Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 38 studies | 49% ± 23% | |
pericyte | 35 studies | 45% ± 19% | |
smooth muscle cell | 27 studies | 42% ± 17% | |
fibroblast | 20 studies | 44% ± 20% | |
astrocyte | 19 studies | 61% ± 18% | |
oligodendrocyte | 17 studies | 71% ± 21% | |
oligodendrocyte precursor cell | 17 studies | 59% ± 21% | |
microglial cell | 15 studies | 47% ± 16% | |
glutamatergic neuron | 12 studies | 74% ± 20% | |
capillary endothelial cell | 12 studies | 30% ± 17% | |
basal cell | 11 studies | 44% ± 26% | |
ciliated cell | 11 studies | 36% ± 15% | |
GABAergic neuron | 11 studies | 63% ± 22% | |
endothelial cell of artery | 11 studies | 33% ± 20% | |
epithelial cell | 11 studies | 45% ± 23% | |
endothelial cell of lymphatic vessel | 10 studies | 46% ± 20% | |
macrophage | 10 studies | 36% ± 19% | |
adipocyte | 9 studies | 45% ± 15% | |
neuron | 8 studies | 58% ± 25% | |
mesothelial cell | 8 studies | 46% ± 14% | |
vein endothelial cell | 8 studies | 44% ± 27% | |
club cell | 7 studies | 44% ± 22% | |
mast cell | 7 studies | 30% ± 10% | |
type I pneumocyte | 7 studies | 44% ± 20% | |
interneuron | 6 studies | 72% ± 14% | |
retinal ganglion cell | 6 studies | 52% ± 29% | |
retina horizontal cell | 6 studies | 48% ± 25% | |
retinal cone cell | 6 studies | 46% ± 20% | |
myofibroblast cell | 6 studies | 40% ± 22% | |
type II pneumocyte | 6 studies | 46% ± 17% | |
amacrine cell | 5 studies | 52% ± 21% | |
cardiac muscle cell | 5 studies | 47% ± 12% | |
dendritic cell | 5 studies | 32% ± 12% | |
Mueller cell | 5 studies | 55% ± 25% | |
respiratory goblet cell | 5 studies | 49% ± 23% | |
endothelial cell of vascular tree | 5 studies | 49% ± 23% | |
connective tissue cell | 5 studies | 44% ± 18% | |
secretory cell | 4 studies | 31% ± 10% | |
cholangiocyte | 4 studies | 55% ± 22% | |
abnormal cell | 4 studies | 37% ± 24% | |
glial cell | 4 studies | 54% ± 9% | |
granule cell | 4 studies | 71% ± 14% | |
OFF-bipolar cell | 4 studies | 43% ± 21% | |
ON-bipolar cell | 4 studies | 43% ± 22% | |
retinal rod cell | 4 studies | 58% ± 10% | |
muscle cell | 4 studies | 45% ± 19% | |
goblet cell | 4 studies | 40% ± 30% | |
ionocyte | 3 studies | 29% ± 3% | |
endothelial cell of sinusoid | 3 studies | 38% ± 11% | |
hepatic stellate cell | 3 studies | 49% ± 24% | |
differentiation-committed oligodendrocyte precursor | 3 studies | 75% ± 4% | |
GABAergic interneuron | 3 studies | 68% ± 3% | |
progenitor cell | 3 studies | 52% ± 9% | |
endocardial cell | 3 studies | 46% ± 17% | |
retinal bipolar neuron | 3 studies | 45% ± 20% | |
GABAergic amacrine cell | 3 studies | 61% ± 13% | |
glycinergic amacrine cell | 3 studies | 53% ± 10% | |
rod bipolar cell | 3 studies | 43% ± 20% | |
myeloid cell | 3 studies | 29% ± 8% | |
hepatocyte | 3 studies | 56% ± 17% | |
retinal pigment epithelial cell | 3 studies | 50% ± 30% | |
neural progenitor cell | 3 studies | 71% ± 11% | |
ependymal cell | 3 studies | 70% ± 6% | |
B cell | 3 studies | 28% ± 4% | |
chondrocyte | 3 studies | 44% ± 21% | |
monocyte | 3 studies | 23% ± 4% | |
Schwann cell | 3 studies | 55% ± 15% | |
transit amplifying cell | 3 studies | 43% ± 36% | |
brush cell | 3 studies | 26% ± 7% | |
kidney loop of Henle epithelial cell | 3 studies | 42% ± 20% | |
mucus secreting cell | 3 studies | 55% ± 12% | |
enteroendocrine cell | 3 studies | 25% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 4875.24 | 1445 / 1445 | 100% | 35.31 | 183 / 183 |
lung | 100% | 6291.23 | 578 / 578 | 100% | 34.32 | 1155 / 1155 |
breast | 100% | 7085.20 | 459 / 459 | 100% | 41.85 | 1117 / 1118 |
brain | 100% | 8264.64 | 2642 / 2642 | 100% | 39.49 | 704 / 705 |
ovary | 100% | 5251.59 | 180 / 180 | 100% | 30.52 | 429 / 430 |
intestine | 100% | 5769.53 | 966 / 966 | 100% | 28.42 | 525 / 527 |
prostate | 100% | 5813.87 | 245 / 245 | 100% | 28.67 | 500 / 502 |
