NRP1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	47 studies	41% ± 17%	Explore
macrophage	30 studies	40% ± 20%	Explore
fibroblast	27 studies	36% ± 15%	Explore
capillary endothelial cell	16 studies	35% ± 15%	Explore
pericyte	16 studies	41% ± 21%	Explore
vein endothelial cell	14 studies	41% ± 18%	Explore
astrocyte	13 studies	36% ± 14%	Explore
endothelial cell of vascular tree	13 studies	31% ± 14%	Explore
smooth muscle cell	12 studies	31% ± 13%	Explore
myeloid cell	11 studies	42% ± 21%	Explore
plasmacytoid dendritic cell	10 studies	23% ± 5%	Explore
adipocyte	10 studies	50% ± 15%	Explore
connective tissue cell	9 studies	24% ± 7%	Explore
glutamatergic neuron	9 studies	34% ± 13%	Explore
endothelial cell of artery	8 studies	30% ± 15%	Explore
neuron	8 studies	33% ± 17%	Explore
microglial cell	7 studies	24% ± 5%	Explore
myofibroblast cell	6 studies	30% ± 10%	Explore
monocyte	6 studies	33% ± 14%	Explore
cardiac muscle cell	5 studies	52% ± 11%	Explore
endothelial cell of sinusoid	4 studies	51% ± 28%	Explore
glomerular endothelial cell	4 studies	53% ± 5%	Explore
abnormal cell	4 studies	38% ± 15%	Explore
glial cell	4 studies	21% ± 4%	Explore
amacrine cell	4 studies	28% ± 10%	Explore
dendritic cell	4 studies	22% ± 5%	Explore
mononuclear phagocyte	4 studies	36% ± 16%	Explore
GABAergic neuron	4 studies	29% ± 13%	Explore
hepatic stellate cell	3 studies	52% ± 20%	Explore
leukocyte	3 studies	18% ± 1%	Explore
epithelial cell	3 studies	27% ± 10%	Explore
mast cell	3 studies	24% ± 8%	Explore
tissue-resident macrophage	3 studies	44% ± 15%	Explore
GABAergic amacrine cell	3 studies	50% ± 14%	Explore
cholangiocyte	3 studies	57% ± 15%	Explore
hepatocyte	3 studies	45% ± 33%	Explore
adventitial cell	3 studies	33% ± 5%	Explore
alveolar macrophage	3 studies	39% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	9 studies	25% ± 12%	Explore
lung	7 studies	20% ± 5%	Explore
heart	6 studies	36% ± 13%	Explore
kidney	4 studies	22% ± 5%	Explore
liver	3 studies	38% ± 18%	Explore
eye	3 studies	20% ± 4%	Explore
adipose	3 studies	52% ± 25%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	14249.84	459 / 459	97%	30.62	1085 / 1118
kidney	100%	9384.43	89 / 89	97%	94.67	872 / 901
thymus	100%	11929.86	652 / 653	95%	34.38	576 / 605
lung	100%	10620.91	577 / 578	94%	33.61	1087 / 1155
adrenal gland	97%	4888.47	251 / 258	93%	32.07	213 / 230
prostate	96%	4087.40	235 / 245	92%	27.24	464 / 502
pancreas	88%	2766.43	290 / 328	96%	33.13	171 / 178
uterus	99%	7651.95	168 / 170	73%	16.01	335 / 459
ovary	100%	6810.24	180 / 180	69%	11.15	298 / 430
esophagus	78%	3732.36	1120 / 1445	86%	20.86	158 / 183
bladder	95%	4424.48	20 / 21	67%	15.95	339 / 504
liver	71%	2370.77	161 / 226	84%	22.36	342 / 406
intestine	89%	4783.29	861 / 966	64%	12.58	337 / 527
skin	85%	10052.76	1530 / 1809	61%	13.74	288 / 472
stomach	58%	2395.09	210 / 359	73%	15.78	209 / 286
adipose	100%	18267.94	1204 / 1204	0%	0	0 / 0
spleen	100%	6670.73	241 / 241	0%	0	0 / 0
heart	100%	7671.77	859 / 861	0%	0	0 / 0
blood vessel	99%	6800.12	1322 / 1335	0%	0	0 / 0
brain	21%	516.35	564 / 2642	67%	13.03	472 / 705
muscle	73%	2495.66	585 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	69%	11.05	31 / 45
lymph node	0%	0	0 / 0	34%	4.83	10 / 29
eye	0%	0	0 / 0	5%	0.49	4 / 80
peripheral blood	0%	5.73	3 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0038190	Biological process	VEGF-activated neuropilin signaling pathway
GO_0038189	Biological process	neuropilin signaling pathway
GO_0097491	Biological process	sympathetic neuron projection guidance
GO_0050918	Biological process	positive chemotaxis
GO_0060627	Biological process	regulation of vesicle-mediated transport
GO_0032489	Biological process	regulation of Cdc42 protein signal transduction
GO_0060385	Biological process	axonogenesis involved in innervation
GO_0061551	Biological process	trigeminal ganglion development
GO_0001764	Biological process	neuron migration
