TRIM15 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TRIM15 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRIM15 at tissue level.

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0045087Biological processinnate immune response
GO_0032481Biological processpositive regulation of type I interferon production
GO_1901223Biological processnegative regulation of non-canonical NF-kappaB signal transduction
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_1900246Biological processpositive regulation of RIG-I signaling pathway
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0007500Biological processmesodermal cell fate determination
GO_1901253Biological processnegative regulation of intracellular transport of viral material
GO_0044790Biological processsuppression of viral release by host
GO_0005925Cellular componentfocal adhesion
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0008270Molecular functionzinc ion binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0140313Molecular functionmolecular sequestering activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTRIM15
Protein nameTripartite motif containing 15 (Tripartite motif-containing protein 15)
TRIM15 (Tripartite motif-containing protein 15)
Tripartite motif-containing protein 15
TRIM15 (Tripartite motif-containing 15)
E3 ubiquitin-protein ligase TRIM15 (EC 2.3.2.27) (RING finger protein 93) (Zinc finger protein 178) (Zinc finger protein B7)
SynonymsRNF93
ZNF178
ZNFB7
hCG_23773
DescriptionFUNCTION: E3 ubiquitin ligase that plays a role in several processes including innate antiviral immnity, cell migration and chemotaxis . Acts as a 'Lys-63'-specific ubiquitin ligase for MAPK1/ERK2 and MAPK3/ERK1, promoting their activation by facilitating their interaction with MAP2K1 and MAP2K2 . Plays also a role in cell migration and chemotaxis by acting as a stable focal adhesion component upon recruitment by multi-adapter protein paxillin/PXN . Functions in the RIGI-mediated interferon induction pathway upstream or at the level of MAVS . Inhibits NF-kappa-B activation by turnover of 'Lys-63'-linked ubiquitination of MAP3K7/TAK1. Mechanistically, prevents TRIM8 cytoplasmic translocation and thus inhibits TRIM8-mediated 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 in the cytoplasm . Plays also an important regulatory effect on the activation of hepatic stellate cells (HSCs). .

AccessionsENST00000427091.6 [Q9C019-1]
ENST00000550969.2
H0Y5R0
ENST00000552836.2 [Q9C019-2]
ENST00000619857.4
A0A087X199
ENST00000431059.6 [Q9C019-1]
ENST00000423220.5
ENST00000425255.5
ENST00000552062.2
ENST00000421984.6 [Q9C019-1]
Q5SRL0
ENST00000424597.5
A0A0G2JL27
ENST00000444157.5
ENST00000548732.2
ENST00000429524.6
ENST00000430090.6
ENST00000552676.2 [Q9C019-2]
ENST00000427952.5
A0A0G2JJP1
ENST00000414873.6 [Q9C019-1]
ENST00000548653.2
ENST00000550400.2 [Q9C019-2]
ENST00000546888.2
ENST00000550694.2
ENST00000550702.2
Q9C019
ENST00000376694.9 [Q9C019-1]
ENST00000426765.5
ENST00000433744.1
ENST00000440260.5
ENST00000259930.10 [Q9C019-1]