Name | Number of supported studies | Average coverage | |
---|---|---|---|
fibroblast | 42 studies | 37% ± 14% | |
endothelial cell | 37 studies | 31% ± 11% | |
pericyte | 28 studies | 27% ± 9% | |
smooth muscle cell | 21 studies | 27% ± 7% | |
basal cell | 19 studies | 43% ± 12% | |
epithelial cell | 15 studies | 42% ± 15% | |
capillary endothelial cell | 15 studies | 24% ± 8% | |
connective tissue cell | 13 studies | 30% ± 7% | |
myofibroblast cell | 13 studies | 30% ± 11% | |
endothelial cell of artery | 13 studies | 40% ± 12% | |
oligodendrocyte precursor cell | 13 studies | 35% ± 13% | |
endothelial cell of vascular tree | 12 studies | 28% ± 13% | |
vein endothelial cell | 11 studies | 30% ± 12% | |
adipocyte | 11 studies | 66% ± 21% | |
secretory cell | 10 studies | 37% ± 15% | |
club cell | 9 studies | 29% ± 9% | |
ciliated cell | 9 studies | 28% ± 17% | |
renal alpha-intercalated cell | 8 studies | 40% ± 9% | |
retinal cone cell | 8 studies | 47% ± 15% | |
respiratory goblet cell | 7 studies | 35% ± 10% | |
GABAergic neuron | 7 studies | 28% ± 10% | |
progenitor cell | 7 studies | 29% ± 7% | |
goblet cell | 7 studies | 36% ± 20% | |
oligodendrocyte | 7 studies | 26% ± 11% | |
enterocyte | 6 studies | 34% ± 9% | |
type II pneumocyte | 6 studies | 23% ± 4% | |
ionocyte | 5 studies | 45% ± 13% | |
glutamatergic neuron | 5 studies | 32% ± 9% | |
transit amplifying cell | 5 studies | 31% ± 10% | |
retinal rod cell | 5 studies | 22% ± 4% | |
adventitial cell | 5 studies | 41% ± 6% | |
mesothelial cell | 5 studies | 36% ± 18% | |
regulatory T cell | 5 studies | 20% ± 3% | |
keratinocyte | 5 studies | 25% ± 8% | |
glomerular endothelial cell | 4 studies | 43% ± 3% | |
brush cell | 4 studies | 27% ± 11% | |
luminal hormone-sensing cell of mammary gland | 4 studies | 29% ± 8% | |
neuron | 4 studies | 23% ± 6% | |
astrocyte | 4 studies | 25% ± 9% | |
interneuron | 4 studies | 32% ± 16% | |
CD4-positive, alpha-beta memory T cell | 3 studies | 16% ± 1% | |
hillock cell | 3 studies | 31% ± 12% | |
abnormal cell | 3 studies | 26% ± 8% | |
neural crest cell | 3 studies | 21% ± 1% | |
extravillous trophoblast | 3 studies | 77% ± 3% | |
placental villous trophoblast | 3 studies | 45% ± 17% | |
glial cell | 3 studies | 27% ± 13% | |
macrophage | 3 studies | 18% ± 2% | |
muscle cell | 3 studies | 35% ± 15% | |
megakaryocyte-erythroid progenitor cell | 3 studies | 25% ± 4% | |
enteroendocrine cell | 3 studies | 28% ± 8% | |
myoepithelial cell | 3 studies | 48% ± 10% | |
mucus secreting cell | 3 studies | 31% ± 8% | |
renal principal cell | 3 studies | 25% ± 8% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
lung | 11 studies | 27% ± 15% | |
intestine | 9 studies | 25% ± 9% | |
brain | 7 studies | 28% ± 7% | |
eye | 5 studies | 24% ± 8% | |
breast | 4 studies | 24% ± 7% | |
prostate | 4 studies | 37% ± 12% | |
adipose | 4 studies | 48% ± 30% | |
kidney | 3 studies | 18% ± 4% | |
placenta | 3 studies | 38% ± 21% | |
heart | 3 studies | 18% ± 1% | |
uterus | 3 studies | 32% ± 12% | |
skin | 3 studies | 23% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 5875.46 | 1439 / 1445 | 100% | 108.15 | 183 / 183 |
lung | 100% | 10254.20 | 578 / 578 | 99% | 77.60 | 1145 / 1155 |
