SDCBP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042327Biological processpositive regulation of phosphorylation
GO_0030511Biological processpositive regulation of transforming growth factor beta receptor signaling pathway
GO_0007265Biological processRas protein signal transduction
GO_0030307Biological processpositive regulation of cell growth
GO_0046330Biological processpositive regulation of JNK cascade
GO_0006612Biological processprotein targeting to membrane
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_1903543Biological processpositive regulation of exosomal secretion
GO_0030036Biological processactin cytoskeleton organization
GO_0035556Biological processintracellular signal transduction
GO_0030335Biological processpositive regulation of cell migration
GO_0006930Biological processsubstrate-dependent cell migration, cell extension
GO_0007268Biological processchemical synaptic transmission
GO_0007346Biological processregulation of mitotic cell cycle
GO_0099054Biological processpresynapse assembly
GO_0010718Biological processpositive regulation of epithelial to mesenchymal transition
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0002091Biological processnegative regulation of receptor internalization
GO_1903553Biological processpositive regulation of extracellular exosome assembly
GO_0035578Cellular componentazurophil granule lumen
GO_0005615Cellular componentextracellular space
GO_0098793Cellular componentpresynapse
GO_0005856Cellular componentcytoskeleton
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_1903561Cellular componentextracellular vesicle
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005925Cellular componentfocal adhesion
GO_0072562Cellular componentblood microparticle
GO_0005895Cellular componentinterleukin-5 receptor complex
GO_0005829Cellular componentcytosol
GO_0005912Cellular componentadherens junction
GO_0005737Cellular componentcytoplasm
GO_0031965Cellular componentnuclear membrane
GO_0042470Cellular componentmelanosome
GO_0005634Cellular componentnucleus
GO_0046875Molecular functionephrin receptor binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0005546Molecular functionphosphatidylinositol-4,5-bisphosphate binding
GO_0005109Molecular functionfrizzled binding
GO_0042802Molecular functionidentical protein binding
GO_0045545Molecular functionsyndecan binding
GO_0042043Molecular functionneurexin family protein binding
GO_0019838Molecular functiongrowth factor binding
GO_0050839Molecular functioncell adhesion molecule binding
GO_0035255Molecular functionionotropic glutamate receptor binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0005137Molecular functioninterleukin-5 receptor binding
GO_0140311Molecular functionprotein sequestering activity
GO_0008093Molecular functioncytoskeletal anchor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSDCBP
Protein nameSyndecan binding protein
Syndecan binding protein (cDNA FLJ55055, moderately similar to Syntenin-1)
Syntenin-1 (Melanoma differentiation-associated protein 9) (MDA-9) (Pro-TGF-alpha cytoplasmic domain-interacting protein 18) (TACIP18) (Scaffold protein Pbp1) (Syndecan-binding protein 1)
SynonymshCG_1787561
SYCL
MDA9
DescriptionFUNCTION: Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis . Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 . In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis . Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types . In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) . May also play a role in vesicular trafficking . Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway . .

AccessionsENST00000447182.6 [O00560-2]
ENST00000447267.4
ENST00000413219.6 [O00560-1]
O00560
ENST00000520168.5
E9PBU7
ENST00000630925.1
ENST00000424270.6 [O00560-3]
B4DHN5
ENST00000523483.5
ENST00000260130.9 [O00560-1]
G5EA09