CAPN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000310Biological processregulation of NMDA receptor activity
GO_0060056Biological processmammary gland involution
GO_0097264Biological processself proteolysis
GO_0006508Biological processproteolysis
GO_0050790Biological processregulation of catalytic activity
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0016241Biological processregulation of macroautophagy
GO_0032801Biological processreceptor catabolic process
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0005764Cellular componentlysosome
GO_0070062Cellular componentextracellular exosome
GO_0005925Cellular componentfocal adhesion
GO_0001533Cellular componentcornified envelope
GO_1904813Cellular componentficolin-1-rich granule lumen
GO_0005829Cellular componentcytosol
GO_0110158Cellular componentcalpain complex
GO_0005737Cellular componentcytoplasm
GO_0008233Molecular functionpeptidase activity
GO_0004198Molecular functioncalcium-dependent cysteine-type endopeptidase activity
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCAPN1
Protein nameCalpain 1
Calpain-1 catalytic subunit (EC 3.4.22.52) (Calcium-activated neutral proteinase 1) (CANP 1) (Calpain mu-type) (Calpain-1 large subunit) (Cell proliferation-inducing gene 30 protein) (Micromolar-calpain) (muCANP)
SynonymsCANPL1
PIG30
DescriptionFUNCTION: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction . Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-387' and 'His-409' . Cleaves and activates caspase-7 (CASP7) . .

AccessionsENST00000526966.5
ENST00000533909.5
ENST00000526954.5
E9PLC9
ENST00000524773.5
ENST00000533129.5
E9PJA6
ENST00000533820.5
ENST00000534373.5
E9PSA6
ENST00000527739.5
E9PMC6
ENST00000532285.1
E9PQB3
ENST00000527323.5
ENST00000526468.1
E9PRM1
E9PIA9
ENST00000279247.11
ENST00000529133.5
P07384
E9PLX0
ENST00000527699.5
ENST00000531068.5
E9PJJ3
ENST00000528396.5
E9PL37