Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 5594.19 | 650 / 653 | 97% | 32.13 | 589 / 605 |
| lung | 100% | 19167.50 | 578 / 578 | 97% | 36.26 | 1119 / 1155 |
| prostate | 97% | 4921.25 | 238 / 245 | 99% | 27.86 | 497 / 502 |
| kidney | 99% | 4288.36 | 88 / 89 | 92% | 35.95 | 828 / 901 |
| breast | 100% | 13186.53 | 459 / 459 | 91% | 20.75 | 1014 / 1118 |
| intestine | 94% | 3895.34 | 912 / 966 | 96% | 21.06 | 506 / 527 |
| stomach | 82% | 2280.30 | 296 / 359 | 97% | 21.08 | 278 / 286 |
| bladder | 90% | 3479.57 | 19 / 21 | 88% | 21.55 | 445 / 504 |
| skin | 72% | 2649.31 | 1296 / 1809 | 94% | 28.50 | 445 / 472 |
| uterus | 91% | 4159.81 | 154 / 170 | 68% | 14.52 | 313 / 459 |
| esophagus | 62% | 1937.88 | 902 / 1445 | 91% | 21.81 | 167 / 183 |
| pancreas | 24% | 475.87 | 78 / 328 | 97% | 24.40 | 173 / 178 |
| brain | 22% | 430.46 | 572 / 2642 | 89% | 14.38 | 624 / 705 |
| ovary | 41% | 1265.77 | 73 / 180 | 69% | 14.24 | 296 / 430 |
| liver | 35% | 1241.58 | 80 / 226 | 68% | 10.08 | 277 / 406 |
| adipose | 100% | 16501.61 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 13.24 | 1 / 1 |
| spleen | 100% | 3696.00 | 240 / 241 | 0% | 0 | 0 / 0 |
| blood vessel | 99% | 9431.41 | 1316 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 97% | 15.36 | 28 / 29 |
| heart | 92% | 3664.91 | 792 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 91% | 4489.39 | 848 / 929 | 0% | 0 | 0 / 0 |
| muscle | 88% | 2964.37 | 705 / 803 | 0% | 0 | 0 / 0 |
| adrenal gland | 38% | 968.06 | 97 / 258 | 43% | 5.39 | 98 / 230 |
| tonsil | 0% | 0 | 0 / 0 | 78% | 10.65 | 35 / 45 |
| eye | 0% | 0 | 0 / 0 | 69% | 13.95 | 55 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_1902952 | Biological process | positive regulation of dendritic spine maintenance |
| GO_2000522 | Biological process | positive regulation of immunological synapse formation |
| GO_0007169 | Biological process | cell surface receptor protein tyrosine kinase signaling pathway |
| GO_0007611 | Biological process | learning or memory |
| GO_0007165 | Biological process | signal transduction |
| GO_0061523 | Biological process | cilium disassembly |
| GO_0051301 | Biological process | cell division |
| GO_0007155 | Biological process | cell adhesion |
| GO_0007010 | Biological process | cytoskeleton organization |
| GO_0140131 | Biological process | positive regulation of lymphocyte chemotaxis |
| GO_0045672 | Biological process | positive regulation of osteoclast differentiation |
| GO_0051017 | Biological process | actin filament bundle assembly |
| GO_0097021 | Biological process | lymphocyte migration into lymphoid organs |
| GO_0007229 | Biological process | integrin-mediated signaling pathway |
| GO_0030335 | Biological process | positive regulation of cell migration |
| GO_1900026 | Biological process | positive regulation of substrate adhesion-dependent cell spreading |
| GO_0030336 | Biological process | negative regulation of cell migration |
| GO_1903829 | Biological process | positive regulation of protein localization |
| GO_0016477 | Biological process | cell migration |
| GO_0032956 | Biological process | regulation of actin cytoskeleton organization |
| GO_0061098 | Biological process | positive regulation of protein tyrosine kinase activity |
| GO_0001772 | Cellular component | immunological synapse |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0000922 | Cellular component | spindle pole |
| GO_0072686 | Cellular component | mitotic spindle |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0005925 | Cellular component | focal adhesion |
| GO_0005829 | Cellular component | cytosol |
| GO_0005938 | Cellular component | cell cortex |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0036064 | Cellular component | ciliary basal body |
| GO_0030027 | Cellular component | lamellipodium |
| GO_0005819 | Cellular component | spindle |
| GO_0016323 | Cellular component | basolateral plasma membrane |
| GO_0005634 | Cellular component | nucleus |
| GO_1990782 | Molecular function | protein tyrosine kinase binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | NEDD9 |
| Protein name | Enhancer of filamentation 1 (hEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (Cas scaffolding protein family member 2) (CASS2) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (Renal carcinoma antigen NY-REN-12) (p105) [Cleaved into: Enhancer of filamentation 1 p55] Neural precursor cell expressed, developmentally down-regulated 9 |
| Synonyms | CASL |
| Description | FUNCTION: Scaffolding protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion . As a focal adhesion protein, plays a role in embryonic fibroblast migration (By similarity). May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRKL and SHPTP2 to the tyrosine phosphorylated form . Promotes adhesion and migration of lymphocytes; as a result required for the correct migration of lymphocytes to the spleen and other secondary lymphoid organs . Plays a role in the organization of T-cell F-actin cortical cytoskeleton and the centralization of T-cell receptor microclusters at the immunological synapse (By similarity). Negatively regulates cilia outgrowth in polarized cysts (By similarity). Modulates cilia disassembly via activation of AURKA-mediated phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin . Positively regulates RANKL-induced osteoclastogenesis (By similarity). Required for the maintenance of hippocampal dendritic spines in the dentate gyrus and CA1 regions, thereby involved in spatial learning and memory (By similarity). . |
| Accessions | ENST00000448183.6 D6RGD7 ENST00000620854.4 D6RDV1 ENST00000397378.7 Q14511 D6REP7 A0A087WUD2 ENST00000513989.5 ENST00000379446.10 [Q14511-1] ENST00000379433.5 [Q14511-2] D6RBQ2 ENST00000508546.5 ENST00000504387.5 [Q14511-3] |
