NME2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045682Biological processregulation of epidermis development
GO_0007155Biological processcell adhesion
GO_0006228Biological processUTP biosynthetic process
GO_0050679Biological processpositive regulation of epithelial cell proliferation
GO_0007229Biological processintegrin-mediated signaling pathway
GO_0042981Biological processregulation of apoptotic process
GO_0043066Biological processnegative regulation of apoptotic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006183Biological processGTP biosynthetic process
GO_0009142Biological processnucleoside triphosphate biosynthetic process
GO_0045618Biological processpositive regulation of keratinocyte differentiation
GO_0006241Biological processCTP biosynthetic process
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0001726Cellular componentruffle
GO_0005576Cellular componentextracellular region
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0070062Cellular componentextracellular exosome
GO_0034774Cellular componentsecretory granule lumen
GO_0005925Cellular componentfocal adhesion
GO_1904813Cellular componentficolin-1-rich granule lumen
GO_0005829Cellular componentcytosol
GO_0071944Cellular componentcell periphery
GO_0005737Cellular componentcytoplasm
GO_0030027Cellular componentlamellipodium
GO_0005634Cellular componentnucleus
GO_0019003Molecular functionGDP binding
GO_0003677Molecular functionDNA binding
GO_0004550Molecular functionnucleoside diphosphate kinase activity
GO_0051880Molecular functionG-quadruplex DNA binding
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0004673Molecular functionprotein histidine kinase activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNME2
Protein nameNucleoside diphosphate kinase (EC 2.7.4.6)
Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (EC 2.7.4.6) (C-myc purine-binding transcription factor PUF) (Histidine protein kinase NDKB) (EC 2.7.13.3) (nm23-H2)
Histidine protein kinase NDKB (EC 2.7.13.3) (EC 2.7.4.6)
SynonymshCG_2001850
HEL-S-155an
NM23B
DescriptionFUNCTION: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC . Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically . Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE III(1) . Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not . Exhibits histidine protein kinase activity . .

AccessionsENST00000393183.7
ENST00000514264.6 [P22392-1]
ENST00000512737.6 [P22392-1]
ENST00000513177.5 [P22392-1]
Q6FHN3
F6XY72
ENST00000393190.4 [P22392-1]
ENST00000503064.5 [P22392-1]
P22392