 studies	28% ± 13%	Explore
oligodendrocyte	15 studies	40% ± 16%	Explore
oligodendrocyte precursor cell	15 studies	39% ± 19%	Explore
glutamatergic neuron	13 studies	55% ± 25%	Explore
macrophage	12 studies	30% ± 12%	Explore
microglial cell	12 studies	35% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	11 studies	29% ± 9%	Explore
GABAergic neuron	11 studies	50% ± 24%	Explore
B cell	10 studies	23% ± 5%	Explore
endothelial cell of lymphatic vessel	10 studies	26% ± 10%	Explore
T cell	9 studies	24% ± 7%	Explore
CD4-positive, alpha-beta T cell	9 studies	21% ± 5%	Explore
CD8-positive, alpha-beta T cell	9 studies	23% ± 6%	Explore
neuron	9 studies	46% ± 21%	Explore
epithelial cell	9 studies	35% ± 17%	Explore
adipocyte	9 studies	32% ± 9%	Explore
gamma-delta T cell	9 studies	22% ± 5%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	21% ± 3%	Explore
basal cell	8 studies	32% ± 17%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	23% ± 6%	Explore
regulatory T cell	8 studies	18% ± 2%	Explore
mature NK T cell	7 studies	25% ± 7%	Explore
retinal ganglion cell	7 studies	38% ± 14%	Explore
myeloid cell	7 studies	30% ± 6%	Explore
mast cell	7 studies	23% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	26% ± 4%	Explore
capillary endothelial cell	6 studies	21% ± 6%	Explore
interneuron	6 studies	61% ± 22%	Explore
club cell	6 studies	27% ± 8%	Explore
amacrine cell	6 studies	33% ± 10%	Explore
retina horizontal cell	6 studies	31% ± 8%	Explore
retinal cone cell	6 studies	28% ± 10%	Explore
dendritic cell	6 studies	25% ± 8%	Explore
Mueller cell	6 studies	32% ± 6%	Explore
type I pneumocyte	6 studies	26% ± 7%	Explore
non-classical monocyte	5 studies	23% ± 9%	Explore
abnormal cell	5 studies	30% ± 16%	Explore
retinal bipolar neuron	5 studies	28% ± 7%	Explore
retinal rod cell	5 studies	26% ± 4%	Explore
connective tissue cell	5 studies	26% ± 6%	Explore
monocyte	5 studies	31% ± 6%	Explore
myofibroblast cell	5 studies	26% ± 8%	Explore
type II pneumocyte	5 studies	22% ± 6%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	18% ± 1%	Explore
secretory cell	4 studies	27% ± 16%	Explore
leukocyte	4 studies	30% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	23% ± 3%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	4 studies	23% ± 4%	Explore
granule cell	4 studies	44% ± 9%	Explore
retinal pigment epithelial cell	4 studies	32% ± 13%	Explore
cardiac muscle cell	4 studies	27% ± 1%	Explore
mucosal invariant T cell	4 studies	20% ± 6%	Explore
lymphocyte	4 studies	41% ± 9%	Explore
OFF-bipolar cell	4 studies	30% ± 5%	Explore
ON-bipolar cell	4 studies	28% ± 5%	Explore
muscle cell	4 studies	29% ± 16%	Explore
goblet cell	4 studies	32% ± 22%	Explore
naive B cell	3 studies	16% ± 1%	Explore
hematopoietic precursor cell	3 studies	27% ± 8%	Explore
glomerular endothelial cell	3 studies	21% ± 1%	Explore
neural crest cell	3 studies	18% ± 1%	Explore
GABAergic interneuron	3 studies	52% ± 7%	Explore
glial cell	3 studies	39% ± 9%	Explore
progenitor cell	3 studies	35% ± 6%	Explore
plasma cell	3 studies	29% ± 7%	Explore
endothelial cell of artery	3 studies	16% ± 1%	Explore
mononuclear phagocyte	3 studies	24% ± 4%	Explore
vein endothelial cell	3 studies	32% ± 19%	Explore
GABAergic amacrine cell	3 studies	39% ± 11%	Explore
glycinergic amacrine cell	3 studies	30% ± 3%	Explore
rod bipolar cell	3 studies	40% ± 1%	Explore
innate lymphoid cell	3 studies	18% ± 1%	Explore
endothelial cell of vascular tree	3 studies	35% ± 15%	Explore
ependymal cell	3 studies	57% ± 14%	Explore
enteroendocrine cell	3 studies	26% ± 8%	Explore
adventitial cell	3 studies	21% ± 1%	Explore
