EVL | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	46 studies	60% ± 19%	Explore
CD8-positive, alpha-beta T cell	41 studies	59% ± 20%	Explore
T cell	39 studies	54% ± 18%	Explore
B cell	38 studies	40% ± 14%	Explore
CD4-positive, alpha-beta T cell	34 studies	64% ± 16%	Explore
regulatory T cell	29 studies	65% ± 19%	Explore
macrophage	27 studies	31% ± 13%	Explore
mature NK T cell	23 studies	61% ± 18%	Explore
non-classical monocyte	23 studies	36% ± 16%	Explore
endothelial cell	22 studies	30% ± 16%	Explore
memory B cell	20 studies	38% ± 11%	Explore
naive B cell	20 studies	43% ± 12%	Explore
gamma-delta T cell	19 studies	64% ± 21%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	19 studies	60% ± 16%	Explore
conventional dendritic cell	17 studies	29% ± 11%	Explore
mucosal invariant T cell	17 studies	54% ± 13%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	64% ± 16%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	71% ± 14%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	15 studies	68% ± 19%	Explore
microglial cell	15 studies	45% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell	13 studies	58% ± 18%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	62% ± 20%	Explore
glutamatergic neuron	13 studies	55% ± 23%	Explore
monocyte	13 studies	30% ± 14%	Explore
fibroblast	13 studies	23% ± 5%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	63% ± 19%	Explore
GABAergic neuron	11 studies	50% ± 22%	Explore
oligodendrocyte precursor cell	11 studies	36% ± 12%	Explore
neuron	10 studies	49% ± 18%	Explore
astrocyte	10 studies	28% ± 9%	Explore
oligodendrocyte	10 studies	26% ± 10%	Explore
leukocyte	9 studies	46% ± 10%	Explore
T follicular helper cell	9 studies	64% ± 13%	Explore
dendritic cell	9 studies	32% ± 18%	Explore
alveolar macrophage	8 studies	33% ± 7%	Explore
innate lymphoid cell	8 studies	48% ± 17%	Explore
retinal cone cell	8 studies	59% ± 11%	Explore
retinal rod cell	8 studies	49% ± 16%	Explore
pericyte	8 studies	25% ± 13%	Explore
myeloid cell	8 studies	31% ± 16%	Explore
smooth muscle cell	8 studies	19% ± 3%	Explore
ciliated cell	7 studies	32% ± 18%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	60% ± 23%	Explore
interneuron	7 studies	52% ± 19%	Explore
retinal ganglion cell	7 studies	40% ± 15%	Explore
type I pneumocyte	7 studies	21% ± 5%	Explore
CD4-positive helper T cell	6 studies	50% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	58% ± 11%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	67% ± 29%	Explore
endothelial cell of artery	6 studies	23% ± 7%	Explore
amacrine cell	6 studies	35% ± 13%	Explore
epithelial cell	6 studies	38% ± 16%	Explore
precursor B cell	6 studies	47% ± 10%	Explore
immature B cell	6 studies	58% ± 14%	Explore
type II pneumocyte	6 studies	24% ± 6%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	70% ± 20%	Explore
exhausted T cell	5 studies	80% ± 8%	Explore
plasmablast	5 studies	29% ± 10%	Explore
platelet	5 studies	24% ± 4%	Explore
abnormal cell	5 studies	33% ± 15%	Explore
retinal bipolar neuron	5 studies	24% ± 5%	Explore
lymphocyte	5 studies	54% ± 14%	Explore
pro-B cell	5 studies	39% ± 11%	Explore
T-helper 17 cell	5 studies	72% ± 12%	Explore
group 3 innate lymphoid cell	5 studies	74% ± 15%	Explore
double negative thymocyte	5 studies	76% ± 10%	Explore
vein endothelial cell	5 studies	24% ± 10%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	59% ± 25%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	64% ± 13%	Explore
hematopoietic precursor cell	4 studies	39% ± 18%	Explore
classical monocyte	4 studies	22% ± 4%	Explore
granule cell	4 studies	40% ± 6%	Explore
progenitor cell	4 studies	32% ± 10%	Explore
retinal pigment epithelial cell	4 studies	22% ± 4%	Explore
adipocyte	4 studies	19% ± 2%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	27% ± 3%	Explore
endothelial cell of vascular tree	4 studies	22% ± 5%	Explore
endothelial cell of lymphatic vessel	4 studies	19% ± 3%	Explore
basal cell	4 studies	25% ± 8%	Explore
T-helper 1 cell	4 studies	79% ± 5%	Explore
deuterosomal cell	3 studies	20% ± 3%	Explore
mononuclear phagocyte	3 studies	40% ± 25%	Explore
GABAergic interneuron	3 studies	52% ± 8%	Explore
glial cell	3 studies	28% ± 8%	Explore
retina horizontal cell	3 studies	44% ± 16%	Explore
