PIP5K1C report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051896Biological processregulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0034333Biological processadherens junction assembly
GO_0048488Biological processsynaptic vesicle endocytosis
GO_0030593Biological processneutrophil chemotaxis
GO_0061024Biological processmembrane organization
GO_0016079Biological processsynaptic vesicle exocytosis
GO_0046854Biological processphosphatidylinositol phosphate biosynthetic process
GO_0030036Biological processactin cytoskeleton organization
GO_0006909Biological processphagocytosis
GO_0072583Biological processclathrin-dependent endocytosis
GO_0098609Biological processcell-cell adhesion
GO_0006661Biological processphosphatidylinositol biosynthetic process
GO_0032587Cellular componentruffle membrane
GO_0098793Cellular componentpresynapse
GO_0005886Cellular componentplasma membrane
GO_0005654Cellular componentnucleoplasm
GO_0005925Cellular componentfocal adhesion
GO_0005829Cellular componentcytosol
GO_0005912Cellular componentadherens junction
GO_0001891Cellular componentphagocytic cup
GO_0010008Cellular componentendosome membrane
GO_0001931Cellular componenturopod
GO_0052742Molecular functionphosphatidylinositol kinase activity
GO_0016308Molecular function1-phosphatidylinositol-4-phosphate 5-kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePIP5K1C
Protein namePhosphatidylinositol 4-phosphate 5-kinase type-1 gamma (PIP5K1gamma) (PtdIns(4)P-5-kinase 1 gamma) (EC 2.7.1.68) (Type I phosphatidylinositol 4-phosphate 5-kinase gamma)
Phosphatidylinositol-4-phosphate 5-kinase type 1 gamma
SynonymsKIAA0589
DescriptionFUNCTION: Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility . PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (Probable). PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis (By similarity). Together with PIP5K1A, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps (By similarity). Promotes particle attachment by generating the pool of PtdIns(4,5)P2 that induces controlled actin depolymerization to facilitate Fc-gamma-R clustering. Mediates RAC1-dependent reorganization of actin filaments. Required for synaptic vesicle transport (By similarity). Controls the plasma membrane pool of PtdIns(4,5)P2 implicated in synaptic vesicle endocytosis and exocytosis . Plays a role in endocytosis mediated by clathrin and AP-2 (adaptor protein complex 2) . Required for clathrin-coated pits assembly at the synapse . Participates in cell junction assembly . Modulates adherens junctions formation by facilitating CDH1/cadherin trafficking . Required for focal adhesion dynamics. Modulates the targeting of talins (TLN1 and TLN2) to the plasma membrane and their efficient assembly into focal adhesions . Regulates the interaction between talins (TLN1 and TLN2) and beta-integrins . Required for uropodium formation and retraction of the cell rear during directed migration (By similarity). Has a role in growth factor-stimulated directional cell migration and adhesion (By similarity). Required for talin assembly into nascent adhesions forming at the leading edge toward the direction of the growth factor . Negative regulator of T-cell activation and adhesion (By similarity). Negatively regulates integrin alpha-L/beta-2 (LFA-1) polarization and adhesion induced by T-cell receptor (By similarity). Together with PIP5K1A has a role during embryogenesis and together with PIP5K1B may have a role immediately after birth (By similarity). .

AccessionsENST00000679885.1
O60331
ENST00000589578.5 [O60331-3]
A0A7P0T808
A0A7P0TAE7
ENST00000335312.8 [O60331-1]
ENST00000537021.1 [O60331-2]
ENST00000539785.5 [O60331-4]
ENST00000679828.1