GO_0060978	Biological process	angiogenesis involved in coronary vascular morphogenesis
GO_0007267	Biological process	cell-cell signaling
GO_0035767	Biological process	endothelial cell chemotaxis
GO_0030947	Biological process	regulation of vascular endothelial growth factor receptor signaling pathway
GO_0061441	Biological process	renal artery morphogenesis
GO_0021637	Biological process	trigeminal nerve structural organization
GO_0021785	Biological process	branchiomotor neuron axon guidance
GO_0060982	Biological process	coronary artery morphogenesis
GO_1900026	Biological process	positive regulation of substrate adhesion-dependent cell spreading
GO_0097374	Biological process	sensory neuron axon guidance
GO_0070374	Biological process	positive regulation of ERK1 and ERK2 cascade
GO_0035924	Biological process	cellular response to vascular endothelial growth factor stimulus
GO_0048842	Biological process	positive regulation of axon extension involved in axon guidance
GO_0001525	Biological process	angiogenesis
GO_0001755	Biological process	neural crest cell migration
GO_0045766	Biological process	positive regulation of angiogenesis
GO_0007165	Biological process	signal transduction
GO_0150020	Biological process	basal dendrite arborization
GO_1905040	Biological process	otic placode development
GO_0060666	Biological process	dichotomous subdivision of terminal units involved in salivary gland branching
GO_0021828	Biological process	gonadotrophin-releasing hormone neuronal migration to the hypothalamus
GO_0014911	Biological process	positive regulation of smooth muscle cell migration
GO_0021649	Biological process	vestibulocochlear nerve structural organization
GO_0090050	Biological process	positive regulation of cell migration involved in sprouting angiogenesis
GO_0051491	Biological process	positive regulation of filopodium assembly
GO_0007229	Biological process	integrin-mediated signaling pathway
GO_0048012	Biological process	hepatocyte growth factor receptor signaling pathway
GO_0097490	Biological process	sympathetic neuron projection extension
GO_0048843	Biological process	negative regulation of axon extension involved in axon guidance
GO_1901166	Biological process	neural crest cell migration involved in autonomic nervous system development
GO_0150018	Biological process	basal dendrite development
GO_0099173	Biological process	postsynapse organization
GO_1904835	Biological process	dorsal root ganglion morphogenesis
GO_0003148	Biological process	outflow tract septum morphogenesis
GO_0051496	Biological process	positive regulation of stress fiber assembly
GO_0061299	Biological process	retina vasculature morphogenesis in camera-type eye
GO_1902946	Biological process	protein localization to early endosome
GO_0009887	Biological process	animal organ morphogenesis
GO_0097102	Biological process	endothelial tip cell fate specification
GO_0001570	Biological process	vasculogenesis
GO_0021612	Biological process	facial nerve structural organization
GO_0036486	Biological process	ventral trunk neural crest cell migration
GO_0002040	Biological process	sprouting angiogenesis
GO_0061549	Biological process	sympathetic ganglion development
GO_0001569	Biological process	branching involved in blood vessel morphogenesis
GO_0046718	Biological process	symbiont entry into host cell
GO_0006930	Biological process	substrate-dependent cell migration, cell extension
GO_0051894	Biological process	positive regulation of focal adhesion assembly
GO_0048010	Biological process	vascular endothelial growth factor receptor signaling pathway
GO_0031290	Biological process	retinal ganglion cell axon guidance
GO_0043524	Biological process	negative regulation of neuron apoptotic process
GO_0009611	Biological process	response to wounding
GO_0048844	Biological process	artery morphogenesis
GO_0035729	Biological process	cellular response to hepatocyte growth factor stimulus