intestine | 100% | 9204.18 | 965 / 966 | 98% | 83.92 | 519 / 527 |
prostate | 100% | 7573.38 | 245 / 245 | 98% | 59.13 | 493 / 502 |
stomach | 99% | 5150.12 | 357 / 359 | 99% | 81.09 | 282 / 286 |
breast | 100% | 15237.56 | 459 / 459 | 97% | 82.04 | 1085 / 1118 |
bladder | 100% | 10362.38 | 21 / 21 | 95% | 78.89 | 481 / 504 |
uterus | 100% | 10497.65 | 170 / 170 | 95% | 74.08 | 434 / 459 |
thymus | 99% | 5932.26 | 647 / 653 | 95% | 45.06 | 575 / 605 |
skin | 100% | 10936.20 | 1800 / 1809 | 94% | 64.84 | 445 / 472 |
kidney | 99% | 5673.98 | 88 / 89 | 94% | 57.88 | 849 / 901 |
pancreas | 83% | 2455.99 | 273 / 328 | 98% | 99.70 | 174 / 178 |
adrenal gland | 100% | 7197.65 | 257 / 258 | 71% | 20.50 | 163 / 230 |
ovary | 100% | 6207.60 | 180 / 180 | 60% | 14.81 | 258 / 430 |
brain | 49% | 3459.70 | 1287 / 2642 | 97% | 76.98 | 686 / 705 |
adipose | 100% | 18739.61 | 1204 / 1204 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 39.87 | 1 / 1 |
blood vessel | 100% | 9312.22 | 1333 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 4742.45 | 240 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 96% | 89.05 | 43 / 45 |
heart | 75% | 2561.02 | 646 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 59% | 21.71 | 17 / 29 |
muscle | 56% | 1659.30 | 450 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 51% | 13.86 | 41 / 80 |
liver | 15% | 338.57 | 35 / 226 | 34% | 9.19 | 137 / 406 |
peripheral blood | 19% | 1034.78 | 175 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0031529 | Biological process | ruffle organization |
GO_0030299 | Biological process | intestinal cholesterol absorption |
GO_0008203 | Biological process | cholesterol metabolic process |
GO_0051017 | Biological process | actin filament bundle assembly |
GO_0016477 | Biological process | cell migration |
GO_0030835 | Biological process | negative regulation of actin filament depolymerization |
GO_0042632 | Biological process | cholesterol homeostasis |
GO_0001726 | Cellular component | ruffle |
GO_0031526 | Cellular component | brush border membrane |
GO_0005886 | Cellular component | plasma membrane |
GO_0005925 | Cellular component | focal adhesion |
GO_0001725 | Cellular component | stress fiber |
GO_0015629 | Cellular component | actin cytoskeleton |
GO_0005829 | Cellular component | cytosol |
GO_0032154 | Cellular component | cleavage furrow |
GO_0003785 | Molecular function | actin monomer binding |
GO_0045296 | Molecular function | cadherin binding |
GO_0051015 | Molecular function | actin filament binding |
GO_0046872 | Molecular function | metal ion binding |
GO_0005515 | Molecular function | protein binding |
Gene name | LIMA1 |
Protein name | LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) Alternative protein LIMA1 LIM domain and actin binding 1 |
Synonyms | EPLIN PP624 SREBP3 |
Description | FUNCTION: Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments . Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). . |
Accessions | ENST00000550592.1 ENST00000341247.9 [Q9UHB6-1] ENST00000547825.5 [Q9UHB6-3] ENST00000394943.7 [Q9UHB6-4] ENST00000552491.5 ENST00000552783.5 [Q9UHB6-5] ENST00000552720.5 Q9UHB6 F8VQE1 F8VRN8 F8VTU2 ENST00000551691.5 ENST00000552909.5 F8VS07 L8E8R7 ENST00000552823.5 [Q9UHB6-2] F8VVQ7 |