TLN1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	36 studies	41% ± 14%	Explore
macrophage	35 studies	37% ± 13%	Explore
pericyte	34 studies	41% ± 19%	Explore
fibroblast	30 studies	30% ± 14%	Explore
smooth muscle cell	29 studies	42% ± 17%	Explore
B cell	28 studies	27% ± 8%	Explore
endothelial cell	28 studies	32% ± 12%	Explore
CD8-positive, alpha-beta T cell	28 studies	26% ± 10%	Explore
classical monocyte	27 studies	47% ± 17%	Explore
conventional dendritic cell	26 studies	38% ± 17%	Explore
non-classical monocyte	24 studies	52% ± 16%	Explore
CD4-positive, alpha-beta T cell	21 studies	23% ± 9%	Explore
T cell	20 studies	28% ± 11%	Explore
monocyte	19 studies	38% ± 15%	Explore
regulatory T cell	19 studies	22% ± 6%	Explore
plasmacytoid dendritic cell	18 studies	37% ± 13%	Explore
memory B cell	17 studies	26% ± 8%	Explore
gamma-delta T cell	17 studies	36% ± 11%	Explore
dendritic cell	16 studies	43% ± 22%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	41% ± 14%	Explore
mature NK T cell	15 studies	34% ± 10%	Explore
naive B cell	15 studies	24% ± 8%	Explore
myeloid cell	15 studies	39% ± 21%	Explore
mast cell	14 studies	29% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	48% ± 14%	Explore
myofibroblast cell	14 studies	34% ± 10%	Explore
endothelial cell of lymphatic vessel	13 studies	32% ± 16%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	33% ± 11%	Explore
capillary endothelial cell	12 studies	24% ± 7%	Explore
platelet	11 studies	73% ± 14%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	26% ± 7%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	25% ± 7%	Explore
mucosal invariant T cell	11 studies	32% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	37% ± 13%	Explore
endothelial cell of artery	10 studies	25% ± 6%	Explore
vein endothelial cell	10 studies	24% ± 9%	Explore
neutrophil	8 studies	28% ± 8%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	22% ± 6%	Explore
connective tissue cell	8 studies	31% ± 9%	Explore
alveolar macrophage	7 studies	28% ± 11%	Explore
innate lymphoid cell	7 studies	36% ± 8%	Explore
basal cell	7 studies	27% ± 10%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	33% ± 10%	Explore
leukocyte	7 studies	34% ± 10%	Explore
microglial cell	7 studies	32% ± 12%	Explore
hematopoietic stem cell	7 studies	42% ± 22%	Explore
epithelial cell	7 studies	31% ± 16%	Explore
hematopoietic precursor cell	6 studies	37% ± 13%	Explore
megakaryocyte	6 studies	84% ± 11%	Explore
abnormal cell	6 studies	23% ± 5%	Explore
endothelial cell of vascular tree	6 studies	31% ± 18%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	31% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	26% ± 3%	Explore
plasmablast	5 studies	38% ± 16%	Explore
exhausted T cell	5 studies	35% ± 14%	Explore
mononuclear phagocyte	5 studies	38% ± 12%	Explore
lymphocyte	5 studies	34% ± 16%	Explore
secretory cell	5 studies	30% ± 15%	Explore
T follicular helper cell	5 studies	20% ± 3%	Explore
erythrocyte	5 studies	29% ± 13%	Explore
type I pneumocyte	4 studies	27% ± 6%	Explore
plasma cell	4 studies	27% ± 15%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	26% ± 5%	Explore
precursor B cell	4 studies	33% ± 14%	Explore
immature B cell	4 studies	24% ± 4%	Explore
intermediate monocyte	4 studies	54% ± 20%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	63% ± 28%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	31% ± 14%	Explore
double negative thymocyte	4 studies	33% ± 7%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	20% ± 2%	Explore
ionocyte	3 studies	24% ± 5%	Explore
glomerular endothelial cell	3 studies	27% ± 1%	Explore
pro-B cell	3 studies	29% ± 14%	Explore
tissue-resident macrophage	3 studies	37% ± 20%	Explore
inflammatory macrophage	3 studies	30% ± 16%	Explore
germinal center B cell	3 studies	23% ± 5%	Explore
CD4-positive helper T cell	3 studies	31% ± 7%	Explore
myoepithelial cell	3 studies	31% ± 10%	Explore
neuron	3 studies	22% ± 6%	Explore
muscle cell	3 studies	43% ± 13%	Explore
