MPZL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0007267Biological processcell-cell signaling
GO_0009986Cellular componentcell surface
GO_0005886Cellular componentplasma membrane
GO_0005925Cellular componentfocal adhesion
GO_0005515Molecular functionprotein binding
GO_0005198Molecular functionstructural molecule activity

IV. Literature review

[source]
Gene nameMPZL1
Protein nameMyelin protein zero like 1
Myelin protein zero-like 1, isoform CRA_b (cDNA FLJ78597, highly similar to Homo sapiens myelin protein zero-like 1 (MPZL1), transcript variant 1, mRNA) (cDNA, FLJ96614, Homo sapiens myelin protein zero-like 1 (MPZL1), mRNA)
Myelin protein zero-like protein 1 (Protein zero-related)
SynonymsPZR
hCG_42390
UNQ849/PRO1787
DescriptionFUNCTION: Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility. .

AccessionsENST00000392121.7 [O95297-5]
A8K5D4
ENST00000367853.3
O95297
ENST00000474859.5 [O95297-3]
F8WFC4
ENST00000448405.5
Q9UEL6
ENST00000359523.7 [O95297-1]