TNS4 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TNS4 at tissue level.

III. Associated gene sets

GO_0008104Biological processprotein localization
GO_0005856Cellular componentcytoskeleton
GO_0005829Cellular componentcytosol
GO_0005925Cellular componentfocal adhesion
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding

IV. Literature review

[source]
Gene nameTNS4
Protein nameAlternative protein TNS4
TNS4 protein
Tensin 4
Tensin-4 (C-terminal tensin-like protein)
SynonymsPP14434
CTEN
DescriptionFUNCTION: Promotes EGF-induced cell migration by displacing tensin TNS3 from the cytoplasmic tail of integrin ITGB1 which results in dissociation of TNS3 from focal adhesions, disassembly of actin stress fibers and initiation of cell migration . Suppresses ligand-induced degradation of EGFR by reducing EGFR ubiquitination in the presence of EGF . Increases MET protein stability by inhibiting MET endocytosis and subsequent lysosomal degradation which leads to increased cell survival, proliferation and migration . .

AccessionsENST00000582747.1
Q8IZW8
J3QLA4
ENST00000254051.11
Q6PJP3
L0R5F6
L8E9G9