YWHAG | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	25 studies	27% ± 11%	Explore
macrophage	21 studies	21% ± 7%	Explore
classical monocyte	15 studies	21% ± 6%	Explore
fibroblast	13 studies	29% ± 9%	Explore
endothelial cell of lymphatic vessel	12 studies	25% ± 8%	Explore
pericyte	12 studies	24% ± 7%	Explore
smooth muscle cell	12 studies	24% ± 6%	Explore
glutamatergic neuron	11 studies	59% ± 20%	Explore
endothelial cell of vascular tree	11 studies	24% ± 8%	Explore
neuron	9 studies	46% ± 19%	Explore
GABAergic neuron	9 studies	47% ± 21%	Explore
epithelial cell	9 studies	33% ± 20%	Explore
basal cell	9 studies	27% ± 7%	Explore
adipocyte	9 studies	32% ± 8%	Explore
oligodendrocyte	9 studies	27% ± 9%	Explore
monocyte	8 studies	20% ± 6%	Explore
conventional dendritic cell	8 studies	24% ± 10%	Explore
vein endothelial cell	8 studies	23% ± 8%	Explore
microglial cell	8 studies	23% ± 6%	Explore
astrocyte	7 studies	21% ± 5%	Explore
hematopoietic precursor cell	6 studies	27% ± 11%	Explore
endothelial cell of artery	6 studies	19% ± 4%	Explore
myeloid cell	6 studies	26% ± 10%	Explore
alveolar macrophage	6 studies	22% ± 4%	Explore
non-classical monocyte	5 studies	17% ± 3%	Explore
abnormal cell	5 studies	26% ± 7%	Explore
ciliated cell	5 studies	31% ± 16%	Explore
mononuclear phagocyte	5 studies	24% ± 7%	Explore
connective tissue cell	5 studies	22% ± 7%	Explore
interneuron	5 studies	51% ± 23%	Explore
plasmacytoid dendritic cell	5 studies	22% ± 8%	Explore
retinal ganglion cell	4 studies	88% ± 15%	Explore
amacrine cell	4 studies	42% ± 13%	Explore
retina horizontal cell	4 studies	41% ± 14%	Explore
secretory cell	4 studies	24% ± 5%	Explore
dendritic cell	4 studies	34% ± 14%	Explore
hematopoietic stem cell	4 studies	23% ± 9%	Explore
mast cell	4 studies	21% ± 5%	Explore
oligodendrocyte precursor cell	4 studies	21% ± 4%	Explore
type I pneumocyte	3 studies	21% ± 5%	Explore
squamous epithelial cell	3 studies	38% ± 22%	Explore
pancreatic A cell	3 studies	38% ± 17%	Explore
retinal bipolar neuron	3 studies	32% ± 8%	Explore
GABAergic interneuron	3 studies	36% ± 9%	Explore
retinal pigment epithelial cell	3 studies	27% ± 8%	Explore
myofibroblast cell	3 studies	29% ± 10%	Explore
capillary endothelial cell	3 studies	25% ± 9%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	24% ± 6%	Explore
muscle cell	3 studies	21% ± 3%	Explore
granulocyte monocyte progenitor cell	3 studies	22% ± 6%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	38% ± 14%	Explore
enteroendocrine cell	3 studies	25% ± 10%	Explore
goblet cell	3 studies	19% ± 4%	Explore
transit amplifying cell	3 studies	24% ± 9%	Explore
granule cell	3 studies	24% ± 2%	Explore
erythroblast	3 studies	33% ± 12%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	16 studies	37% ± 19%	Explore
eye	6 studies	24% ± 8%	Explore
lung	5 studies	25% ± 7%	Explore
uterus	4 studies	24% ± 13%	Explore
pancreas	3 studies	41% ± 21%	Explore
peripheral blood	3 studies	20% ± 4%	Explore
intestine	3 studies	23% ± 4%	Explore
liver	3 studies	30% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	9313.84	1444 / 1445	100%	216.76	183 / 183
breast	100%	11605.97	458 / 459	100%	246.69	1116 / 1118
intestine	100%	8099.77	964 / 966	100%	203.02	526 / 527
brain	99%	29193.67	2627 / 2642	100%	335.31	705 / 705
bladder	100%	9719.14	21 / 21	99%	212.78	501 / 504
skin	100%	10382.21	1802 / 1809	100%	280.54	471 / 472
kidney	100%	6742.78	89 / 89	99%	185.80	894 / 901
uterus	99%	8269.04	169 / 170	100%	219.08	458 / 459
adrenal gland	100%	16067.94	258 / 258	99%	298.84	228 / 230
lung	99%	8977.11	571 / 578	100%	265.96	1155 / 1155
prostate	99%	6977.58	242 / 245	100%	198.85	501 / 502
ovary	99%	6844.65	178 / 180	100%	127.11	428 / 430
thymus	99%	6025.98	644 / 653	98%	98.50	590 / 605
stomach	84%	5476.64	303 / 359	100%	181.27	286 / 286
liver	84%	4502.33	190 / 226	98%	118.64	396 / 406
pancreas	69%	2949.70	226 / 328	99%	189.40	176 / 178
adipose	100%	15939.50	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	184.16	29 / 29
muscle	100%	28574.06	803 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	218.28	45 / 45
ureter	0%	0	0 / 0	100%	104.57	1 / 1
blood vessel	100%	10291.31	1331 / 1335	0%	0	0 / 0
spleen	100%	6324.04	240 / 241	0%	0	0 / 0
eye	0%	0	0 / 0	98%	134.52	78 / 80
heart	95%	13027.63	817 / 861	0%	0	0 / 0
peripheral blood	50%	5209.71	461 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0045664	Biological process	regulation of neuron differentiation
GO_0009966	Biological process	regulation of signal transduction
GO_0042149	Biological process	cellular response to glucose starvation
GO_0006469	Biological process	negative regulation of protein kinase activity
GO_0032869	Biological process	cellular response to insulin stimulus
GO_0007165	Biological process	signal transduction
GO_0006605	Biological process	protein targeting
GO_0048167	Biological process	regulation of synaptic plasticity
GO_0008104	Biological process	protein localization
GO_1904262	Biological process	negative regulation of TORC1 signaling
GO_0098793	Cellular component	presynapse
GO_0016020	Cellular component	membrane
GO_0070062	Cellular component	extracellular exosome
GO_0005925	Cellular component	focal adhesion
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005080	Molecular function	protein kinase C binding
GO_0005159	Molecular function	insulin-like growth factor receptor binding
GO_0019904	Molecular function	protein domain specific binding
GO_0042802	Molecular function	identical protein binding
GO_0003723	Molecular function	RNA binding
GO_0140031	Molecular function	phosphorylation-dependent protein binding
GO_0140311	Molecular function	protein sequestering activity
GO_0005515	Molecular function	protein binding
GO_0030971	Molecular function	receptor tyrosine kinase binding
GO_0008426	Molecular function	protein kinase C inhibitor activity

IV. Literature review

[source]

Gene name	YWHAG
Protein name	14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Synonyms
Description	FUNCTION: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways . Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif . Binding generally results in the modulation of the activity of the binding partner . Promotes inactivation of WDR24 component of the GATOR2 complex by binding to phosphorylated WDR24 . .
Accessions	ENST00000307630.5 P61981

YWHAG report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review