LIMA1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031529Biological processruffle organization
GO_0030299Biological processintestinal cholesterol absorption
GO_0008203Biological processcholesterol metabolic process
GO_0051017Biological processactin filament bundle assembly
GO_0016477Biological processcell migration
GO_0030835Biological processnegative regulation of actin filament depolymerization
GO_0042632Biological processcholesterol homeostasis
GO_0001726Cellular componentruffle
GO_0031526Cellular componentbrush border membrane
GO_0005886Cellular componentplasma membrane
GO_0005925Cellular componentfocal adhesion
GO_0001725Cellular componentstress fiber
GO_0015629Cellular componentactin cytoskeleton
GO_0005829Cellular componentcytosol
GO_0032154Cellular componentcleavage furrow
GO_0003785Molecular functionactin monomer binding
GO_0045296Molecular functioncadherin binding
GO_0051015Molecular functionactin filament binding
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLIMA1
Protein nameLIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm)
Alternative protein LIMA1
LIM domain and actin binding 1
SynonymsEPLIN
PP624
SREBP3
DescriptionFUNCTION: Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments . Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). .

AccessionsENST00000550592.1
ENST00000341247.9 [Q9UHB6-1]
ENST00000547825.5 [Q9UHB6-3]
ENST00000394943.7 [Q9UHB6-4]
ENST00000552491.5
ENST00000552783.5 [Q9UHB6-5]
ENST00000552720.5
Q9UHB6
F8VQE1
F8VRN8
F8VTU2
ENST00000551691.5
ENST00000552909.5
F8VS07
L8E8R7
ENST00000552823.5 [Q9UHB6-2]
F8VVQ7