CLASP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032886Biological processregulation of microtubule-based process
GO_0072659Biological processprotein localization to plasma membrane
GO_1903690Biological processnegative regulation of wound healing, spreading of epidermal cells
GO_0090091Biological processpositive regulation of extracellular matrix disassembly
GO_0007052Biological processmitotic spindle organization
GO_0031110Biological processregulation of microtubule polymerization or depolymerization
GO_0007163Biological processestablishment or maintenance of cell polarity
GO_0051895Biological processnegative regulation of focal adhesion assembly
GO_0010470Biological processregulation of gastrulation
GO_0051301Biological processcell division
GO_0007020Biological processmicrotubule nucleation
GO_0034453Biological processmicrotubule anchoring
GO_0040001Biological processestablishment of mitotic spindle localization
GO_0099187Biological processpresynaptic cytoskeleton organization
GO_0007026Biological processnegative regulation of microtubule depolymerization
GO_0090307Biological processmitotic spindle assembly
GO_0007030Biological processGolgi organization
GO_0006903Biological processvesicle targeting
GO_0010458Biological processexit from mitosis
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_1904261Biological processpositive regulation of basement membrane assembly involved in embryonic body morphogenesis
GO_0010717Biological processregulation of epithelial to mesenchymal transition
GO_0031023Biological processmicrotubule organizing center organization
GO_0045921Biological processpositive regulation of exocytosis
GO_0010634Biological processpositive regulation of epithelial cell migration
GO_0051497Biological processnegative regulation of stress fiber assembly
GO_0032587Cellular componentruffle membrane
GO_0098978Cellular componentglutamatergic synapse
GO_0005876Cellular componentspindle microtubule
GO_0005886Cellular componentplasma membrane
GO_0005874Cellular componentmicrotubule
GO_0072686Cellular componentmitotic spindle
GO_0016020Cellular componentmembrane
GO_0005813Cellular componentcentrosome
GO_0000776Cellular componentkinetochore
GO_0005815Cellular componentmicrotubule organizing center
GO_0045180Cellular componentbasal cortex
GO_0005794Cellular componentGolgi apparatus
GO_0031252Cellular componentcell leading edge
GO_0005925Cellular componentfocal adhesion
GO_0005802Cellular componenttrans-Golgi network
GO_0005829Cellular componentcytosol
GO_0005828Cellular componentkinetochore microtubule
GO_0005938Cellular componentcell cortex
GO_0005881Cellular componentcytoplasmic microtubule
GO_0005737Cellular componentcytoplasm
GO_0051010Molecular functionmicrotubule plus-end binding
GO_0002162Molecular functiondystroglycan binding
GO_0008017Molecular functionmicrotubule binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCLASP2
Protein nameCytoplasmic linker associated protein 2
CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2)
Cytoplasmic linker associated protein 2 (cDNA FLJ33397 fis, clone BRACE2007937, highly similar to CLIP-associating protein 2)
SynonymsKIAA0627
hCG_1997378
DescriptionFUNCTION: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules . Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 . This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle . Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. .

AccessionsENST00000487553.5
ENST00000399362.8
ENST00000496954.2
ENST00000475576.1
H7C4X8
H7C4M5
ENST00000480013.6 [O75122-1]
D6RBU8
ENST00000480385.1
ENST00000468888.6
ENST00000476251.1
ENST00000359576.9 [O75122-3]
ENST00000313350.10 [O75122-2]
C9J668
ENST00000333778.10
ENST00000635664.1
E7EW49
ENST00000485378.6
ENST00000461133.8
E7ENG2
ENST00000487200.5
ENST00000682230.1
O75122
J3KR49
H7C4I5
E3W994
A0A0U1RQI6
ENST00000650653.1
A0A804HJG7
H7C5M8
B3KR06
E7ERI8