PFN1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	49 studies	72% ± 24%	Explore
natural killer cell	48 studies	86% ± 20%	Explore
macrophage	45 studies	78% ± 23%	Explore
endothelial cell	43 studies	61% ± 25%	Explore
T cell	42 studies	75% ± 25%	Explore
CD8-positive, alpha-beta T cell	41 studies	83% ± 19%	Explore
fibroblast	39 studies	64% ± 21%	Explore
CD4-positive, alpha-beta T cell	35 studies	83% ± 20%	Explore
pericyte	33 studies	69% ± 23%	Explore
conventional dendritic cell	31 studies	91% ± 15%	Explore
dendritic cell	29 studies	83% ± 22%	Explore
regulatory T cell	29 studies	87% ± 18%	Explore
smooth muscle cell	28 studies	72% ± 24%	Explore
classical monocyte	28 studies	88% ± 14%	Explore
plasmacytoid dendritic cell	28 studies	89% ± 13%	Explore
monocyte	27 studies	81% ± 23%	Explore
non-classical monocyte	25 studies	91% ± 16%	Explore
endothelial cell of lymphatic vessel	24 studies	75% ± 23%	Explore
mature NK T cell	24 studies	82% ± 20%	Explore
epithelial cell	24 studies	76% ± 20%	Explore
mast cell	22 studies	63% ± 22%	Explore
plasma cell	22 studies	63% ± 24%	Explore
basal cell	21 studies	73% ± 22%	Explore
gamma-delta T cell	20 studies	86% ± 18%	Explore
memory B cell	20 studies	89% ± 10%	Explore
naive B cell	19 studies	81% ± 13%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	19 studies	80% ± 16%	Explore
connective tissue cell	18 studies	71% ± 20%	Explore
CD16-negative, CD56-bright natural killer cell, human	17 studies	86% ± 19%	Explore
capillary endothelial cell	17 studies	57% ± 24%	Explore
mucosal invariant T cell	16 studies	87% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	94% ± 7%	Explore
neutrophil	16 studies	66% ± 25%	Explore
ciliated cell	15 studies	63% ± 18%	Explore
endothelial cell of artery	15 studies	66% ± 20%	Explore
myeloid cell	15 studies	79% ± 25%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	90% ± 8%	Explore
myofibroblast cell	14 studies	77% ± 21%	Explore
innate lymphoid cell	13 studies	83% ± 14%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	83% ± 23%	Explore
vein endothelial cell	13 studies	69% ± 21%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	81% ± 20%	Explore
plasmablast	12 studies	80% ± 21%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	87% ± 12%	Explore
secretory cell	12 studies	78% ± 19%	Explore
leukocyte	12 studies	69% ± 25%	Explore
goblet cell	11 studies	72% ± 24%	Explore
endothelial cell of vascular tree	11 studies	76% ± 14%	Explore
type I pneumocyte	10 studies	66% ± 19%	Explore
platelet	10 studies	72% ± 26%	Explore
T follicular helper cell	10 studies	90% ± 11%	Explore
erythrocyte	10 studies	61% ± 26%	Explore
progenitor cell	10 studies	84% ± 22%	Explore
abnormal cell	10 studies	68% ± 24%	Explore
mesothelial cell	10 studies	73% ± 21%	Explore
type II pneumocyte	9 studies	66% ± 23%	Explore
effector CD8-positive, alpha-beta T cell	9 studies	85% ± 20%	Explore
club cell	8 studies	75% ± 21%	Explore
mononuclear phagocyte	8 studies	70% ± 28%	Explore
enterocyte	8 studies	71% ± 25%	Explore
IgG plasma cell	8 studies	46% ± 19%	Explore
hematopoietic stem cell	8 studies	88% ± 14%	Explore
alveolar macrophage	7 studies	75% ± 28%	Explore
effector CD4-positive, alpha-beta T cell	7 studies	80% ± 25%	Explore
IgA plasma cell	7 studies	44% ± 23%	Explore
brush cell	7 studies	61% ± 17%	Explore
hematopoietic precursor cell	6 studies	75% ± 21%	Explore
ionocyte	6 studies	71% ± 14%	Explore
respiratory goblet cell	6 studies	64% ± 25%	Explore
epithelial cell of proximal tubule	6 studies	68% ± 18%	Explore
kidney loop of Henle epithelial cell	6 studies	58% ± 14%	Explore
renal alpha-intercalated cell	6 studies	75% ± 10%	Explore
megakaryocyte	6 studies	87% ± 14%	Explore
transit amplifying cell	6 studies	71% ± 28%	Explore
precursor B cell	6 studies	92% ± 5%	Explore
immature B cell	6 studies	92% ± 10%	Explore
neuron	6 studies	55% ± 25%	Explore
microglial cell	6 studies	69% ± 20%	Explore
