PRAG1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PRAG1 at tissue level.

III. Associated gene sets

GO_0008360Biological processregulation of cell shape
GO_0008593Biological processregulation of Notch signaling pathway
GO_0006468Biological processprotein phosphorylation
GO_0010977Biological processnegative regulation of neuron projection development
GO_0035025Biological processpositive regulation of Rho protein signal transduction
GO_0016477Biological processcell migration
GO_2000145Biological processregulation of cell motility
GO_0005829Cellular componentcytosol
GO_0005925Cellular componentfocal adhesion
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0005524Molecular functionATP binding
GO_0004672Molecular functionprotein kinase activity

IV. Literature review

[source]
Gene namePRAG1
Protein nameInactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223)
SynonymsSGK223
DescriptionFUNCTION: Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity). .

AccessionsQ86YV5
ENST00000615670.5