stomach | 100% | 4580.51 | 359 / 359 | 99% | 29.80 | 284 / 286 |
bladder | 100% | 6265.10 | 21 / 21 | 99% | 33.42 | 500 / 504 |
kidney | 100% | 5088.64 | 89 / 89 | 99% | 27.50 | 889 / 901 |
uterus | 100% | 6391.32 | 170 / 170 | 98% | 27.58 | 452 / 459 |
skin | 100% | 4761.43 | 1808 / 1809 | 98% | 33.69 | 464 / 472 |
pancreas | 99% | 2934.77 | 324 / 328 | 99% | 27.25 | 177 / 178 |
thymus | 100% | 6337.29 | 653 / 653 | 97% | 25.99 | 584 / 605 |
adrenal gland | 100% | 7275.59 | 258 / 258 | 95% | 20.66 | 219 / 230 |
liver | 97% | 1876.95 | 220 / 226 | 94% | 16.49 | 383 / 406 |
adipose | 100% | 7392.23 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 11217.47 | 1335 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 4015.58 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 3188.41 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 27.73 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 36.69 | 1 / 1 |
heart | 99% | 3465.57 | 854 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 96% | 33.00 | 77 / 80 |
lymph node | 0% | 0 | 0 / 0 | 66% | 10.82 | 19 / 29 |
peripheral blood | 13% | 327.18 | 119 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0120041 | Biological process | positive regulation of macrophage proliferation |
GO_0030010 | Biological process | establishment of cell polarity |
GO_0048870 | Biological process | cell motility |
GO_0001525 | Biological process | angiogenesis |
GO_0048013 | Biological process | ephrin receptor signaling pathway |
GO_0045667 | Biological process | regulation of osteoblast differentiation |
GO_0051493 | Biological process | regulation of cytoskeleton organization |
GO_0010763 | Biological process | positive regulation of fibroblast migration |
GO_0060396 | Biological process | growth hormone receptor signaling pathway |
GO_0010594 | Biological process | regulation of endothelial cell migration |
GO_2000811 | Biological process | negative regulation of anoikis |
GO_0001932 | Biological process | regulation of protein phosphorylation |
GO_0001934 | Biological process | positive regulation of protein phosphorylation |
GO_0001890 | Biological process | placenta development |
GO_0003007 | Biological process | heart morphogenesis |
GO_0045860 | Biological process | positive regulation of protein kinase activity |
GO_0010759 | Biological process | positive regulation of macrophage chemotaxis |
GO_0022408 | Biological process | negative regulation of cell-cell adhesion |
GO_0018108 | Biological process | peptidyl-tyrosine phosphorylation |
GO_0007229 | Biological process | integrin-mediated signaling pathway |
GO_2000060 | Biological process | positive regulation of ubiquitin-dependent protein catabolic process |
GO_0043066 | Biological process | negative regulation of apoptotic process |
GO_0030335 | Biological process | positive regulation of cell migration |
GO_0043087 | Biological process | regulation of GTPase activity |
GO_1900024 | Biological process | regulation of substrate adhesion-dependent cell spreading |
GO_0033628 | Biological process | regulation of cell adhesion mediated by integrin |
GO_0035995 | Biological process | detection of muscle stretch |
GO_0007172 | Biological process | signal complex assembly |
GO_0051893 | Biological process | regulation of focal adhesion assembly |
GO_0090303 | Biological process | positive regulation of wound healing |
GO_0010718 | Biological process | positive regulation of epithelial to mesenchymal transition |
GO_0007173 | Biological process | epidermal growth factor receptor signaling pathway |
GO_0008284 | Biological process | positive regulation of cell population proliferation |
GO_0038007 | Biological process | netrin-activated signaling pathway |
GO_0008360 | Biological process | regulation of cell shape |
GO_0048010 | Biological process | vascular endothelial growth factor receptor signaling pathway |