GO_0002042	Biological process	cell migration involved in sprouting angiogenesis
GO_0010595	Biological process	positive regulation of endothelial cell migration
GO_0048846	Biological process	axon extension involved in axon guidance
GO_0097475	Biological process	motor neuron migration
GO_0007413	Biological process	axonal fasciculation
GO_0048008	Biological process	platelet-derived growth factor receptor signaling pathway
GO_0071679	Biological process	commissural neuron axon guidance
GO_0050731	Biological process	positive regulation of peptidyl-tyrosine phosphorylation
GO_0001938	Biological process	positive regulation of endothelial cell proliferation
GO_2001237	Biological process	negative regulation of extrinsic apoptotic signaling pathway
GO_0008045	Biological process	motor neuron axon guidance
GO_0071526	Biological process	semaphorin-plexin signaling pathway
GO_1903375	Biological process	facioacoustic ganglion development
GO_0007411	Biological process	axon guidance
GO_0098978	Cellular component	glutamatergic synapse
GO_0031966	Cellular component	mitochondrial membrane
GO_0043005	Cellular component	neuron projection
GO_0045211	Cellular component	postsynaptic membrane
GO_0005615	Cellular component	extracellular space
GO_0002116	Cellular component	semaphorin receptor complex
GO_0043235	Cellular component	receptor complex
GO_0005886	Cellular component	plasma membrane
GO_0031410	Cellular component	cytoplasmic vesicle
GO_0005769	Cellular component	early endosome
GO_0097443	Cellular component	sorting endosome
GO_0030424	Cellular component	axon
GO_0005883	Cellular component	neurofilament
GO_0005925	Cellular component	focal adhesion
GO_0005829	Cellular component	cytosol
GO_0017154	Molecular function	semaphorin receptor activity
GO_0005021	Molecular function	vascular endothelial growth factor receptor activity
GO_0019955	Molecular function	cytokine binding
GO_0015026	Molecular function	coreceptor activity
GO_0038085	Molecular function	vascular endothelial growth factor binding
GO_0046872	Molecular function	metal ion binding
GO_0008201	Molecular function	heparin binding
GO_0005096	Molecular function	GTPase activator activity
GO_0005515	Molecular function	protein binding
GO_0019901	Molecular function	protein kinase binding
GO_0019838	Molecular function	growth factor binding

IV. Literature review

[source]

Gene name	NRP1
Protein name	Neuropilin 1 Neuropilin-1 Neuropilin-1 (Vascular endothelial cell growth factor 165 receptor) (CD antigen CD304) Neuropilin
Synonyms	NRP VEGF165R hCG_19074 DKFZp686M1967
Description	FUNCTION: Cell-surface receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins . Recognizes a C-end rule (CendR) motif R/KXXR/K on its ligands which causes cellular internalization and vascular leakage . It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB . Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). Regulates mitochondrial iron transport via interaction with ABCB8/MITOSUR . .; FUNCTION: (Microbial infection) Acts as a host factor for human coronavirus SARS-CoV-2 infection. Recognizes and binds to CendR motif RRAR on SARS-CoV-2 spike protein S1 which enhances SARS-CoV-2 infection. .; FUNCTION: [Isoform 2]: Binds VEGF-165 and may inhibit its binding to cells . May induce apoptosis by sequestering VEGF-165 . May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity. .
Accessions	Q5JWQ4 ENST00000431894.5 ENST00000418675.5 ENST00000466932.1 Q9H2E0 E7EX60 Q71SW6 Q5JWQ2 Q9H2D9 H0Y7Z2 Q9H2D8 ENST00000432372.6 H0Y4N6 V9GYL7 Q5JWQ6 Q9H2D7 ENST00000374867.7 [O14786-1] Q5T7F0 ENST00000455749.1 ENST00000374821.9 [O14786-3] E9PEP6 ENST00000374875.5 O14786 Q9H2E1 Q6X907 ENST00000413802.1 ENST00000374823.9 ENST00000265371.8 [O14786-1] ENST00000374816.7 ENST00000395995.5 H0Y4A0 ENST00000374822.8 [O14786-2] Q7Z5M2

NRP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review