PTK2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0120041Biological processpositive regulation of macrophage proliferation
GO_0030010Biological processestablishment of cell polarity
GO_0048870Biological processcell motility
GO_0001525Biological processangiogenesis
GO_0048013Biological processephrin receptor signaling pathway
GO_0045667Biological processregulation of osteoblast differentiation
GO_0051493Biological processregulation of cytoskeleton organization
GO_0010763Biological processpositive regulation of fibroblast migration
GO_0060396Biological processgrowth hormone receptor signaling pathway
GO_0010594Biological processregulation of endothelial cell migration
GO_2000811Biological processnegative regulation of anoikis
GO_0001932Biological processregulation of protein phosphorylation
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0001890Biological processplacenta development
GO_0003007Biological processheart morphogenesis
GO_0045860Biological processpositive regulation of protein kinase activity
GO_0010759Biological processpositive regulation of macrophage chemotaxis
GO_0022408Biological processnegative regulation of cell-cell adhesion
GO_0018108Biological processpeptidyl-tyrosine phosphorylation
GO_0007229Biological processintegrin-mediated signaling pathway
GO_2000060Biological processpositive regulation of ubiquitin-dependent protein catabolic process
GO_0043066Biological processnegative regulation of apoptotic process
GO_0030335Biological processpositive regulation of cell migration
GO_0043087Biological processregulation of GTPase activity
GO_1900024Biological processregulation of substrate adhesion-dependent cell spreading
GO_0033628Biological processregulation of cell adhesion mediated by integrin
GO_0035995Biological processdetection of muscle stretch
GO_0007172Biological processsignal complex assembly
GO_0051893Biological processregulation of focal adhesion assembly
GO_0090303Biological processpositive regulation of wound healing
GO_0010718Biological processpositive regulation of epithelial to mesenchymal transition
GO_0007173Biological processepidermal growth factor receptor signaling pathway
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0038007Biological processnetrin-activated signaling pathway
GO_0008360Biological processregulation of cell shape
GO_0048010Biological processvascular endothelial growth factor receptor signaling pathway
GO_0038096Biological processFc-gamma receptor signaling pathway involved in phagocytosis
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0006468Biological processprotein phosphorylation
GO_0010632Biological processregulation of epithelial cell migration
GO_0046777Biological processprotein autophosphorylation
GO_0030155Biological processregulation of cell adhesion
GO_0007179Biological processtransforming growth factor beta receptor signaling pathway
GO_0016477Biological processcell migration
GO_0042127Biological processregulation of cell population proliferation
GO_0010634Biological processpositive regulation of epithelial cell migration
GO_0007411Biological processaxon guidance
GO_0005856Cellular componentcytoskeleton
GO_0005886Cellular componentplasma membrane
GO_0043197Cellular componentdendritic spine
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005813Cellular componentcentrosome
GO_0005925Cellular componentfocal adhesion
GO_0001725Cellular componentstress fiber
GO_0005829Cellular componentcytosol
GO_0005938Cellular componentcell cortex
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0036064Cellular componentciliary basal body
GO_0005634Cellular componentnucleus
GO_0004715Molecular functionnon-membrane spanning protein tyrosine kinase activity
GO_0140677Molecular functionmolecular function activator activity
GO_0008432Molecular functionJUN kinase binding
GO_0019903Molecular functionprotein phosphatase binding
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0019901Molecular functionprotein kinase binding
GO_0003779Molecular functionactin binding
GO_0005178Molecular functionintegrin binding
GO_0042169Molecular functionSH2 domain binding
GO_0004725Molecular functionprotein tyrosine phosphatase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePTK2
Protein nameProtein tyrosine kinase 2
Protein tyrosine kinase 2 (cDNA FLJ57218, highly similar to Focal adhesion kinase 1)
Focal adhesion kinase 1 (EC 2.7.10.2) (Protein-tyrosine kinase 2) (pp125FAK)
non-specific protein-tyrosine kinase (EC 2.7.10.2)
PTK2 protein
Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)
SynonymsFAK
FAK1
DescriptionFUNCTION: Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Phosphorylates NEDD9 following integrin stimulation . Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. .; FUNCTION: [Isoform 6]: Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription. .

AccessionsA0A8Q3WLM4
ENST00000522950.1
ENST00000524040.5
ENST00000430260.6
ENST00000521986.5
ENST00000521907.5
E5RH48
H0YAS0
E5RII9
ENST00000524257.5
E5RIR5
B4DWJ1
ENST00000519881.5
Q05397
ENST00000520045.5
ENST00000519465.5
E5RH01
ENST00000521395.5
ENST00000523670.5
H0YBZ1
E5RJQ2
E5RI72
ENST00000696786.1
E9PEI4
ENST00000519024.5
ENST00000521791.5
E5RJN1
E5RG80
E5RG86
ENST00000522424.5
ENST00000523388.5
E5RH08
E5RHK7
E5RJI4
ENST00000520475.5
ENST00000524202.5
E5RI03
ENST00000517887.5
ENST00000523539.5
ENST00000517712.5
H0YB16
E5RI29
ENST00000521059.5 [Q05397-1]
H0YB99
ENST00000521562.5
ENST00000524357.5
E5RHD8
ENST00000523679.1
ENST00000519419.5
I6L996
ENST00000521029.5
H0YBP1
ENST00000395218.3 [Q05397-7]
E5RGP1
ENST00000520151.5
ENST00000520828.5
E5RG54
ENST00000340930.7 [Q05397-5]
ENST00000522684.5 [Q05397-1]
ENST00000519993.5
E5RGA6
ENST00000517453.5
ENST00000521332.5
ENST00000523803.5
A0A1D5RMT1
E5RFW9
ENST00000523067.5
H0YB33
ENST00000519654.5
ENST00000523435.1
ENST00000521250.5
E5RIK4
ENST00000520892.5
E7ESA6
E5RG66
E5RJP0
ENST00000521981.5