Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| lung | 18 studies | 35% ± 15% | |
| brain | 17 studies | 35% ± 18% | |
| kidney | 9 studies | 24% ± 8% | |
| intestine | 8 studies | 22% ± 8% | |
| eye | 6 studies | 28% ± 22% | |
| heart | 5 studies | 37% ± 8% | |
| liver | 4 studies | 37% ± 16% | |
| adipose | 4 studies | 31% ± 9% | |
| pancreas | 3 studies | 42% ± 20% | |
| peripheral blood | 3 studies | 21% ± 3% | |
| placenta | 3 studies | 35% ± 16% | |
| uterus | 3 studies | 35% ± 19% | |
| breast | 3 studies | 26% ± 3% | |
| esophagus | 3 studies | 38% ± 18% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 26824.71 | 1445 / 1445 | 100% | 158.66 | 183 / 183 |
| lung | 100% | 26620.41 | 578 / 578 | 100% | 158.14 | 1153 / 1155 |
| breast | 100% | 24270.62 | 459 / 459 | 100% | 204.03 | 1115 / 1118 |
| kidney | 100% | 19330.61 | 89 / 89 | 100% | 184.35 | 898 / 901 |
| prostate | 100% | 16773.95 | 245 / 245 | 100% | 146.63 | 500 / 502 |
| uterus | 100% | 19218.88 | 170 / 170 | 100% | 161.40 | 457 / 459 |
| ovary | 100% | 16950.43 | 180 / 180 | 100% | 114.90 | 428 / 430 |
| bladder | 100% | 20540.00 | 21 / 21 | 99% | 142.68 | 501 / 504 |
| skin | 100% | 22892.84 | 1809 / 1809 | 99% | 159.59 | 469 / 472 |
| stomach | 100% | 16419.33 | 359 / 359 | 99% | 148.69 | 284 / 286 |
| intestine | 100% | 21658.95 | 966 / 966 | 99% | 160.26 | 523 / 527 |
| thymus | 100% | 20661.07 | 653 / 653 | 99% | 180.05 | 598 / 605 |
| brain | 96% | 10114.09 | 2529 / 2642 | 100% | 133.24 | 704 / 705 |
| pancreas | 97% | 8256.63 | 317 / 328 | 98% | 174.37 | 175 / 178 |
| adrenal gland | 100% | 23955.95 | 258 / 258 | 92% | 89.69 | 211 / 230 |
| liver | 90% | 6866.07 | 203 / 226 | 98% | 93.59 | 399 / 406 |
| adipose | 100% | 24980.79 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 29070.44 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 100% | 12255.73 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 177.58 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 40.34 | 1 / 1 |
| muscle | 99% | 9389.44 | 798 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 99% | 122.56 | 79 / 80 |
| heart | 98% | 20392.36 | 848 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 76% | 5744.11 | 708 / 929 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 72% | 36.90 | 21 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0042475 | Biological process | odontogenesis of dentin-containing tooth |
| GO_2001045 | Biological process | negative regulation of integrin-mediated signaling pathway |
| GO_0031103 | Biological process | axon regeneration |
| GO_0007224 | Biological process | smoothened signaling pathway |
| GO_0043297 | Biological process | apical junction assembly |
| GO_0043627 | Biological process | response to estrogen |
| GO_0001541 | Biological process | ovarian follicle development |
| GO_0007163 | Biological process | establishment or maintenance of cell polarity |
| GO_0007155 | Biological process | cell adhesion |
| GO_0045880 | Biological process | positive regulation of smoothened signaling pathway |
| GO_0007229 | Biological process | integrin-mediated signaling pathway |
| GO_0097192 | Biological process | extrinsic apoptotic signaling pathway in absence of ligand |
| GO_0008584 | Biological process | male gonad development |
| GO_0007406 | Biological process | negative regulation of neuroblast proliferation |
| GO_0008104 | Biological process | protein localization |
| GO_1900181 | Biological process | negative regulation of protein localization to nucleus |
| GO_2001240 | Biological process | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| GO_2001241 | Biological process | positive regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| GO_0090136 | Biological process | epithelial cell-cell adhesion |
| GO_0016264 | Biological process | gap junction assembly |
| GO_0098609 | Biological process | cell-cell adhesion |
| GO_2000146 | Biological process | negative regulation of cell motility |
| GO_0016477 | Biological process | cell migration |
| GO_0071681 | Biological process | cellular response to indole-3-methanol |
| GO_0007405 | Biological process | neuroblast proliferation |
| GO_0001669 | Cellular component | acrosomal vesicle |
| GO_0005915 | Cellular component | zonula adherens |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016342 | Cellular component | catenin complex |
| GO_0016600 | Cellular component | flotillin complex |
| GO_0005925 | Cellular component | focal adhesion |
| GO_0005911 | Cellular component | cell-cell junction |
| GO_0015629 | Cellular component | actin cytoskeleton |
| GO_0005829 | Cellular component | cytosol |
| GO_0005912 | Cellular component | adherens junction |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0030054 | Cellular component | cell junction |
| GO_0030027 | Cellular component | lamellipodium |
| GO_0014704 | Cellular component | intercalated disc |
| GO_0005634 | Cellular component | nucleus |
| GO_0045296 | Molecular function | cadherin binding |
| GO_0051015 | Molecular function | actin filament binding |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0008013 | Molecular function | beta-catenin binding |
| GO_0005198 | Molecular function | structural molecule activity |
| GO_0017166 | Molecular function | vinculin binding |
| GO_0045295 | Molecular function | gamma-catenin binding |
| GO_0003723 | Molecular function | RNA binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | CTNNA1 |
| Protein name | Catenin alpha 1 Catenin alpha-1 (Alpha E-catenin) (Cadherin-associated protein) (Renal carcinoma antigen NY-REN-13) Catenin (Cadherin-associated protein), alpha 1, 102kDa, isoform CRA_b (Epididymis secretory sperm binding protein) Catenin (Cadherin-associated protein), alpha 1, 102kDa, isoform CRA_a (Catenin alpha 1) CTNNA1 protein |
| Synonyms | hCG_1782385 |
| Description | FUNCTION: Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation. . |
| Accessions | ENST00000517656.5 ENST00000519113.5 ENST00000517980.5 ENST00000521640.5 E5RJL0 ENST00000522013.5 E5RJC9 E5RGU3 G3XAM7 ENST00000523912.5 E5RHR7 E5RHY5 ENST00000518910.5 ENST00000519116.5 E5RJP7 Q16370 ENST00000524127.5 E5RGG4 ENST00000520865.5 A0A384MDY0 E5RFG3 E5RFM5 E5RGY6 ENST00000521724.5 E5RIB1 ENST00000523298.5 ENST00000520339.5 E5RJ41 E5RGD2 ENST00000519768.5 E5RFM3 E5RFK9 ENST00000523685.5 ENST00000519634.5 E5RJZ2 ENST00000518381.5 ENST00000302763.12 [P35221-1] ENST00000522052.5 ENST00000520520.1 ENST00000519309.5 H0YB54 ENST00000540387.5 [P35221-3] E5RIT8 ENST00000517533.5 ENST00000627109.2 ENST00000521683.5 ENST00000520522.1 ENST00000523275.5 A0A087WZL6 E5RHJ5 E5RIE0 P35221 E5RGY7 ENST00000518825.5 E5RGS1 E5RHV7 ENST00000522227.5 ENST00000520260.5 E5RJ43 H0YBB8 ENST00000521368.5 E5RG03 ENST00000520158.5 |
