HNRNPD report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010468Biological processregulation of gene expression
GO_2000767Biological processpositive regulation of cytoplasmic translation
GO_1904355Biological processpositive regulation of telomere capping
GO_0032204Biological processregulation of telomere maintenance
GO_0010629Biological processnegative regulation of gene expression
GO_0051602Biological processresponse to electrical stimulus
GO_0006396Biological processRNA processing
GO_0071392Biological processcellular response to estradiol stimulus
GO_0001889Biological processliver development
GO_0061158Biological process3'-UTR-mediated mRNA destabilization
GO_0071732Biological processcellular response to nitric oxide
GO_1904383Biological processresponse to sodium phosphate
GO_0042752Biological processregulation of circadian rhythm
GO_0006401Biological processRNA catabolic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0070934Biological processCRD-mediated mRNA stabilization
GO_0006355Biological processregulation of DNA-templated transcription
GO_0071230Biological processcellular response to amino acid stimulus
GO_0045727Biological processpositive regulation of translation
GO_0021549Biological processcerebellum development
GO_0097167Biological processcircadian regulation of translation
GO_1905663Biological processpositive regulation of telomerase RNA reverse transcriptase activity
GO_1900152Biological processnegative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO_1901355Biological processresponse to rapamycin
GO_1990828Biological processhepatocyte dedifferentiation
GO_0051592Biological processresponse to calcium ion
GO_1904586Biological processcellular response to putrescine
GO_0098978Cellular componentglutamatergic synapse
GO_0005654Cellular componentnucleoplasm
GO_0106002Cellular componentmCRD-mediated mRNA stability complex
GO_0005829Cellular componentcytosol
GO_0014069Cellular componentpostsynaptic density
GO_1990904Cellular componentribonucleoprotein complex
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003682Molecular functionchromatin binding
GO_0042162Molecular functiontelomeric DNA binding
GO_0003680Molecular functionminor groove of adenine-thymine-rich DNA binding
GO_0035925Molecular functionmRNA 3'-UTR AU-rich region binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameHNRNPD
Protein nameHeterogeneous nuclear ribonucleoprotein D
Heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) (AU-rich element RNA-binding protein 1)
SynonymsAUF1
HNRPD
DescriptionFUNCTION: Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation. .

AccessionsA0A994J440
D6RF44
ENST00000703968.1
ENST00000508119.6
ENST00000503822.2 [Q14103-4]
ENST00000703971.1 [Q14103-2]
A0A994J4B1
ENST00000703970.1
D6RAF8
Q14103
ENST00000703973.1
ENST00000503822.2
ENST00000507010.6 [Q14103-1]
ENST00000352301.8 [Q14103-2]
H0YA96
H0Y8G5
ENST00000313899.12 [Q14103-1]
ENST00000703972.1
D6RBP9
ENST00000513584.1
ENST00000353341.8 [Q14103-3]
ENST00000703969.1
ENST00000507010.6
ENST00000514671.5
ENST00000515432.1
ENST00000509263.5
ENST00000509107.1
A0A994J4R1
D6RD83
D6RBQ9
A0A994J6S0