RPL5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000059Biological processnegative regulation of ubiquitin-dependent protein catabolic process
GO_0006412Biological processtranslation
GO_0010628Biological processpositive regulation of gene expression
GO_0000027Biological processribosomal large subunit assembly
GO_2000435Biological processnegative regulation of protein neddylation
GO_0042273Biological processribosomal large subunit biogenesis
GO_0050821Biological processprotein stabilization
GO_1901796Biological processregulation of signal transduction by p53 class mediator
GO_1904667Biological processnegative regulation of ubiquitin protein ligase activity
GO_0045727Biological processpositive regulation of translation
GO_0006364Biological processrRNA processing
GO_0002181Biological processcytoplasmic translation
GO_0005730Cellular componentnucleolus
GO_0022626Cellular componentcytosolic ribosome
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0022625Cellular componentcytosolic large ribosomal subunit
GO_0005925Cellular componentfocal adhesion
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_1990904Cellular componentribonucleoprotein complex
GO_0005634Cellular componentnucleus
GO_1990948Molecular functionubiquitin ligase inhibitor activity
GO_0048027Molecular functionmRNA 5'-UTR binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0008097Molecular function5S rRNA binding
GO_0003735Molecular functionstructural constituent of ribosome
GO_0003723Molecular functionRNA binding
GO_0003730Molecular functionmRNA 3'-UTR binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRPL5
Protein nameRibosomal protein L5
Large ribosomal subunit protein uL18 (60S ribosomal protein L5)
RPL5 protein (Ribosomal protein L5, isoform CRA_a)
SynonymsMSTP030
hCG_2028912
DescriptionFUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs . It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 . .

AccessionsA0A2R8Y4A2
ENST00000370321.8
ENST00000645300.1
R4GNJ2
ENST00000470843.5
B3KTM6
A2RUM7
Q8WYP1
ENST00000645119.1
Q9BUV4
P46777
Q5T7N0
A0A2R8Y6J3
ENST00000315741.5