EHD3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_0051260Biological processprotein homooligomerization
GO_0072659Biological processprotein localization to plasma membrane
GO_0006897Biological processendocytosis
GO_0034498Biological processearly endosome to Golgi transport
GO_0032456Biological processendocytic recycling
GO_1903358Biological processregulation of Golgi organization
GO_0090160Biological processGolgi to lysosome transport
GO_0015031Biological processprotein transport
GO_1903779Biological processregulation of cardiac conduction
GO_0086036Biological processregulation of cardiac muscle cell membrane potential
GO_0055117Biological processregulation of cardiac muscle contraction
GO_0001881Biological processreceptor recycling
GO_0005886Cellular componentplasma membrane
GO_0030139Cellular componentendocytic vesicle
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005769Cellular componentearly endosome
GO_0055038Cellular componentrecycling endosome membrane
GO_0005925Cellular componentfocal adhesion
GO_0020018Cellular componentciliary pocket membrane
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0010008Cellular componentendosome membrane
GO_0005634Cellular componentnucleus
GO_0003676Molecular functionnucleic acid binding
GO_0005525Molecular functionGTP binding
GO_0005524Molecular functionATP binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEHD3
Protein nameEH domain-containing protein 3 (PAST homolog 3)
SynonymsEHD2
PAST3
DescriptionFUNCTION: ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis . In vitro causes tubulation of endocytic membranes . Binding to phosphatidic acid induces its membrane tubulation activity (By similarity). Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment (ERC), retrograde early endosome to Golgi, and endosome to plasma membrane (rapid recycling) protein transport. Involved in the regulation of Golgi maintenance and morphology . Involved in the recycling of internalized D1 dopamine receptor . Plays a role in cardiac protein trafficking probably implicating ANK2 . Involved in the ventricular membrane targeting of SLC8A1 and CACNA1C and probably the atrial membrane localization of CACNA1GG and CACNA1H implicated in the regulation of atrial myocyte excitability and cardiac conduction (By similarity). In conjunction with EHD4 may be involved in endocytic trafficking of KDR/VEGFR2 implicated in control of glomerular function (By similarity). Involved in the rapid recycling of integrin beta-3 implicated in cell adhesion maintenance . Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle, an early step in cilium biogenesis; possibly sharing redundant functions with EHD1 . .

AccessionsENST00000322054.10 [Q9NZN3-1]
Q9NZN3