intermediate monocyte	6 studies	92% ± 12%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	89% ± 12%	Explore
CD4-positive helper T cell	5 studies	75% ± 12%	Explore
CD4-positive, alpha-beta cytotoxic T cell	5 studies	85% ± 19%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	90% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	93% ± 4%	Explore
exhausted T cell	5 studies	97% ± 3%	Explore
enteroendocrine cell	5 studies	83% ± 14%	Explore
erythroblast	5 studies	70% ± 24%	Explore
lymphocyte	5 studies	75% ± 31%	Explore
T-helper 17 cell	5 studies	93% ± 6%	Explore
group 3 innate lymphoid cell	5 studies	91% ± 3%	Explore
double negative thymocyte	5 studies	96% ± 3%	Explore
hepatocyte	5 studies	50% ± 28%	Explore
granulocyte	5 studies	81% ± 15%	Explore
duct epithelial cell	4 studies	74% ± 7%	Explore
pancreatic A cell	4 studies	80% ± 14%	Explore
type B pancreatic cell	4 studies	68% ± 18%	Explore
endothelial cell of sinusoid	4 studies	35% ± 20%	Explore
glomerular endothelial cell	4 studies	54% ± 15%	Explore
podocyte	4 studies	75% ± 14%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	80% ± 15%	Explore
oligodendrocyte	4 studies	32% ± 11%	Explore
intestinal crypt stem cell	4 studies	89% ± 7%	Explore
astrocyte	4 studies	35% ± 20%	Explore
retinal ganglion cell	4 studies	63% ± 29%	Explore
pro-B cell	4 studies	88% ± 3%	Explore
retina horizontal cell	4 studies	36% ± 18%	Explore
adventitial cell	4 studies	67% ± 11%	Explore
mucus secreting cell	4 studies	64% ± 18%	Explore
inflammatory macrophage	4 studies	77% ± 16%	Explore
muscle cell	4 studies	54% ± 19%	Explore
germinal center B cell	4 studies	96% ± 2%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	85% ± 9%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	78% ± 35%	Explore
glial cell	4 studies	57% ± 18%	Explore
melanocyte	4 studies	62% ± 26%	Explore
T-helper 1 cell	4 studies	97% ± 3%	Explore
deuterosomal cell	3 studies	63% ± 4%	Explore
precursor cell	3 studies	97% ± 1%	Explore
pancreatic D cell	3 studies	72% ± 23%	Explore
monocyte-derived dendritic cell	3 studies	88% ± 17%	Explore
neural crest cell	3 studies	90% ± 8%	Explore
renal principal cell	3 studies	70% ± 10%	Explore
thymocyte	3 studies	70% ± 24%	Explore
extravillous trophoblast	3 studies	97% ± 3%	Explore
placental villous trophoblast	3 studies	96% ± 3%	Explore
neuroendocrine cell	3 studies	80% ± 16%	Explore
amacrine cell	3 studies	45% ± 16%	Explore
serous secreting cell	3 studies	62% ± 4%	Explore
tissue-resident macrophage	3 studies	71% ± 28%	Explore
follicular B cell	3 studies	81% ± 11%	Explore
intraepithelial lymphocyte	3 studies	96% ± 3%	Explore
Mueller cell	3 studies	27% ± 7%	Explore
myoepithelial cell	3 studies	82% ± 3%	Explore
luminal cell of prostate epithelium	3 studies	65% ± 8%	Explore
IgM plasma cell	3 studies	69% ± 20%	Explore
acinar cell	3 studies	53% ± 27%	Explore
pancreatic ductal cell	3 studies	89% ± 8%	Explore
oligodendrocyte precursor cell	3 studies	51% ± 26%	Explore
keratinocyte	3 studies	82% ± 10%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	95% ± 3%	Explore
double-positive, alpha-beta thymocyte	3 studies	97% ± 1%	Explore
progenitor cell of mammary luminal epithelium	3 studies	87% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	20 studies	87% ± 11%	Explore
lung	19 studies	72% ± 18%	Explore
intestine	13 studies	67% ± 20%	Explore
liver	9 studies	50% ± 25%	Explore
kidney	9 studies	67% ± 24%	Explore
brain	7 studies	45% ± 26%	Explore
eye	7 studies	31% ± 15%	Explore
lymph node	7 studies	82% ± 13%	Explore
bone marrow	6 studies	70% ± 27%	Explore
uterus	6 studies	64% ± 29%	Explore
pancreas	5 studies	64% ± 26%	Explore
placenta	4 studies	83% ± 17%	Explore
prostate	4 studies	67% ± 21%	Explore
breast	4 studies	80% ± 10%	Explore
ovary	3 studies	38% ± 13%	Explore
heart	3 studies	38% ± 15%	Explore
adrenal gland	3 studies	71% ± 20%	Explore
esophagus	3 studies	62% ± 19%	Explore
