CD81 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2001190Biological processpositive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
GO_0050862Biological processpositive regulation of T cell receptor signaling pathway
GO_0031623Biological processreceptor internalization
GO_0014905Biological processmyoblast fusion involved in skeletal muscle regeneration
GO_0001771Biological processimmunological synapse formation
GO_0072659Biological processprotein localization to plasma membrane
GO_0002863Biological processpositive regulation of inflammatory response to antigenic stimulus
GO_0034238Biological processmacrophage fusion
GO_0050861Biological processpositive regulation of B cell receptor signaling pathway
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0072675Biological processosteoclast fusion
GO_2000553Biological processpositive regulation of T-helper 2 cell cytokine production
GO_0070863Biological processpositive regulation of protein exit from endoplasmic reticulum
GO_0035783Biological processCD4-positive, alpha-beta T cell costimulation
GO_0046718Biological processsymbiont entry into host cell
GO_0071404Biological processcellular response to low-density lipoprotein particle stimulus
GO_1903911Biological processpositive regulation of receptor clustering
GO_0061462Biological processprotein localization to lysosome
GO_0030890Biological processpositive regulation of B cell proliferation
GO_2000563Biological processpositive regulation of CD4-positive, alpha-beta T cell proliferation
GO_1905676Biological processpositive regulation of adaptive immune memory response
GO_1905521Biological processregulation of macrophage migration
GO_1904352Biological processpositive regulation of protein catabolic process in the vacuole
GO_0002455Biological processhumoral immune response mediated by circulating immunoglobulin
GO_0031647Biological processregulation of protein stability
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0001772Cellular componentimmunological synapse
GO_0016323Cellular componentbasolateral plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0009925Cellular componentbasal plasma membrane
GO_0005925Cellular componentfocal adhesion
GO_0097197Cellular componenttetraspanin-enriched microdomain
GO_0031982Cellular componentvesicle
GO_1990459Molecular functiontransferrin receptor binding
GO_0015485Molecular functioncholesterol binding
GO_0042289Molecular functionMHC class II protein binding
GO_0001618Molecular functionvirus receptor activity
GO_0005178Molecular functionintegrin binding
GO_0023026Molecular functionMHC class II protein complex binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCD81
Protein nameCD81 molecule
Tetraspanin
CD81 antigen (26 kDa cell surface protein TAPA-1) (Target of the antiproliferative antibody 1) (Tetraspanin-28) (Tspan-28) (CD antigen CD81)
SynonymsTSPAN28
TAPA1
DescriptionFUNCTION: Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells . Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production . In T cells, facilitates the localization of CD247/CD3 zeta at antigen-induced synapses with B cells, providing for costimulation and polarization toward T helper type 2 phenotype . Present in MHC class II compartments, may also play a role in antigen presentation . Can act both as positive and negative regulator of homotypic or heterotypic cell-cell fusion processes. Positively regulates sperm-egg fusion and may be involved in acrosome reaction (By similarity). In myoblasts, associates with CD9 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD9 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles . Also prevents the fusion of mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity). May regulate the compartmentalization of enzymatic activities. In T cells, defines the subcellular localization of dNTPase SAMHD1 and permits its degradation by the proteasome, thereby controlling intracellular dNTP levels . Also involved in cell adhesion and motility. Positively regulates integrin-mediated adhesion of macrophages, particularly relevant for the inflammatory response in the lung (By similarity). .; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes. Association with CLDN1 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell. .; FUNCTION: (Microbial infection) Involved in SAMHD1-dependent restriction of HIV-1 replication. May support early replication of both R5- and X4-tropic HIV-1 viruses in T cells, likely via proteasome-dependent degradation of SAMHD1. .; FUNCTION: (Microbial infection) Specifically required for Plasmodium falciparum infectivity of hepatocytes, controlling sporozoite entry into hepatocytes via the parasitophorous vacuole and subsequent parasite differentiation to exoerythrocytic forms. .

AccessionsENST00000475945.7
ENST00000527343.5
ENST00000493525.6
ENST00000530648.5
ENST00000481687.1
ENST00000464784.6
E9PJK1
H0YDL9
H0YEE2
P60033
ENST00000381036.7
ENST00000533417.6
ENST00000492627.5
A6NMH8
ENST00000263645.10
ENST00000526072.5
E9PQV4
E9PPF5
ENST00000492252.5
E9PIF1
E9PRJ8
H0YDJ9