GABAergic neuron	3 studies	20% ± 3%	Explore
glutamatergic neuron	3 studies	27% ± 5%	Explore
granulocyte	3 studies	28% ± 15%	Explore
goblet cell	3 studies	16% ± 1%	Explore
group 3 innate lymphoid cell	3 studies	51% ± 13%	Explore
T-helper 17 cell	3 studies	24% ± 6%	Explore
oligodendrocyte	3 studies	21% ± 5%	Explore
T-helper 1 cell	3 studies	24% ± 5%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	24% ± 6%	Explore
astrocyte	3 studies	21% ± 1%	Explore
enteroendocrine cell	3 studies	19% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	18 studies	36% ± 12%	Explore
lung	11 studies	29% ± 13%	Explore
intestine	8 studies	21% ± 7%	Explore
brain	7 studies	26% ± 8%	Explore
liver	5 studies	29% ± 11%	Explore
bone marrow	4 studies	38% ± 13%	Explore
uterus	4 studies	36% ± 8%	Explore
lymph node	4 studies	21% ± 6%	Explore
kidney	3 studies	28% ± 7%	Explore
breast	3 studies	22% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	39725.85	459 / 459	100%	141.48	1117 / 1118
prostate	100%	37601.53	244 / 245	100%	138.92	502 / 502
ovary	100%	30735.59	180 / 180	100%	134.47	428 / 430
lung	100%	45316.75	577 / 578	100%	131.08	1150 / 1155
intestine	100%	64737.95	965 / 966	99%	119.77	523 / 527
adrenal gland	100%	29681.88	258 / 258	99%	132.55	228 / 230
thymus	99%	25814.57	649 / 653	100%	129.31	603 / 605
bladder	100%	69846.71	21 / 21	98%	98.74	493 / 504
uterus	99%	63388.61	169 / 170	98%	110.65	451 / 459
skin	98%	32432.62	1766 / 1809	100%	192.89	472 / 472
kidney	97%	21069.74	86 / 89	100%	158.13	898 / 901
esophagus	95%	68785.88	1371 / 1445	100%	178.94	183 / 183
stomach	88%	37958.64	317 / 359	100%	151.53	285 / 286
liver	50%	8215.54	113 / 226	94%	70.96	383 / 406
pancreas	39%	5247.58	129 / 328	99%	147.01	176 / 178
brain	17%	2101.79	439 / 2642	100%	113.34	705 / 705
adipose	100%	50036.42	1204 / 1204	0%	0	0 / 0
blood vessel	100%	128441.66	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	214.23	80 / 80
lymph node	0%	0	0 / 0	100%	185.44	29 / 29
spleen	100%	44189.45	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	113.86	45 / 45
ureter	0%	0	0 / 0	100%	35.84	1 / 1
peripheral blood	97%	41189.31	904 / 929	0%	0	0 / 0
heart	92%	26285.88	793 / 861	0%	0	0 / 0
muscle	92%	19221.62	739 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007043	Biological process	cell-cell junction assembly
GO_0070527	Biological process	platelet aggregation
GO_0007229	Biological process	integrin-mediated signaling pathway
GO_0051893	Biological process	regulation of focal adhesion assembly
GO_0007044	Biological process	cell-substrate junction assembly
GO_0033622	Biological process	integrin activation
GO_0098609	Biological process	cell-cell adhesion
GO_0030866	Biological process	cortical actin cytoskeleton organization
GO_0001726	Cellular component	ruffle
GO_0032587	Cellular component	ruffle membrane
GO_0005856	Cellular component	cytoskeleton
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0070062	Cellular component	extracellular exosome
GO_0005925	Cellular component	focal adhesion
GO_0009986	Cellular component	cell surface
GO_0005829	Cellular component	cytosol
GO_0005912	Cellular component	adherens junction
GO_0030274	Molecular function	LIM domain binding
GO_0045296	Molecular function	cadherin binding
GO_0005200	Molecular function	structural constituent of cytoskeleton
GO_0051015	Molecular function	actin filament binding
GO_0001786	Molecular function	phosphatidylserine binding
GO_0035091	Molecular function	phosphatidylinositol binding
GO_0005178	Molecular function	integrin binding
GO_0017166	Molecular function	vinculin binding
GO_0005515	Molecular function	protein binding

Gene name	TLN1
Protein name	Talin-1
Synonyms	KIAA1027 TLN
Description	FUNCTION: High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity). Involved in connections of major cytoskeletal structures to the plasma membrane (By similarity). .
Accessions	ENST00000706939.1 [Q9Y490-2] Q9Y490 ENST00000314888.10 [Q9Y490-1]

TLN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review