PARVA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_0003148Biological processoutflow tract septum morphogenesis
GO_0007163Biological processestablishment or maintenance of cell polarity
GO_0034113Biological processheterotypic cell-cell adhesion
GO_0002040Biological processsprouting angiogenesis
GO_0070252Biological processactin-mediated cell contraction
GO_0030036Biological processactin cytoskeleton organization
GO_0034446Biological processsubstrate adhesion-dependent cell spreading
GO_0050821Biological processprotein stabilization
GO_0071670Biological processsmooth muscle cell chemotaxis
GO_0008360Biological processregulation of cell shape
GO_0005886Cellular componentplasma membrane
GO_0030018Cellular componentZ disc
GO_0005925Cellular componentfocal adhesion
GO_0015629Cellular componentactin cytoskeleton
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0030027Cellular componentlamellipodium
GO_0005634Cellular componentnucleus
GO_0004860Molecular functionprotein kinase inhibitor activity
GO_0045296Molecular functioncadherin binding
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding

IV. Literature review

[source]
Gene namePARVA
Protein nameParvin alpha
Alpha-parvin (Actopaxin) (CH-ILKBP) (Calponin-like integrin-linked kinase-binding protein) (Matrix-remodeling-associated protein 2)
SynonymsMXRA2
DescriptionFUNCTION: Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration. .

AccessionsQ9NVD7
ENST00000334956.15 [Q9NVD7-1]
ENST00000528916.1
E9PS97