PAIP1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	16 studies	25% ± 10%	Explore
fibroblast	14 studies	23% ± 11%	Explore
plasmacytoid dendritic cell	11 studies	28% ± 13%	Explore
pericyte	10 studies	21% ± 5%	Explore
smooth muscle cell	10 studies	22% ± 4%	Explore
epithelial cell	9 studies	34% ± 21%	Explore
connective tissue cell	8 studies	24% ± 7%	Explore
basal cell	8 studies	28% ± 18%	Explore
endothelial cell of lymphatic vessel	8 studies	23% ± 7%	Explore
myofibroblast cell	6 studies	20% ± 3%	Explore
ciliated cell	6 studies	33% ± 14%	Explore
abnormal cell	5 studies	22% ± 7%	Explore
glutamatergic neuron	5 studies	39% ± 14%	Explore
epithelial cell of proximal tubule	4 studies	17% ± 0%	Explore
mesothelial cell	4 studies	32% ± 16%	Explore
GABAergic neuron	4 studies	33% ± 9%	Explore
oligodendrocyte precursor cell	4 studies	23% ± 4%	Explore
interneuron	4 studies	34% ± 13%	Explore
neuron	4 studies	32% ± 16%	Explore
oligodendrocyte	4 studies	25% ± 9%	Explore
conventional dendritic cell	3 studies	26% ± 9%	Explore
kidney loop of Henle epithelial cell	3 studies	18% ± 2%	Explore
endothelial cell of artery	3 studies	20% ± 3%	Explore
vein endothelial cell	3 studies	19% ± 1%	Explore
club cell	3 studies	22% ± 5%	Explore
capillary endothelial cell	3 studies	20% ± 2%	Explore
astrocyte	3 studies	30% ± 11%	Explore
retinal cone cell	3 studies	30% ± 8%	Explore
retinal rod cell	3 studies	23% ± 9%	Explore
macrophage	3 studies	22% ± 5%	Explore
endothelial cell of vascular tree	3 studies	20% ± 4%	Explore
pancreatic A cell	3 studies	29% ± 11%	Explore
pancreatic ductal cell	3 studies	47% ± 14%	Explore
enteroendocrine cell	3 studies	26% ± 15%	Explore
goblet cell	3 studies	22% ± 7%	Explore
intestinal crypt stem cell	3 studies	19% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	7 studies	27% ± 14%	Explore
brain	7 studies	28% ± 12%	Explore
intestine	4 studies	22% ± 10%	Explore
peripheral blood	3 studies	21% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2745.65	1445 / 1445	100%	65.68	183 / 183
ovary	100%	2609.96	180 / 180	100%	78.28	430 / 430
breast	100%	3612.16	459 / 459	100%	77.32	1117 / 1118
lung	100%	2633.53	577 / 578	100%	75.73	1155 / 1155
prostate	100%	2642.50	245 / 245	100%	55.63	501 / 502
brain	100%	2463.63	2639 / 2642	100%	59.87	704 / 705
uterus	100%	3067.15	170 / 170	100%	59.08	457 / 459
bladder	100%	3449.00	21 / 21	99%	58.30	501 / 504
stomach	100%	2323.61	359 / 359	99%	53.55	284 / 286
intestine	100%	3034.73	966 / 966	99%	52.13	522 / 527
thymus	100%	2905.75	653 / 653	99%	51.78	599 / 605
pancreas	99%	1577.10	326 / 328	99%	45.12	176 / 178
kidney	100%	2662.25	89 / 89	98%	43.59	885 / 901
liver	100%	1715.43	225 / 226	98%	37.23	398 / 406
adrenal gland	100%	2975.75	258 / 258	97%	37.68	224 / 230
skin	100%	2497.75	1806 / 1809	95%	51.30	449 / 472
adipose	100%	3642.18	1204 / 1204	0%	0	0 / 0
blood vessel	100%	3497.04	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	26.20	29 / 29
muscle	100%	4824.97	803 / 803	0%	0	0 / 0
spleen	100%	1809.88	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	43.89	45 / 45
ureter	0%	0	0 / 0	100%	18.55	1 / 1
heart	96%	2719.47	830 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	75%	22.52	60 / 80
peripheral blood	44%	818.53	410 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_1900152	Biological process	negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO_2000767	Biological process	positive regulation of cytoplasmic translation
GO_0006446	Biological process	regulation of translational initiation
GO_0048255	Biological process	mRNA stabilization
GO_0006413	Biological process	translational initiation
GO_0044794	Biological process	positive regulation by host of viral process
GO_0070934	Biological process	CRD-mediated mRNA stabilization
GO_0019081	Biological process	viral translation
GO_0005829	Cellular component	cytosol
GO_0106002	Cellular component	mCRD-mediated mRNA stability complex
GO_0005737	Cellular component	cytoplasm
GO_0005515	Molecular function	protein binding
GO_0003723	Molecular function	RNA binding
GO_0008494	Molecular function	translation activator activity

IV. Literature review

[source]

Gene name	PAIP1
Protein name	Poly(A) binding protein interacting protein 1 Polyadenylate-binding protein-interacting protein 1 (PABP-interacting protein 1) (PAIP-1) (Poly(A)-binding protein-interacting protein 1)
Synonyms
Description	FUNCTION: Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. .; FUNCTION: (Microbial infection) Upon interaction with SARS coronavirus SARS-CoV NSP3 protein, plays an important role in viral protein synthesis. .
Accessions	H0YA44 ENST00000511321.5 ENST00000306846.8 [Q9H074-1] ENST00000508537.1 ENST00000504639.5 A0A1D5RMS4 D6RD97 ENST00000515338.1 D6REB4 ENST00000514816.5 ENST00000514514.5 Q9H074 D6R9H8 ENST00000436644.6 [Q9H074-2] D6RJF2 ENST00000504075.1 D6RJ02 ENST00000338972.8 [Q9H074-3]

PAIP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review