| Name | mCRD-mediated mRNA stability complex |
| ID | GO_0106002 |
| collection_id | Cellular component |
| Exact synonym | mCRD-poly(A)-bridging complex, major coding region determinant of instability-mediated mRNA stability complex, major coding region instability determinant-mediated mRNA stability complex, major coding region instability determinant-poly(A)-bridging complex, major coding-region determinant of instability - poly(A) tail-bridging complex |
| Description | A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the major coding region instability determinant (mCRD) by bridging the mCRD domain and the poly(A) tail of the mRNA. In human, it consists of CSDE1, HNRPD, PABPC1, PAIP1 and SYNCRIP. |
| Comment | This complex is related to GO:0070937 CRD-mediated mRNA stability complex but binds the major protein-coding-region determinant of instability (mCRD) domain rather than the CRD. Experimentally it has been shown to act on c-FOS mRNA while GO:0070937 acts on c-MYC mRNA. |
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| Genes |