SYNCRIP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000767Biological processpositive regulation of cytoplasmic translation
GO_0006396Biological processRNA processing
GO_0001649Biological processosteoblast differentiation
GO_0000398Biological processmRNA splicing, via spliceosome
GO_0008380Biological processRNA splicing
GO_0070934Biological processCRD-mediated mRNA stabilization
GO_1900152Biological processnegative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO_0017148Biological processnegative regulation of translation
GO_0071346Biological processcellular response to type II interferon
GO_0097452Cellular componentGAIT complex
GO_0016020Cellular componentmembrane
GO_0005654Cellular componentnucleoplasm
GO_0106002Cellular componentmCRD-mediated mRNA stability complex
GO_0071204Cellular componenthistone pre-mRNA 3'end processing complex
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0070937Cellular componentCRD-mediated mRNA stability complex
GO_0071013Cellular componentcatalytic step 2 spliceosome
GO_1990904Cellular componentribonucleoprotein complex
GO_0005634Cellular componentnucleus
GO_0048027Molecular functionmRNA 5'-UTR binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSYNCRIP
Protein nameHeterogeneous nuclear ribonucleoprotein Q (hnRNP Q) (Glycine- and tyrosine-rich RNA-binding protein) (GRY-RBP) (NS1-associated protein 1) (Synaptotagmin-binding, cytoplasmic RNA-interacting protein)
Synaptotagmin binding cytoplasmic RNA interacting protein (Synaptotagmin binding, cytoplasmic RNA interacting protein, isoform CRA_c)
Synaptotagmin binding cytoplasmic RNA interacting protein
Heterogeneous nuclear ribonucleoprotein Q
Synaptotagmin binding cytoplasmic RNA interacting protein (Synaptotagmin binding, cytoplasmic RNA interacting protein, isoform CRA_b) (cDNA FLJ50849, highly similar to Heterogeneous nuclear ribonucleoprotein Q)
SYNCRIP protein
SynonymsNSAP1
hCG_401112
HNRPQ
DescriptionFUNCTION: Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function. .

AccessionsENST00000676637.1 [O60506-3]
ENST00000678589.1
A0A7I2V309
ENST00000683074.1
F6UXX1
A0A7I2V5Q6
B7Z645
Q05CK9
A0A7I2V2F0
ENST00000683436.1
ENST00000616122.5
A0A7I2V346
ENST00000678930.1 [O60506-2]
ENST00000677771.1
ENST00000684462.1
ENST00000678878.1
ENST00000678816.1
A0A7I2YQN2
ENST00000444272
ENST00000678355.1 [O60506-1]
ENST00000678528.1 [O60506-3]
ENST00000676542.1
A0A7I2YQV8
ENST00000678899.1
ENST00000369622.8 [O60506-1]
A0AA34QW03
ENST00000682504.1
ENST00000355238.11 [O60506-3]
ENST00000677514.1
O60506
ENST00000677481.1
ENST00000444272.2 [O60506-3]
ENST00000678618.1
ENST00000710383.1
A0A7I2V2F2
A0A7I2V4Z0
ENST00000676688.1 [O60506-1]
A0A7I2V4J0
ENST00000677059.1
ENST00000676630.1