GO_0038096 | Biological process | Fc-gamma receptor signaling pathway involved in phagocytosis |
GO_0051897 | Biological process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
GO_0006468 | Biological process | protein phosphorylation |
GO_0010632 | Biological process | regulation of epithelial cell migration |
GO_0046777 | Biological process | protein autophosphorylation |
GO_0030155 | Biological process | regulation of cell adhesion |
GO_0007179 | Biological process | transforming growth factor beta receptor signaling pathway |
GO_0016477 | Biological process | cell migration |
GO_0042127 | Biological process | regulation of cell population proliferation |
GO_0010634 | Biological process | positive regulation of epithelial cell migration |
GO_0007411 | Biological process | axon guidance |
GO_0005856 | Cellular component | cytoskeleton |
GO_0005886 | Cellular component | plasma membrane |
GO_0043197 | Cellular component | dendritic spine |
GO_0048471 | Cellular component | perinuclear region of cytoplasm |
GO_0005813 | Cellular component | centrosome |
GO_0005925 | Cellular component | focal adhesion |
GO_0001725 | Cellular component | stress fiber |
GO_0005829 | Cellular component | cytosol |
GO_0005938 | Cellular component | cell cortex |
GO_0005737 | Cellular component | cytoplasm |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0036064 | Cellular component | ciliary basal body |
GO_0005634 | Cellular component | nucleus |
GO_0004715 | Molecular function | non-membrane spanning protein tyrosine kinase activity |
GO_0140677 | Molecular function | molecular function activator activity |
GO_0008432 | Molecular function | JUN kinase binding |
GO_0019903 | Molecular function | protein phosphatase binding |
GO_0004713 | Molecular function | protein tyrosine kinase activity |
GO_0019901 | Molecular function | protein kinase binding |
GO_0003779 | Molecular function | actin binding |
GO_0005178 | Molecular function | integrin binding |
GO_0042169 | Molecular function | SH2 domain binding |
GO_0004725 | Molecular function | protein tyrosine phosphatase activity |
GO_0005524 | Molecular function | ATP binding |
GO_0005515 | Molecular function | protein binding |
Gene name | PTK2 |
Protein name | Protein tyrosine kinase 2 Protein tyrosine kinase 2 (cDNA FLJ57218, highly similar to Focal adhesion kinase 1) Focal adhesion kinase 1 (EC 2.7.10.2) (Protein-tyrosine kinase 2) (pp125FAK) non-specific protein-tyrosine kinase (EC 2.7.10.2) PTK2 protein Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK) |
Synonyms | FAK FAK1 |
Description | FUNCTION: Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Phosphorylates NEDD9 following integrin stimulation . Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. .; FUNCTION: [Isoform 6]: Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. . |
Accessions | A0A8Q3WLM4 ENST00000522950.1 ENST00000524040.5 ENST00000430260.6 ENST00000521986.5 ENST00000521907.5 E5RH48 H0YAS0 E5RII9 ENST00000524257.5 E5RIR5 B4DWJ1 ENST00000519881.5 Q05397 ENST00000520045.5 ENST00000519465.5 E5RH01 ENST00000521395.5 ENST00000523670.5 H0YBZ1 E5RJQ2 E5RI72 ENST00000696786.1 E9PEI4 ENST00000519024.5 ENST00000521791.5 E5RJN1 E5RG80 E5RG86 ENST00000522424.5 ENST00000523388.5 E5RH08 E5RHK7 E5RJI4 ENST00000520475.5 ENST00000524202.5 E5RI03 ENST00000517887.5 ENST00000523539.5 ENST00000517712.5 H0YB16 E5RI29 ENST00000521059.5 [Q05397-1] H0YB99 ENST00000521562.5 ENST00000524357.5 E5RHD8 ENST00000523679.1 ENST00000519419.5 I6L996 ENST00000521029.5 H0YBP1 ENST00000395218.3 [Q05397-7] E5RGP1 ENST00000520151.5 ENST00000520828.5 E5RG54 ENST00000340930.7 [Q05397-5] ENST00000522684.5 [Q05397-1] ENST00000519993.5 E5RGA6 ENST00000517453.5 ENST00000521332.5 ENST00000523803.5 A0A1D5RMT1 E5RFW9 ENST00000523067.5 H0YB33 ENST00000519654.5 ENST00000523435.1 ENST00000521250.5 E5RIK4 ENST00000520892.5 E7ESA6 E5RG66 E5RJP0 ENST00000521981.5 |