intraepithelial lymphocyte	3 studies	77% ± 3%	Explore
GABAergic amacrine cell	3 studies	39% ± 7%	Explore
OFF-bipolar cell	3 studies	25% ± 4%	Explore
ON-bipolar cell	3 studies	26% ± 3%	Explore
glycinergic amacrine cell	3 studies	32% ± 9%	Explore
rod bipolar cell	3 studies	25% ± 5%	Explore
germinal center B cell	3 studies	46% ± 9%	Explore
hepatocyte	3 studies	44% ± 15%	Explore
connective tissue cell	3 studies	22% ± 6%	Explore
myofibroblast cell	3 studies	28% ± 5%	Explore
capillary endothelial cell	3 studies	17% ± 3%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	76% ± 11%	Explore
double-positive, alpha-beta thymocyte	3 studies	74% ± 8%	Explore
erythrocyte	3 studies	33% ± 14%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	20 studies	39% ± 20%	Explore
peripheral blood	19 studies	45% ± 12%	Explore
lung	17 studies	25% ± 7%	Explore
eye	9 studies	36% ± 12%	Explore
lymph node	6 studies	39% ± 21%	Explore
liver	6 studies	36% ± 12%	Explore
bone marrow	5 studies	29% ± 13%	Explore
intestine	4 studies	34% ± 9%	Explore
adipose	4 studies	22% ± 7%	Explore
breast	3 studies	23% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	11378.17	2641 / 2642	100%	41.59	705 / 705
prostate	100%	6724.52	244 / 245	100%	26.06	501 / 502
breast	100%	5770.34	459 / 459	99%	92.15	1109 / 1118
kidney	100%	4739.46	89 / 89	96%	20.55	869 / 901
thymus	100%	5072.19	651 / 653	97%	26.00	585 / 605
lung	100%	7103.32	577 / 578	93%	19.32	1073 / 1155
uterus	100%	7367.05	170 / 170	93%	21.07	425 / 459
ovary	100%	5982.66	180 / 180	90%	13.84	389 / 430
adrenal gland	100%	3560.00	258 / 258	89%	20.93	204 / 230
skin	98%	3629.41	1768 / 1809	87%	17.37	410 / 472
pancreas	91%	2550.15	299 / 328	92%	18.96	163 / 178
bladder	100%	4501.95	21 / 21	78%	13.65	394 / 504
liver	100%	6381.59	226 / 226	72%	9.91	294 / 406
esophagus	99%	3954.68	1436 / 1445	72%	10.86	131 / 183
stomach	100%	3548.56	358 / 359	53%	7.00	153 / 286
intestine	98%	5084.49	950 / 966	40%	5.48	212 / 527
lymph node	0%	0	0 / 0	100%	62.07	29 / 29
spleen	100%	13927.10	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	20.66	45 / 45
ureter	0%	0	0 / 0	100%	7.16	1 / 1
adipose	100%	4055.23	1201 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	99%	19.34	79 / 80
blood vessel	98%	3190.96	1306 / 1335	0%	0	0 / 0
peripheral blood	94%	9178.39	876 / 929	0%	0	0 / 0
heart	92%	2907.39	793 / 861	0%	0	0 / 0
muscle	64%	1191.71	514 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0030838	Biological process	positive regulation of actin filament polymerization
GO_0051496	Biological process	positive regulation of stress fiber assembly
GO_0009887	Biological process	animal organ morphogenesis
GO_0008154	Biological process	actin polymerization or depolymerization
GO_0007166	Biological process	cell surface receptor signaling pathway
GO_0007015	Biological process	actin filament organization
GO_0010633	Biological process	negative regulation of epithelial cell migration
GO_1900028	Biological process	negative regulation of ruffle assembly
GO_0007399	Biological process	nervous system development
GO_0051289	Biological process	protein homotetramerization
GO_0016020	Cellular component	membrane
GO_0005925	Cellular component	focal adhesion
GO_0001725	Cellular component	stress fiber
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0030027	Cellular component	lamellipodium
GO_0003779	Molecular function	actin binding
GO_0005522	Molecular function	profilin binding
GO_0005515	Molecular function	protein binding
GO_0017124	Molecular function	SH3 domain binding

IV. Literature review

[source]

Gene name	EVL
Protein name	Enah/Vasp-like EVL protein Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like)
Synonyms	RNB6
Description	FUNCTION: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization. FUNCTION: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. .
Accessions	ENST00000557153.5 ENST00000392920.8 [Q9UI08-2] G3V535 G3V2K5 ENST00000557384.5 A0A2D1PGY7 ENST00000555048.5 ENST00000554695.5 Q9UI08 ENST00000555706.5 Q499Z9 H0YJN0 ENST00000544450.6 [Q9UI08-3] ENST00000554031.5 ENST00000402714.6 [Q9UI08-1] ENST00000553875.5 G3V314 ENST00000554045.5 G3V5F7 H0YJL6 A0A087WYI2 G3V3G2

EVL report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review