NCKAP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030838Biological processpositive regulation of actin filament polymerization
GO_0010592Biological processpositive regulation of lamellipodium assembly
GO_0030031Biological processcell projection assembly
GO_0048812Biological processneuron projection morphogenesis
GO_0016601Biological processRac protein signal transduction
GO_0007417Biological processcentral nervous system development
GO_0006915Biological processapoptotic process
GO_2000601Biological processpositive regulation of Arp2/3 complex-mediated actin nucleation
GO_0000902Biological processcell morphogenesis
GO_0030866Biological processcortical actin cytoskeleton organization
GO_0016477Biological processcell migration
GO_0001726Cellular componentruffle
GO_0031941Cellular componentfilamentous actin
GO_0070062Cellular componentextracellular exosome
GO_0005925Cellular componentfocal adhesion
GO_0031258Cellular componentlamellipodium membrane
GO_0005829Cellular componentcytosol
GO_0030027Cellular componentlamellipodium
GO_0031209Cellular componentSCAR complex
GO_0031267Molecular functionsmall GTPase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNCKAP1
Protein nameNck-associated protein 1 (NAP 1) (Membrane-associated protein HEM-2) (p125Nap1)
Nck-associated protein 1
SynonymsKIAA0587
HEM2
NAP1
DescriptionFUNCTION: Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes. .

AccessionsENST00000361354.9 [Q9Y2A7-1]
ENST00000360982.2 [Q9Y2A7-2]
ENST00000703824.1
Q9Y2A7
A0A994J4I5
A0A994J6K9
ENST00000703825.1