skin	3 studies	70% ± 14%	Explore
stomach	3 studies	36% ± 16%	Explore
thymus	3 studies	75% ± 32%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	28323.13	1445 / 1445	100%	947.44	183 / 183
intestine	100%	32605.28	966 / 966	100%	1172.33	527 / 527
uterus	100%	23754.34	170 / 170	100%	1069.94	459 / 459
skin	100%	24387.35	1807 / 1809	100%	1028.06	472 / 472
thymus	100%	12469.55	651 / 653	100%	767.79	604 / 605
bladder	100%	26123.24	21 / 21	99%	1058.14	500 / 504
stomach	99%	17749.41	357 / 359	100%	1122.83	285 / 286
prostate	100%	18406.29	244 / 245	99%	596.69	499 / 502
ovary	99%	9905.47	178 / 180	100%	1216.72	430 / 430
lung	100%	24411.09	577 / 578	99%	826.49	1144 / 1155
liver	100%	15109.37	225 / 226	99%	565.83	403 / 406
breast	100%	16982.35	458 / 459	99%	800.70	1105 / 1118
kidney	100%	17963.99	89 / 89	98%	678.46	885 / 901
adrenal gland	100%	14935.17	258 / 258	97%	354.31	222 / 230
pancreas	73%	5033.34	238 / 328	99%	771.01	176 / 178
brain	66%	4149.89	1732 / 2642	99%	459.22	695 / 705
adipose	100%	19052.69	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	612.25	80 / 80
lymph node	0%	0	0 / 0	100%	2569.56	29 / 29
peripheral blood	100%	61703.66	929 / 929	0%	0	0 / 0
spleen	100%	34638.30	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	974.13	45 / 45
ureter	0%	0	0 / 0	100%	593.31	1 / 1
blood vessel	100%	29213.84	1334 / 1335	0%	0	0 / 0
heart	93%	8783.35	804 / 861	0%	0	0 / 0
muscle	85%	7698.01	683 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0030837	Biological process	negative regulation of actin filament polymerization
GO_0030838	Biological process	positive regulation of actin filament polymerization
GO_0050804	Biological process	modulation of chemical synaptic transmission
GO_0032781	Biological process	positive regulation of ATP-dependent activity
GO_0030833	Biological process	regulation of actin filament polymerization
GO_0006357	Biological process	regulation of transcription by RNA polymerase II
GO_0032233	Biological process	positive regulation of actin filament bundle assembly
GO_1900029	Biological process	positive regulation of ruffle assembly
GO_0030036	Biological process	actin cytoskeleton organization
GO_0098885	Biological process	modification of postsynaptic actin cytoskeleton
GO_0050821	Biological process	protein stabilization
GO_0060074	Biological process	synapse maturation
GO_0001843	Biological process	neural tube closure
GO_0032232	Biological process	negative regulation of actin filament bundle assembly
GO_0010634	Biological process	positive regulation of epithelial cell migration
GO_0051497	Biological process	negative regulation of stress fiber assembly
GO_0098978	Cellular component	glutamatergic synapse
GO_0005856	Cellular component	cytoskeleton
GO_0016020	Cellular component	membrane
GO_0070062	Cellular component	extracellular exosome
GO_0005925	Cellular component	focal adhesion
GO_0072562	Cellular component	blood microparticle
GO_0005829	Cellular component	cytosol
GO_0005938	Cellular component	cell cortex
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0003785	Molecular function	actin monomer binding
GO_0000774	Molecular function	adenyl-nucleotide exchange factor activity
GO_0070064	Molecular function	proline-rich region binding
GO_0045296	Molecular function	cadherin binding
GO_0005546	Molecular function	phosphatidylinositol-4,5-bisphosphate binding
GO_0031267	Molecular function	small GTPase binding
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding
GO_0003779	Molecular function	actin binding
GO_0001784	Molecular function	phosphotyrosine residue binding

Gene name	PFN1
Protein name	Profilin-1 (Epididymis tissue protein Li 184a) (Profilin I) Profilin
Synonyms	hCG_32691
Description	FUNCTION: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR. .
Accessions	ENST00000572383.1 ENST00000225655.6 I3L3D5 P07737 ENST00000574872.1 K7EJ44

PFN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review