PABPC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000767Biological processpositive regulation of cytoplasmic translation
GO_0060213Biological processpositive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO_0048255Biological processmRNA stabilization
GO_0000184Biological processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO_0045070Biological processpositive regulation of viral genome replication
GO_0000398Biological processmRNA splicing, via spliceosome
GO_1900153Biological processpositive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO_2000623Biological processnegative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO_0031047Biological processregulatory ncRNA-mediated gene silencing
GO_0070934Biological processCRD-mediated mRNA stabilization
GO_1900152Biological processnegative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO_0016020Cellular componentmembrane
GO_0036464Cellular componentcytoplasmic ribonucleoprotein granule
GO_0070062Cellular componentextracellular exosome
GO_0106002Cellular componentmCRD-mediated mRNA stability complex
GO_0031252Cellular componentcell leading edge
GO_0005925Cellular componentfocal adhesion
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0071013Cellular componentcatalytic step 2 spliceosome
GO_1990904Cellular componentribonucleoprotein complex
GO_0030027Cellular componentlamellipodium
GO_0010494Cellular componentcytoplasmic stress granule
GO_0005634Cellular componentnucleus
GO_0008143Molecular functionpoly(A) binding
GO_0008494Molecular functiontranslation activator activity
GO_0003729Molecular functionmRNA binding
GO_0008266Molecular functionpoly(U) RNA binding
GO_0003723Molecular functionRNA binding
GO_0003730Molecular functionmRNA 3'-UTR binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePABPC1
Protein namePolyadenylate-binding protein (PABP)
Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1)
Polyadenylate-binding protein 1
Poly(A) binding protein cytoplasmic 1
SynonymsPAB1
PABP
PABPC2
hCG_15683
PABP1
DescriptionFUNCTION: Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability . Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2 . Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs . Involved in translationally coupled mRNA turnover . Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain . Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed . By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability . .; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). .

FUNCTION: Binds the poly(A) tail of mRNA. .

FUNCTION: Binds the poly(A) tail of mRNA. .

FUNCTION: Binds the poly(A) tail of mRNA. .

FUNCTION: Binds the poly(A) tail of mRNA. .

FUNCTION: Binds the poly(A) tail of mRNA. .

FUNCTION: Binds the poly(A) tail of mRNA. .

FUNCTION: Binds the poly(A) tail of mRNA. .

AccessionsENST00000519100.6
ENST00000517990.5
H0YB75
ENST00000520868.5
A0A7I2V3J9
H0YAS7
E7ERJ7
ENST00000518293.5
E5RJB9
ENST00000678954.1
A0A7I2YQ90
ENST00000677787.1
E5RFD8
E5RHG7
H0YAS6
ENST00000518196.5
H0YB86
ENST00000676662.1
E5RGH3
ENST00000522387.5
ENST00000517403.5
E5RH24
ENST00000677765.1
ENST00000522720
ENST00000520142.2 [P11940-1]
H0YC10
H0YAW6
ENST00000520142
A0A7I2V4N4
ENST00000520804.2 [P11940-1]
ENST00000521865
A0A7I2YQ88
ENST00000523636.5
ENST00000519004.5
ENST00000523555.6 [P11940-1]
ENST00000521865.6 [P11940-1]
ENST00000523555
A0A087WTT1
H0YAR2
H0YAP2
ENST00000519622.5
ENST00000522658
H0YBN4
ENST00000677140.1
E5RJM8
ENST00000522658.6 [P11940-1]
ENST00000677478.1
ENST00000318607.10 [P11940-1]
ENST00000520804
ENST00000610907.2
ENST00000519363.1
A0A7I2YQE4
ENST00000677380.1
E7EQV3
ENST00000522720.2 [P11940-1]
ENST00000679197.1
P11940
ENST00000521067.1
A0A7I2V649
E5RGC4