AFAP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001725Cellular componentstress fiber
GO_0015629Cellular componentactin cytoskeleton
GO_0005829Cellular componentcytosol
GO_0005925Cellular componentfocal adhesion
GO_0042169Molecular functionSH2 domain binding
GO_0003779Molecular functionactin binding
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene nameAFAP1
Protein nameActin filament-associated protein 1 (110 kDa actin filament-associated protein) (AFAP-110)
Actin filament associated protein 1
SynonymsAFAP
DescriptionFUNCTION: Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells. .

AccessionsA0A087X177
ENST00000382543.4 [Q8N556-2]
ENST00000420658.6 [Q8N556-2]
ENST00000360265.9 [Q8N556-1]
Q8N556
ENST00000358461.6 [Q8N556-1]
ENST00000614385.1