ACTN4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035357Biological processperoxisome proliferator activated receptor signaling pathway
GO_1901224Biological processpositive regulation of non-canonical NF-kappaB signal transduction
GO_0055001Biological processmuscle cell development
GO_0030050Biological processvesicle transport along actin filament
GO_0032417Biological processpositive regulation of sodium:proton antiporter activity
GO_0030036Biological processactin cytoskeleton organization
GO_0042981Biological processregulation of apoptotic process
GO_0030335Biological processpositive regulation of cell migration
GO_1900025Biological processnegative regulation of substrate adhesion-dependent cell spreading
GO_0015031Biological processprotein transport
GO_0048384Biological processretinoic acid receptor signaling pathway
GO_0033209Biological processtumor necrosis factor-mediated signaling pathway
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0030018Cellular componentZ disc
GO_0070062Cellular componentextracellular exosome
GO_0032991Cellular componentprotein-containing complex
GO_0030864Cellular componentcortical actin cytoskeleton
GO_0005925Cellular componentfocal adhesion
GO_0001725Cellular componentstress fiber
GO_0015629Cellular componentactin cytoskeleton
GO_0031093Cellular componentplatelet alpha granule lumen
GO_0098871Cellular componentpostsynaptic actin cytoskeleton
GO_0005737Cellular componentcytoplasm
GO_0042995Cellular componentcell projection
GO_0031143Cellular componentpseudopodium
GO_0030054Cellular componentcell junction
GO_1990904Cellular componentribonucleoprotein complex
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0016922Molecular functionnuclear receptor binding
GO_0001882Molecular functionnucleoside binding
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0051015Molecular functionactin filament binding
GO_0005178Molecular functionintegrin binding
GO_0042974Molecular functionnuclear retinoic acid receptor binding
GO_0044325Molecular functiontransmembrane transporter binding
GO_0003723Molecular functionRNA binding
GO_0031490Molecular functionchromatin DNA binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0005509Molecular functioncalcium ion binding
GO_0030374Molecular functionnuclear receptor coactivator activity
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding

IV. Literature review

[source]
Gene nameACTN4
Protein nameActinin alpha 4 isoform 2
Alpha-actinin-4 (Non-muscle alpha-actinin 4)
Actinin alpha 4 isoform 4
ACTN4 protein
SynonymshCG_1996371
DescriptionFUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation . Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA . .

AccessionsENST00000634960.2 [O43707-1]
Q96BG6
ENST00000424234.7
H7C144
ENST00000440400.3
ENST00000589528.1
ENST00000697712.1
A0A0S2Z3G1
ENST00000634692.1 [O43707-2]
ENST00000390009.7 [O43707-2]
K7EP19
O43707
A0A8V8TL71
A0A0S2Z3G9
A0A0S2Z3X3
F5GXS2
ENST00000252699.7 [O43707-1]
A0A0S2Z3C0