RHOU report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006897Biological processendocytosis
GO_0051056Biological processregulation of small GTPase mediated signal transduction
GO_0007163Biological processestablishment or maintenance of cell polarity
GO_0007010Biological processcytoskeleton organization
GO_0016601Biological processRac protein signal transduction
GO_0007015Biological processactin filament organization
GO_0032488Biological processCdc42 protein signal transduction
GO_0008360Biological processregulation of cell shape
GO_1903955Biological processpositive regulation of protein targeting to mitochondrion
GO_0000082Biological processG1/S transition of mitotic cell cycle
GO_0005886Cellular componentplasma membrane
GO_0002102Cellular componentpodosome
GO_0005925Cellular componentfocal adhesion
GO_0000139Cellular componentGolgi membrane
GO_0005829Cellular componentcytosol
GO_0042995Cellular componentcell projection
GO_0010008Cellular componentendosome membrane
GO_0005085Molecular functionguanyl-nucleotide exchange factor activity
GO_0019901Molecular functionprotein kinase binding
GO_0005525Molecular functionGTP binding
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameRHOU
Protein nameRho-related GTP-binding protein RhoU (CDC42-like GTPase 1) (GTP-binding protein-like 1) (Rho GTPase-like protein ARHU) (Ryu GTPase) (Wnt-1 responsive Cdc42 homolog 1) (WRCH-1)
SynonymsG28K
ARHU
WRCH1
CDC42L1
SB128
DescriptionFUNCTION: Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. .

AccessionsENST00000366691.4 [Q7L0Q8-1]
ENST00000646945.2 [Q7L0Q8-1]
Q7L0Q8