alveolar macrophage	3 studies	37% ± 9%	Explore
respiratory goblet cell	3 studies	31% ± 9%	Explore
Schwann cell	3 studies	31% ± 16%	Explore
transit amplifying cell	3 studies	37% ± 25%	Explore
plasmacytoid dendritic cell	3 studies	21% ± 4%	Explore
mural cell	3 studies	43% ± 15%	Explore
mucus secreting cell	3 studies	27% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	19 studies	45% ± 22%	Explore
lung	11 studies	26% ± 11%	Explore
eye	8 studies	32% ± 10%	Explore
peripheral blood	6 studies	25% ± 7%	Explore
heart	5 studies	25% ± 6%	Explore
intestine	4 studies	23% ± 6%	Explore
adipose	4 studies	35% ± 10%	Explore
liver	4 studies	30% ± 17%	Explore
kidney	3 studies	19% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	10677.82	2642 / 2642	100%	196.22	705 / 705
esophagus	100%	4600.68	1445 / 1445	100%	64.26	183 / 183
ovary	100%	5834.24	180 / 180	100%	81.53	430 / 430
prostate	100%	4710.47	245 / 245	100%	78.33	502 / 502
stomach	100%	3220.36	359 / 359	100%	66.28	286 / 286
breast	100%	6406.75	459 / 459	100%	93.56	1117 / 1118
thymus	100%	6297.09	653 / 653	100%	100.56	604 / 605
skin	100%	6170.04	1809 / 1809	100%	112.21	471 / 472
kidney	100%	4277.25	89 / 89	100%	67.98	899 / 901
bladder	100%	4906.00	21 / 21	100%	67.19	502 / 504
lung	100%	5117.95	577 / 578	100%	65.49	1151 / 1155
intestine	100%	4800.70	966 / 966	99%	63.74	524 / 527
uterus	100%	6387.38	170 / 170	99%	67.48	455 / 459
adrenal gland	100%	3728.17	258 / 258	98%	94.72	226 / 230
pancreas	94%	1882.73	309 / 328	98%	65.50	175 / 178
liver	85%	1320.84	191 / 226	87%	28.82	352 / 406
adipose	100%	6675.25	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	47.26	29 / 29
spleen	100%	4157.26	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	55.11	45 / 45
ureter	0%	0	0 / 0	100%	25.06	1 / 1
blood vessel	100%	5524.92	1334 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	99%	70.74	79 / 80
heart	95%	2302.65	819 / 861	0%	0	0 / 0
peripheral blood	91%	2980.07	850 / 929	0%	0	0 / 0
muscle	78%	1272.28	625 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007229	Biological process	integrin-mediated signaling pathway
GO_0008286	Biological process	insulin receptor signaling pathway
GO_0006470	Biological process	protein dephosphorylation
GO_0050804	Biological process	modulation of chemical synaptic transmission
GO_0051893	Biological process	regulation of focal adhesion assembly
GO_0097060	Cellular component	synaptic membrane
GO_0070062	Cellular component	extracellular exosome
GO_0043235	Cellular component	receptor complex
GO_0098685	Cellular component	Schaffer collateral - CA1 synapse
GO_0005886	Cellular component	plasma membrane
GO_0005925	Cellular component	focal adhesion
GO_0016020	Cellular component	membrane
GO_0005001	Molecular function	transmembrane receptor protein tyrosine phosphatase activity
GO_0005515	Molecular function	protein binding
GO_0004725	Molecular function	protein tyrosine phosphatase activity

IV. Literature review

[source]

Gene name	PTPRA
Protein name	Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48) Protein tyrosine phosphatase receptor type A Receptor-type tyrosine-protein phosphatase alpha (EC 3.1.3.48)
Synonyms	PTPA PTPRL2
Description	FUNCTION: Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation (By similarity). Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 (By similarity). .
Accessions	Q5JWG3 ENST00000430705.5 Q5JWG0 ENST00000356147.3 [P18433-6] ENST00000216877.10 [P18433-6] P18433 A0A1S5UZ22 Q5JWG2 ENST00000431048.5 ENST00000399903.7 [P18433-5] ENST00000455631.5 ENST00000318266.9 [P18433-6]

PTPRA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review